Alterations in Gastric Mucosal Microbiota in Gastric Carcinogenesis: A Systematic Review and Meta-Analysis

Background: The gastric microbiota profile alters during gastric carcinogenesis. We aimed to identify the alterations in the alpha diversity and relative abundance of bacterial phyla and genera of gastric microbiota in the development of gastric cancer (GC).Methods: The systematic review was perform...

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Autores principales:	Yingyun Yang, Ruoyu Ji, Xinyu Zhao, Xinyuan Cao, Qiang Wang, Qingwei Jiang, Yizhen Zhang, Weiyang Zheng, Xi Wu, Aiming Yang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	gastric microbiota gastric cancer dysbiosis stomach microhabitat meta-analysis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8352e62551184811916dba70ad1afa11
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spelling	oai:doaj.org-article:8352e62551184811916dba70ad1afa112021-12-03T05:27:38ZAlterations in Gastric Mucosal Microbiota in Gastric Carcinogenesis: A Systematic Review and Meta-Analysis2296-858X10.3389/fmed.2021.754959https://doaj.org/article/8352e62551184811916dba70ad1afa112021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.754959/fullhttps://doaj.org/toc/2296-858XBackground: The gastric microbiota profile alters during gastric carcinogenesis. We aimed to identify the alterations in the alpha diversity and relative abundance of bacterial phyla and genera of gastric microbiota in the development of gastric cancer (GC).Methods: The systematic review was performed based on a published protocol with the registration number CRD42020206973. We searched through PubMed, EMBASE and Cochrane databases, as well as conference proceedings and references of review articles (May 2021) for observational studies reporting either the relative abundance of bacterial phyla or genera, or alpha diversity indexes in both GC and non-cancer groups. Selection of studies and data extraction were performed independently by two researchers, with disagreements resolved through discussion. Risk of bias was assessed using the self-modified Newcastle-Ottawa Scale. Results of random-effects meta-analyses were presented as mean differences (MD).Results: Our systematic review included 751 GC patients and 792 non-cancer patients from 14 case-control studies. Gastric cancer group had fewer operational taxonomic units (OTUs) (MD = −68.52, 95%CI: −126.65 to −10.39) and a lower Simpson index (MD = −0.13, 95%CI: −0.20 to −0.07) compared with non-cancer group. At the phylum level, gastric cancer group had a higher abundance of Firmicutes (MD = 7.11, 95%CI: 1.76 to 12.46). At the genus level, Streptococcus (MD = 3.03, 95%CI: 0.07 to 6.00) and Lactobacillus (MD = 5.15, 95%CI: 1.27 to 9.04) were found to be enriched in GCgroup. The relative abundance of the rest bacterial phyla or genera analyzed in our study did not significantly differ between two groups. Subgroup analyses indicated that the source of samples was the major source of interstudy heterogeneity.Conclusion: This systematic review suggested that gastric microbiota dysbiosis occurred in gastric carcinogenesis, with alpha diversity declined and microbiota composition altered.Yingyun YangRuoyu JiXinyu ZhaoXinyuan CaoQiang WangQingwei JiangYizhen ZhangWeiyang ZhengXi WuAiming YangFrontiers Media S.A.articlegastric microbiotagastric cancerdysbiosisstomach microhabitatmeta-analysisMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gastric microbiota gastric cancer dysbiosis stomach microhabitat meta-analysis Medicine (General) R5-920
spellingShingle	gastric microbiota gastric cancer dysbiosis stomach microhabitat meta-analysis Medicine (General) R5-920 Yingyun Yang Ruoyu Ji Xinyu Zhao Xinyuan Cao Qiang Wang Qingwei Jiang Yizhen Zhang Weiyang Zheng Xi Wu Aiming Yang Alterations in Gastric Mucosal Microbiota in Gastric Carcinogenesis: A Systematic Review and Meta-Analysis
description	Background: The gastric microbiota profile alters during gastric carcinogenesis. We aimed to identify the alterations in the alpha diversity and relative abundance of bacterial phyla and genera of gastric microbiota in the development of gastric cancer (GC).Methods: The systematic review was performed based on a published protocol with the registration number CRD42020206973. We searched through PubMed, EMBASE and Cochrane databases, as well as conference proceedings and references of review articles (May 2021) for observational studies reporting either the relative abundance of bacterial phyla or genera, or alpha diversity indexes in both GC and non-cancer groups. Selection of studies and data extraction were performed independently by two researchers, with disagreements resolved through discussion. Risk of bias was assessed using the self-modified Newcastle-Ottawa Scale. Results of random-effects meta-analyses were presented as mean differences (MD).Results: Our systematic review included 751 GC patients and 792 non-cancer patients from 14 case-control studies. Gastric cancer group had fewer operational taxonomic units (OTUs) (MD = −68.52, 95%CI: −126.65 to −10.39) and a lower Simpson index (MD = −0.13, 95%CI: −0.20 to −0.07) compared with non-cancer group. At the phylum level, gastric cancer group had a higher abundance of Firmicutes (MD = 7.11, 95%CI: 1.76 to 12.46). At the genus level, Streptococcus (MD = 3.03, 95%CI: 0.07 to 6.00) and Lactobacillus (MD = 5.15, 95%CI: 1.27 to 9.04) were found to be enriched in GCgroup. The relative abundance of the rest bacterial phyla or genera analyzed in our study did not significantly differ between two groups. Subgroup analyses indicated that the source of samples was the major source of interstudy heterogeneity.Conclusion: This systematic review suggested that gastric microbiota dysbiosis occurred in gastric carcinogenesis, with alpha diversity declined and microbiota composition altered.
format	article
author	Yingyun Yang Ruoyu Ji Xinyu Zhao Xinyuan Cao Qiang Wang Qingwei Jiang Yizhen Zhang Weiyang Zheng Xi Wu Aiming Yang
author_facet	Yingyun Yang Ruoyu Ji Xinyu Zhao Xinyuan Cao Qiang Wang Qingwei Jiang Yizhen Zhang Weiyang Zheng Xi Wu Aiming Yang
author_sort	Yingyun Yang
title	Alterations in Gastric Mucosal Microbiota in Gastric Carcinogenesis: A Systematic Review and Meta-Analysis
title_short	Alterations in Gastric Mucosal Microbiota in Gastric Carcinogenesis: A Systematic Review and Meta-Analysis
title_full	Alterations in Gastric Mucosal Microbiota in Gastric Carcinogenesis: A Systematic Review and Meta-Analysis
title_fullStr	Alterations in Gastric Mucosal Microbiota in Gastric Carcinogenesis: A Systematic Review and Meta-Analysis
title_full_unstemmed	Alterations in Gastric Mucosal Microbiota in Gastric Carcinogenesis: A Systematic Review and Meta-Analysis
title_sort	alterations in gastric mucosal microbiota in gastric carcinogenesis: a systematic review and meta-analysis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/8352e62551184811916dba70ad1afa11
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_version_	1718373941462958080

Alterations in Gastric Mucosal Microbiota in Gastric Carcinogenesis: A Systematic Review and Meta-Analysis

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