Polymer physics indicates chromatin folding variability across single-cells results from state degeneracy in phase separation

The molecular and physical mechanisms underlying chromatin folding at the single DNA molecule level remain poorly understood. Here, the authors use polymer modeling to investigate the conformations of two 2Mb-wide DNA loci in normal and cohesin depleted cells, and provide evidence that the architect...

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Autores principales:	Mattia Conte, Luca Fiorillo, Simona Bianco, Andrea M. Chiariello, Andrea Esposito, Mario Nicodemi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/83550059761641128b264d751599f703
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spelling	oai:doaj.org-article:83550059761641128b264d751599f7032021-12-02T16:10:52ZPolymer physics indicates chromatin folding variability across single-cells results from state degeneracy in phase separation10.1038/s41467-020-17141-42041-1723https://doaj.org/article/83550059761641128b264d751599f7032020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17141-4https://doaj.org/toc/2041-1723The molecular and physical mechanisms underlying chromatin folding at the single DNA molecule level remain poorly understood. Here, the authors use polymer modeling to investigate the conformations of two 2Mb-wide DNA loci in normal and cohesin depleted cells, and provide evidence that the architecture of the studied loci is controlled by a thermodynamics mechanism of polymer phase separation whereby chromatin self-assembles in segregated globules.Mattia ConteLuca FiorilloSimona BiancoAndrea M. ChiarielloAndrea EspositoMario NicodemiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mattia Conte Luca Fiorillo Simona Bianco Andrea M. Chiariello Andrea Esposito Mario Nicodemi Polymer physics indicates chromatin folding variability across single-cells results from state degeneracy in phase separation
description	The molecular and physical mechanisms underlying chromatin folding at the single DNA molecule level remain poorly understood. Here, the authors use polymer modeling to investigate the conformations of two 2Mb-wide DNA loci in normal and cohesin depleted cells, and provide evidence that the architecture of the studied loci is controlled by a thermodynamics mechanism of polymer phase separation whereby chromatin self-assembles in segregated globules.
format	article
author	Mattia Conte Luca Fiorillo Simona Bianco Andrea M. Chiariello Andrea Esposito Mario Nicodemi
author_facet	Mattia Conte Luca Fiorillo Simona Bianco Andrea M. Chiariello Andrea Esposito Mario Nicodemi
author_sort	Mattia Conte
title	Polymer physics indicates chromatin folding variability across single-cells results from state degeneracy in phase separation
title_short	Polymer physics indicates chromatin folding variability across single-cells results from state degeneracy in phase separation
title_full	Polymer physics indicates chromatin folding variability across single-cells results from state degeneracy in phase separation
title_fullStr	Polymer physics indicates chromatin folding variability across single-cells results from state degeneracy in phase separation
title_full_unstemmed	Polymer physics indicates chromatin folding variability across single-cells results from state degeneracy in phase separation
title_sort	polymer physics indicates chromatin folding variability across single-cells results from state degeneracy in phase separation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/83550059761641128b264d751599f703
work_keys_str_mv	AT mattiaconte polymerphysicsindicateschromatinfoldingvariabilityacrosssinglecellsresultsfromstatedegeneracyinphaseseparation AT lucafiorillo polymerphysicsindicateschromatinfoldingvariabilityacrosssinglecellsresultsfromstatedegeneracyinphaseseparation AT simonabianco polymerphysicsindicateschromatinfoldingvariabilityacrosssinglecellsresultsfromstatedegeneracyinphaseseparation AT andreamchiariello polymerphysicsindicateschromatinfoldingvariabilityacrosssinglecellsresultsfromstatedegeneracyinphaseseparation AT andreaesposito polymerphysicsindicateschromatinfoldingvariabilityacrosssinglecellsresultsfromstatedegeneracyinphaseseparation AT marionicodemi polymerphysicsindicateschromatinfoldingvariabilityacrosssinglecellsresultsfromstatedegeneracyinphaseseparation
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Polymer physics indicates chromatin folding variability across single-cells results from state degeneracy in phase separation

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