Irradiation stability and cytotoxicity of gold nanoparticles for radiotherapy

Xiao-Dong Zhang1, Mei-Li Guo2, Hong-Ying Wu1, Yuan-Ming Sun1, Yan-Qiu Ding1, Xin Feng1, Liang-An Zhang11Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, People&rsquo;s Republic of China; 2Department of Physics, Tianjin Institute...

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Autores principales:	Xiao-Dong Zhang, Mei-Li Guo, Hong-Ying Wu, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/835532c652674b83b32530f47736d028
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spelling	oai:doaj.org-article:835532c652674b83b32530f47736d0282021-12-02T02:41:51ZIrradiation stability and cytotoxicity of gold nanoparticles for radiotherapy1176-91141178-2013https://doaj.org/article/835532c652674b83b32530f47736d0282009-09-01T00:00:00Zhttp://www.dovepress.com/irradiation-stability-and-cytotoxicity-of-gold-nanoparticles-for-radio-a3508https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Xiao-Dong Zhang1, Mei-Li Guo2, Hong-Ying Wu1, Yuan-Ming Sun1, Yan-Qiu Ding1, Xin Feng1, Liang-An Zhang11Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, People&rsquo;s Republic of China; 2Department of Physics, Tianjin Institute of Urban Construction, Tianjin, People&rsquo;s Republic of ChinaAbstract: Gold nanoparticles are promising as a kind of novel radiosensitizer in radiotherapy. If gold nanoparticles are shown to have good irradiation stability and biocompatibility, they would play an important role in radiotherapy. In this work, we investigated irradiation effects of gold nanoparticles under 2&ndash;10 kR gamma irradiation and cytotoxicity of gold nanoparticles with human K562 cells by using Cell Titre-Glo&trade; luminescent cell viability assay. The results revealed that gamma irradiation had not induced any obvious instability and size variations in gold nanoparticles. We found that gold nanoparticles showed excellent radiation hardness with an absorbed dose conversation factor of 9.491 rad/R. Meanwhile, the surface plasmon resonance of gold nanoparticles was enhanced obviously after 2&ndash;10 kR gamma irradiation. Subsequently, cytotoxicity tests indicated that the extremely high concentration of gold nanoparticles could cause a sharp decrease in K562 cell viability, while the low concentration of gold nanoparticles had no obvious influence on the cell viability. Our results revealed that gold nanoparticles were stable under high-energy ray irradiation and showed concentration-dependent cytotoxicity.Keywords: gold nanoparticles, gamma ray effects, colloids, cytotoxicity Xiao-Dong ZhangMei-Li GuoHong-Ying Wuet alDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2009, Iss default, Pp 165-173 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Xiao-Dong Zhang Mei-Li Guo Hong-Ying Wu et al Irradiation stability and cytotoxicity of gold nanoparticles for radiotherapy
description	Xiao-Dong Zhang1, Mei-Li Guo2, Hong-Ying Wu1, Yuan-Ming Sun1, Yan-Qiu Ding1, Xin Feng1, Liang-An Zhang11Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, People&rsquo;s Republic of China; 2Department of Physics, Tianjin Institute of Urban Construction, Tianjin, People&rsquo;s Republic of ChinaAbstract: Gold nanoparticles are promising as a kind of novel radiosensitizer in radiotherapy. If gold nanoparticles are shown to have good irradiation stability and biocompatibility, they would play an important role in radiotherapy. In this work, we investigated irradiation effects of gold nanoparticles under 2&ndash;10 kR gamma irradiation and cytotoxicity of gold nanoparticles with human K562 cells by using Cell Titre-Glo&trade; luminescent cell viability assay. The results revealed that gamma irradiation had not induced any obvious instability and size variations in gold nanoparticles. We found that gold nanoparticles showed excellent radiation hardness with an absorbed dose conversation factor of 9.491 rad/R. Meanwhile, the surface plasmon resonance of gold nanoparticles was enhanced obviously after 2&ndash;10 kR gamma irradiation. Subsequently, cytotoxicity tests indicated that the extremely high concentration of gold nanoparticles could cause a sharp decrease in K562 cell viability, while the low concentration of gold nanoparticles had no obvious influence on the cell viability. Our results revealed that gold nanoparticles were stable under high-energy ray irradiation and showed concentration-dependent cytotoxicity.Keywords: gold nanoparticles, gamma ray effects, colloids, cytotoxicity
format	article
author	Xiao-Dong Zhang Mei-Li Guo Hong-Ying Wu et al
author_facet	Xiao-Dong Zhang Mei-Li Guo Hong-Ying Wu et al
author_sort	Xiao-Dong Zhang
title	Irradiation stability and cytotoxicity of gold nanoparticles for radiotherapy
title_short	Irradiation stability and cytotoxicity of gold nanoparticles for radiotherapy
title_full	Irradiation stability and cytotoxicity of gold nanoparticles for radiotherapy
title_fullStr	Irradiation stability and cytotoxicity of gold nanoparticles for radiotherapy
title_full_unstemmed	Irradiation stability and cytotoxicity of gold nanoparticles for radiotherapy
title_sort	irradiation stability and cytotoxicity of gold nanoparticles for radiotherapy
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/835532c652674b83b32530f47736d028
work_keys_str_mv	AT xiaodongzhang irradiationstabilityandcytotoxicityofgoldnanoparticlesforradiotherapy AT meiliguo irradiationstabilityandcytotoxicityofgoldnanoparticlesforradiotherapy AT hongyingwu irradiationstabilityandcytotoxicityofgoldnanoparticlesforradiotherapy AT etal irradiationstabilityandcytotoxicityofgoldnanoparticlesforradiotherapy
_version_	1718402230769418240

Irradiation stability and cytotoxicity of gold nanoparticles for radiotherapy

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