Erythrocyte Deformability and Na,K-ATPase Activity in Various Pathophysiological Situations and Their Protection by Selected Nutritional Antioxidants in Humans

The physicochemical and functional properties of erythrocytes are worsened in a variety of diseases. Erythrocyte deformability refers to their ability to adjust their shape according to external forces exerted against them in the circulation. It is influenced by the functionality of the Na,K-ATPase...

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Autores principales:	Jana Radosinska, Norbert Vrbjar
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	erythrocytes deformability Na,K-ATPase pathophysiology antioxidants vitamins Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/835837b2720d479bab0d4d63cc15ef61
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id	oai:doaj.org-article:835837b2720d479bab0d4d63cc15ef61
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spelling	oai:doaj.org-article:835837b2720d479bab0d4d63cc15ef612021-11-11T17:20:29ZErythrocyte Deformability and Na,K-ATPase Activity in Various Pathophysiological Situations and Their Protection by Selected Nutritional Antioxidants in Humans10.3390/ijms2221119241422-00671661-6596https://doaj.org/article/835837b2720d479bab0d4d63cc15ef612021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11924https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The physicochemical and functional properties of erythrocytes are worsened in a variety of diseases. Erythrocyte deformability refers to their ability to adjust their shape according to external forces exerted against them in the circulation. It is influenced by the functionality of the Na,K-ATPase enzyme, which is localized in their membranes. The proposed review is focused on knowledge regarding changes in erythrocyte Na,K-ATPase activity, and their impact on erythrocyte deformability in various pathophysiological situations observed exclusively in human studies, as well as on the potential erytroprotective effects of selected natural nutritional antioxidants. A clear link between the erythrocyte properties and the parameters of oxidative stress was observed. The undesirable consequences of oxidative stress on erythrocyte quality and hemorheology could be at least partially prevented by intake of diverse antioxidants occurring naturally in foodstuffs. Despite intensive research concerning the effect of antioxidants, only a small number of investigations on erythrocyte properties in humans is available in databases. It is worth shifting attention from animal and in vitro experiments and focusing more on antioxidant administration in human studies in order to establish what type of antioxidant, in what concentration, and in which individuals it may provide a beneficial effect on the human organism, by protecting erythrocyte properties.Jana RadosinskaNorbert VrbjarMDPI AGarticleerythrocytesdeformabilityNa,K-ATPasepathophysiologyantioxidantsvitaminsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11924, p 11924 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	erythrocytes deformability Na,K-ATPase pathophysiology antioxidants vitamins Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	erythrocytes deformability Na,K-ATPase pathophysiology antioxidants vitamins Biology (General) QH301-705.5 Chemistry QD1-999 Jana Radosinska Norbert Vrbjar Erythrocyte Deformability and Na,K-ATPase Activity in Various Pathophysiological Situations and Their Protection by Selected Nutritional Antioxidants in Humans
description	The physicochemical and functional properties of erythrocytes are worsened in a variety of diseases. Erythrocyte deformability refers to their ability to adjust their shape according to external forces exerted against them in the circulation. It is influenced by the functionality of the Na,K-ATPase enzyme, which is localized in their membranes. The proposed review is focused on knowledge regarding changes in erythrocyte Na,K-ATPase activity, and their impact on erythrocyte deformability in various pathophysiological situations observed exclusively in human studies, as well as on the potential erytroprotective effects of selected natural nutritional antioxidants. A clear link between the erythrocyte properties and the parameters of oxidative stress was observed. The undesirable consequences of oxidative stress on erythrocyte quality and hemorheology could be at least partially prevented by intake of diverse antioxidants occurring naturally in foodstuffs. Despite intensive research concerning the effect of antioxidants, only a small number of investigations on erythrocyte properties in humans is available in databases. It is worth shifting attention from animal and in vitro experiments and focusing more on antioxidant administration in human studies in order to establish what type of antioxidant, in what concentration, and in which individuals it may provide a beneficial effect on the human organism, by protecting erythrocyte properties.
format	article
author	Jana Radosinska Norbert Vrbjar
author_facet	Jana Radosinska Norbert Vrbjar
author_sort	Jana Radosinska
title	Erythrocyte Deformability and Na,K-ATPase Activity in Various Pathophysiological Situations and Their Protection by Selected Nutritional Antioxidants in Humans
title_short	Erythrocyte Deformability and Na,K-ATPase Activity in Various Pathophysiological Situations and Their Protection by Selected Nutritional Antioxidants in Humans
title_full	Erythrocyte Deformability and Na,K-ATPase Activity in Various Pathophysiological Situations and Their Protection by Selected Nutritional Antioxidants in Humans
title_fullStr	Erythrocyte Deformability and Na,K-ATPase Activity in Various Pathophysiological Situations and Their Protection by Selected Nutritional Antioxidants in Humans
title_full_unstemmed	Erythrocyte Deformability and Na,K-ATPase Activity in Various Pathophysiological Situations and Their Protection by Selected Nutritional Antioxidants in Humans
title_sort	erythrocyte deformability and na,k-atpase activity in various pathophysiological situations and their protection by selected nutritional antioxidants in humans
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/835837b2720d479bab0d4d63cc15ef61
work_keys_str_mv	AT janaradosinska erythrocytedeformabilityandnakatpaseactivityinvariouspathophysiologicalsituationsandtheirprotectionbyselectednutritionalantioxidantsinhumans AT norbertvrbjar erythrocytedeformabilityandnakatpaseactivityinvariouspathophysiologicalsituationsandtheirprotectionbyselectednutritionalantioxidantsinhumans
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Erythrocyte Deformability and Na,K-ATPase Activity in Various Pathophysiological Situations and Their Protection by Selected Nutritional Antioxidants in Humans

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