Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance

Exhausted T cells arise when chronic activation triggers functional defects. Here the authors show that chronic antigenic stimulation in both tumour and infection models induces the expression of EGR2, which drives and stabilises exhausted cell epigenetic and transcriptional identity.

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Autores principales:	Mayura V. Wagle, Stephin J. Vervoort, Madison J. Kelly, Willem Van Der Byl, Timothy J. Peters, Ben P. Martin, Luciano G. Martelotto, Simone Nüssing, Kelly M. Ramsbottom, James R. Torpy, Deborah Knight, Sinead Reading, Kevin Thia, Lisa A. Miosge, Debbie R. Howard, Renee Gloury, Sarah S. Gabriel, Daniel T. Utzschneider, Jane Oliaro, Jonathan D. Powell, Fabio Luciani, Joseph A. Trapani, Ricky W. Johnstone, Axel Kallies, Christopher C. Goodnow, Ian A. Parish
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/835402bfc1a5448994d0c742c77cfabd
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spelling	oai:doaj.org-article:835402bfc1a5448994d0c742c77cfabd2021-12-02T16:50:35ZAntigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance10.1038/s41467-021-23044-92041-1723https://doaj.org/article/835402bfc1a5448994d0c742c77cfabd2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23044-9https://doaj.org/toc/2041-1723Exhausted T cells arise when chronic activation triggers functional defects. Here the authors show that chronic antigenic stimulation in both tumour and infection models induces the expression of EGR2, which drives and stabilises exhausted cell epigenetic and transcriptional identity.Mayura V. WagleStephin J. VervoortMadison J. KellyWillem Van Der BylTimothy J. PetersBen P. MartinLuciano G. MartelottoSimone NüssingKelly M. RamsbottomJames R. TorpyDeborah KnightSinead ReadingKevin ThiaLisa A. MiosgeDebbie R. HowardRenee GlourySarah S. GabrielDaniel T. UtzschneiderJane OliaroJonathan D. PowellFabio LucianiJoseph A. TrapaniRicky W. JohnstoneAxel KalliesChristopher C. GoodnowIan A. ParishNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mayura V. Wagle Stephin J. Vervoort Madison J. Kelly Willem Van Der Byl Timothy J. Peters Ben P. Martin Luciano G. Martelotto Simone Nüssing Kelly M. Ramsbottom James R. Torpy Deborah Knight Sinead Reading Kevin Thia Lisa A. Miosge Debbie R. Howard Renee Gloury Sarah S. Gabriel Daniel T. Utzschneider Jane Oliaro Jonathan D. Powell Fabio Luciani Joseph A. Trapani Ricky W. Johnstone Axel Kallies Christopher C. Goodnow Ian A. Parish Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance
description	Exhausted T cells arise when chronic activation triggers functional defects. Here the authors show that chronic antigenic stimulation in both tumour and infection models induces the expression of EGR2, which drives and stabilises exhausted cell epigenetic and transcriptional identity.
format	article
author	Mayura V. Wagle Stephin J. Vervoort Madison J. Kelly Willem Van Der Byl Timothy J. Peters Ben P. Martin Luciano G. Martelotto Simone Nüssing Kelly M. Ramsbottom James R. Torpy Deborah Knight Sinead Reading Kevin Thia Lisa A. Miosge Debbie R. Howard Renee Gloury Sarah S. Gabriel Daniel T. Utzschneider Jane Oliaro Jonathan D. Powell Fabio Luciani Joseph A. Trapani Ricky W. Johnstone Axel Kallies Christopher C. Goodnow Ian A. Parish
author_facet	Mayura V. Wagle Stephin J. Vervoort Madison J. Kelly Willem Van Der Byl Timothy J. Peters Ben P. Martin Luciano G. Martelotto Simone Nüssing Kelly M. Ramsbottom James R. Torpy Deborah Knight Sinead Reading Kevin Thia Lisa A. Miosge Debbie R. Howard Renee Gloury Sarah S. Gabriel Daniel T. Utzschneider Jane Oliaro Jonathan D. Powell Fabio Luciani Joseph A. Trapani Ricky W. Johnstone Axel Kallies Christopher C. Goodnow Ian A. Parish
author_sort	Mayura V. Wagle
title	Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance
title_short	Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance
title_full	Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance
title_fullStr	Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance
title_full_unstemmed	Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance
title_sort	antigen-driven egr2 expression is required for exhausted cd8+ t cell stability and maintenance
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/835402bfc1a5448994d0c742c77cfabd
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Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance

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