The containment of potential outbreaks triggered by imported Chikungunya cases in Italy: a cost utility epidemiological assessment of vector control measures

Abstract The arrival of infected travelers from endemic regions can trigger sustained autochthonous transmission of mosquito-borne pathogens in Europe. In 2007 a Chikungunya outbreak was observed in central Italy, mostly affecting two villages characterised by a high density of Aedes albopictus. The...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	F. Trentini, P. Poletti, F. Baldacchino, A. Drago, F. Montarsi, G. Capelli, A. Rizzoli, R. Rosà, C. Rizzo, S. Merler, A. Melegaro
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/835c6088ee1a4be992e72c2b3088a0d0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:835c6088ee1a4be992e72c2b3088a0d0
record_format	dspace
spelling	oai:doaj.org-article:835c6088ee1a4be992e72c2b3088a0d02021-12-02T11:41:04ZThe containment of potential outbreaks triggered by imported Chikungunya cases in Italy: a cost utility epidemiological assessment of vector control measures10.1038/s41598-018-27443-92045-2322https://doaj.org/article/835c6088ee1a4be992e72c2b3088a0d02018-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-27443-9https://doaj.org/toc/2045-2322Abstract The arrival of infected travelers from endemic regions can trigger sustained autochthonous transmission of mosquito-borne pathogens in Europe. In 2007 a Chikungunya outbreak was observed in central Italy, mostly affecting two villages characterised by a high density of Aedes albopictus. The outbreak was mitigated through intervention strategies reducing the mosquito abundance. Ten years later, in 2017, sustained Chikungunya transmission was documented in both central and southern Italy. The proposed analysis identifies suitable reactive measures for the containment and mitigation of future epidemics by combining epidemiological modeling with a health economic approach, considering different arrival times of imported infections and possible delays in the notification of cases. Obtained estimates suggest that, if the first notification will occur in the middle of the mosquito breeding season, the combination of larvicides, adulticides and breeding sites removal represents the optimal strategy. In particular, we found that interventions implemented in 2007 were cost-effective, with about 3200 prevented cases, 1450 DALYs averted and €13.5 M saved. Moreover, larvicides are proven to be more cost beneficial in early summer and warmer seasons, while adulticides should be preferred in autumn and colder seasons. Our results provide useful indications supporting urgent decision-making of public health authorities in response to emerging mosquito-borne epidemics.F. TrentiniP. PolettiF. BaldacchinoA. DragoF. MontarsiG. CapelliA. RizzoliR. RosàC. RizzoS. MerlerA. MelegaroNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q F. Trentini P. Poletti F. Baldacchino A. Drago F. Montarsi G. Capelli A. Rizzoli R. Rosà C. Rizzo S. Merler A. Melegaro The containment of potential outbreaks triggered by imported Chikungunya cases in Italy: a cost utility epidemiological assessment of vector control measures
description	Abstract The arrival of infected travelers from endemic regions can trigger sustained autochthonous transmission of mosquito-borne pathogens in Europe. In 2007 a Chikungunya outbreak was observed in central Italy, mostly affecting two villages characterised by a high density of Aedes albopictus. The outbreak was mitigated through intervention strategies reducing the mosquito abundance. Ten years later, in 2017, sustained Chikungunya transmission was documented in both central and southern Italy. The proposed analysis identifies suitable reactive measures for the containment and mitigation of future epidemics by combining epidemiological modeling with a health economic approach, considering different arrival times of imported infections and possible delays in the notification of cases. Obtained estimates suggest that, if the first notification will occur in the middle of the mosquito breeding season, the combination of larvicides, adulticides and breeding sites removal represents the optimal strategy. In particular, we found that interventions implemented in 2007 were cost-effective, with about 3200 prevented cases, 1450 DALYs averted and €13.5 M saved. Moreover, larvicides are proven to be more cost beneficial in early summer and warmer seasons, while adulticides should be preferred in autumn and colder seasons. Our results provide useful indications supporting urgent decision-making of public health authorities in response to emerging mosquito-borne epidemics.
format	article
author	F. Trentini P. Poletti F. Baldacchino A. Drago F. Montarsi G. Capelli A. Rizzoli R. Rosà C. Rizzo S. Merler A. Melegaro
author_facet	F. Trentini P. Poletti F. Baldacchino A. Drago F. Montarsi G. Capelli A. Rizzoli R. Rosà C. Rizzo S. Merler A. Melegaro
author_sort	F. Trentini
title	The containment of potential outbreaks triggered by imported Chikungunya cases in Italy: a cost utility epidemiological assessment of vector control measures
title_short	The containment of potential outbreaks triggered by imported Chikungunya cases in Italy: a cost utility epidemiological assessment of vector control measures
title_full	The containment of potential outbreaks triggered by imported Chikungunya cases in Italy: a cost utility epidemiological assessment of vector control measures
title_fullStr	The containment of potential outbreaks triggered by imported Chikungunya cases in Italy: a cost utility epidemiological assessment of vector control measures
title_full_unstemmed	The containment of potential outbreaks triggered by imported Chikungunya cases in Italy: a cost utility epidemiological assessment of vector control measures
title_sort	containment of potential outbreaks triggered by imported chikungunya cases in italy: a cost utility epidemiological assessment of vector control measures
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/835c6088ee1a4be992e72c2b3088a0d0
work_keys_str_mv	AT ftrentini thecontainmentofpotentialoutbreakstriggeredbyimportedchikungunyacasesinitalyacostutilityepidemiologicalassessmentofvectorcontrolmeasures AT ppoletti thecontainmentofpotentialoutbreakstriggeredbyimportedchikungunyacasesinitalyacostutilityepidemiologicalassessmentofvectorcontrolmeasures AT fbaldacchino thecontainmentofpotentialoutbreakstriggeredbyimportedchikungunyacasesinitalyacostutilityepidemiologicalassessmentofvectorcontrolmeasures AT adrago thecontainmentofpotentialoutbreakstriggeredbyimportedchikungunyacasesinitalyacostutilityepidemiologicalassessmentofvectorcontrolmeasures AT fmontarsi thecontainmentofpotentialoutbreakstriggeredbyimportedchikungunyacasesinitalyacostutilityepidemiologicalassessmentofvectorcontrolmeasures AT gcapelli thecontainmentofpotentialoutbreakstriggeredbyimportedchikungunyacasesinitalyacostutilityepidemiologicalassessmentofvectorcontrolmeasures AT arizzoli thecontainmentofpotentialoutbreakstriggeredbyimportedchikungunyacasesinitalyacostutilityepidemiologicalassessmentofvectorcontrolmeasures AT rrosa thecontainmentofpotentialoutbreakstriggeredbyimportedchikungunyacasesinitalyacostutilityepidemiologicalassessmentofvectorcontrolmeasures AT crizzo thecontainmentofpotentialoutbreakstriggeredbyimportedchikungunyacasesinitalyacostutilityepidemiologicalassessmentofvectorcontrolmeasures AT smerler thecontainmentofpotentialoutbreakstriggeredbyimportedchikungunyacasesinitalyacostutilityepidemiologicalassessmentofvectorcontrolmeasures AT amelegaro thecontainmentofpotentialoutbreakstriggeredbyimportedchikungunyacasesinitalyacostutilityepidemiologicalassessmentofvectorcontrolmeasures AT ftrentini containmentofpotentialoutbreakstriggeredbyimportedchikungunyacasesinitalyacostutilityepidemiologicalassessmentofvectorcontrolmeasures AT ppoletti containmentofpotentialoutbreakstriggeredbyimportedchikungunyacasesinitalyacostutilityepidemiologicalassessmentofvectorcontrolmeasures AT fbaldacchino containmentofpotentialoutbreakstriggeredbyimportedchikungunyacasesinitalyacostutilityepidemiologicalassessmentofvectorcontrolmeasures AT adrago containmentofpotentialoutbreakstriggeredbyimportedchikungunyacasesinitalyacostutilityepidemiologicalassessmentofvectorcontrolmeasures AT fmontarsi containmentofpotentialoutbreakstriggeredbyimportedchikungunyacasesinitalyacostutilityepidemiologicalassessmentofvectorcontrolmeasures AT gcapelli containmentofpotentialoutbreakstriggeredbyimportedchikungunyacasesinitalyacostutilityepidemiologicalassessmentofvectorcontrolmeasures AT arizzoli containmentofpotentialoutbreakstriggeredbyimportedchikungunyacasesinitalyacostutilityepidemiologicalassessmentofvectorcontrolmeasures AT rrosa containmentofpotentialoutbreakstriggeredbyimportedchikungunyacasesinitalyacostutilityepidemiologicalassessmentofvectorcontrolmeasures AT crizzo containmentofpotentialoutbreakstriggeredbyimportedchikungunyacasesinitalyacostutilityepidemiologicalassessmentofvectorcontrolmeasures AT smerler containmentofpotentialoutbreakstriggeredbyimportedchikungunyacasesinitalyacostutilityepidemiologicalassessmentofvectorcontrolmeasures AT amelegaro containmentofpotentialoutbreakstriggeredbyimportedchikungunyacasesinitalyacostutilityepidemiologicalassessmentofvectorcontrolmeasures
_version_	1718395469814562816

The containment of potential outbreaks triggered by imported Chikungunya cases in Italy: a cost utility epidemiological assessment of vector control measures

Ejemplares similares