Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors

Identifying the mutational landscape of tumours from cell-free DNA in the blood could help diagnostics in cancer. Here, the authors present ichorCNA, software that quantifies tumour content in cell free DNA, and they demonstrate that cell-free DNA whole-exome sequencing is concordant with metastatic...

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Autores principales:	Viktor A. Adalsteinsson, Gavin Ha, Samuel S. Freeman, Atish D. Choudhury, Daniel G. Stover, Heather A. Parsons, Gregory Gydush, Sarah C. Reed, Denisse Rotem, Justin Rhoades, Denis Loginov, Dimitri Livitz, Daniel Rosebrock, Ignaty Leshchiner, Jaegil Kim, Chip Stewart, Mara Rosenberg, Joshua M. Francis, Cheng-Zhong Zhang, Ofir Cohen, Coyin Oh, Huiming Ding, Paz Polak, Max Lloyd, Sairah Mahmud, Karla Helvie, Margaret S. Merrill, Rebecca A. Santiago, Edward P. O’Connor, Seong H. Jeong, Rachel Leeson, Rachel M. Barry, Joseph F. Kramkowski, Zhenwei Zhang, Laura Polacek, Jens G. Lohr, Molly Schleicher, Emily Lipscomb, Andrea Saltzman, Nelly M. Oliver, Lori Marini, Adrienne G. Waks, Lauren C. Harshman, Sara M. Tolaney, Eliezer M. Van Allen, Eric P. Winer, Nancy U. Lin, Mari Nakabayashi, Mary-Ellen Taplin, Cory M. Johannessen, Levi A. Garraway, Todd R. Golub, Jesse S. Boehm, Nikhil Wagle, Gad Getz, J. Christopher Love, Matthew Meyerson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8356e743a9994304930b464f7882be11
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spelling	oai:doaj.org-article:8356e743a9994304930b464f7882be112021-12-02T15:38:57ZScalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors10.1038/s41467-017-00965-y2041-1723https://doaj.org/article/8356e743a9994304930b464f7882be112017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00965-yhttps://doaj.org/toc/2041-1723Identifying the mutational landscape of tumours from cell-free DNA in the blood could help diagnostics in cancer. Here, the authors present ichorCNA, software that quantifies tumour content in cell free DNA, and they demonstrate that cell-free DNA whole-exome sequencing is concordant with metastatic tumour whole-exome sequencing.Viktor A. AdalsteinssonGavin HaSamuel S. FreemanAtish D. ChoudhuryDaniel G. StoverHeather A. ParsonsGregory GydushSarah C. ReedDenisse RotemJustin RhoadesDenis LoginovDimitri LivitzDaniel RosebrockIgnaty LeshchinerJaegil KimChip StewartMara RosenbergJoshua M. FrancisCheng-Zhong ZhangOfir CohenCoyin OhHuiming DingPaz PolakMax LloydSairah MahmudKarla HelvieMargaret S. MerrillRebecca A. SantiagoEdward P. O’ConnorSeong H. JeongRachel LeesonRachel M. BarryJoseph F. KramkowskiZhenwei ZhangLaura PolacekJens G. LohrMolly SchleicherEmily LipscombAndrea SaltzmanNelly M. OliverLori MariniAdrienne G. WaksLauren C. HarshmanSara M. TolaneyEliezer M. Van AllenEric P. WinerNancy U. LinMari NakabayashiMary-Ellen TaplinCory M. JohannessenLevi A. GarrawayTodd R. GolubJesse S. BoehmNikhil WagleGad GetzJ. Christopher LoveMatthew MeyersonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Viktor A. Adalsteinsson Gavin Ha Samuel S. Freeman Atish D. Choudhury Daniel G. Stover Heather A. Parsons Gregory Gydush Sarah C. Reed Denisse Rotem Justin Rhoades Denis Loginov Dimitri Livitz Daniel Rosebrock Ignaty Leshchiner Jaegil Kim Chip Stewart Mara Rosenberg Joshua M. Francis Cheng-Zhong Zhang Ofir Cohen Coyin Oh Huiming Ding Paz Polak Max Lloyd Sairah Mahmud Karla Helvie Margaret S. Merrill Rebecca A. Santiago Edward P. O’Connor Seong H. Jeong Rachel Leeson Rachel M. Barry Joseph F. Kramkowski Zhenwei Zhang Laura Polacek Jens G. Lohr Molly Schleicher Emily Lipscomb Andrea Saltzman Nelly M. Oliver Lori Marini Adrienne G. Waks Lauren C. Harshman Sara M. Tolaney Eliezer M. Van Allen Eric P. Winer Nancy U. Lin Mari Nakabayashi Mary-Ellen Taplin Cory M. Johannessen Levi A. Garraway Todd R. Golub Jesse S. Boehm Nikhil Wagle Gad Getz J. Christopher Love Matthew Meyerson Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors
description	Identifying the mutational landscape of tumours from cell-free DNA in the blood could help diagnostics in cancer. Here, the authors present ichorCNA, software that quantifies tumour content in cell free DNA, and they demonstrate that cell-free DNA whole-exome sequencing is concordant with metastatic tumour whole-exome sequencing.
format	article
author	Viktor A. Adalsteinsson Gavin Ha Samuel S. Freeman Atish D. Choudhury Daniel G. Stover Heather A. Parsons Gregory Gydush Sarah C. Reed Denisse Rotem Justin Rhoades Denis Loginov Dimitri Livitz Daniel Rosebrock Ignaty Leshchiner Jaegil Kim Chip Stewart Mara Rosenberg Joshua M. Francis Cheng-Zhong Zhang Ofir Cohen Coyin Oh Huiming Ding Paz Polak Max Lloyd Sairah Mahmud Karla Helvie Margaret S. Merrill Rebecca A. Santiago Edward P. O’Connor Seong H. Jeong Rachel Leeson Rachel M. Barry Joseph F. Kramkowski Zhenwei Zhang Laura Polacek Jens G. Lohr Molly Schleicher Emily Lipscomb Andrea Saltzman Nelly M. Oliver Lori Marini Adrienne G. Waks Lauren C. Harshman Sara M. Tolaney Eliezer M. Van Allen Eric P. Winer Nancy U. Lin Mari Nakabayashi Mary-Ellen Taplin Cory M. Johannessen Levi A. Garraway Todd R. Golub Jesse S. Boehm Nikhil Wagle Gad Getz J. Christopher Love Matthew Meyerson
author_facet	Viktor A. Adalsteinsson Gavin Ha Samuel S. Freeman Atish D. Choudhury Daniel G. Stover Heather A. Parsons Gregory Gydush Sarah C. Reed Denisse Rotem Justin Rhoades Denis Loginov Dimitri Livitz Daniel Rosebrock Ignaty Leshchiner Jaegil Kim Chip Stewart Mara Rosenberg Joshua M. Francis Cheng-Zhong Zhang Ofir Cohen Coyin Oh Huiming Ding Paz Polak Max Lloyd Sairah Mahmud Karla Helvie Margaret S. Merrill Rebecca A. Santiago Edward P. O’Connor Seong H. Jeong Rachel Leeson Rachel M. Barry Joseph F. Kramkowski Zhenwei Zhang Laura Polacek Jens G. Lohr Molly Schleicher Emily Lipscomb Andrea Saltzman Nelly M. Oliver Lori Marini Adrienne G. Waks Lauren C. Harshman Sara M. Tolaney Eliezer M. Van Allen Eric P. Winer Nancy U. Lin Mari Nakabayashi Mary-Ellen Taplin Cory M. Johannessen Levi A. Garraway Todd R. Golub Jesse S. Boehm Nikhil Wagle Gad Getz J. Christopher Love Matthew Meyerson
author_sort	Viktor A. Adalsteinsson
title	Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors
title_short	Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors
title_full	Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors
title_fullStr	Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors
title_full_unstemmed	Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors
title_sort	scalable whole-exome sequencing of cell-free dna reveals high concordance with metastatic tumors
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8356e743a9994304930b464f7882be11
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Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors

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