Pseudophosphatases as Regulators of MAPK Signaling

Mitogen-activated protein kinase (MAPK) signaling pathways are highly conserved regulators of eukaryotic cell function. These enzymes regulate many biological processes, including the cell cycle, apoptosis, differentiation, protein biosynthesis, and oncogenesis; therefore, tight control of the activ...

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Autores principales:	Emma Marie Wilber Hepworth, Shantá D. Hinton
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	mitogen-activated protein kinase (MAPK) extracellular signal-regulated kinase (ERK) kinase protein tyrosine phosphatases (PTPs) pseudophosphatase dual-specificity phosphatases (DUSPs) Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/835e0902d0d94b4caa4c9c357e8eac20
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spelling	oai:doaj.org-article:835e0902d0d94b4caa4c9c357e8eac202021-11-25T17:58:11ZPseudophosphatases as Regulators of MAPK Signaling10.3390/ijms2222125951422-00671661-6596https://doaj.org/article/835e0902d0d94b4caa4c9c357e8eac202021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12595https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Mitogen-activated protein kinase (MAPK) signaling pathways are highly conserved regulators of eukaryotic cell function. These enzymes regulate many biological processes, including the cell cycle, apoptosis, differentiation, protein biosynthesis, and oncogenesis; therefore, tight control of the activity of MAPK is critical. Kinases and phosphatases are well established as MAPK activators and inhibitors, respectively. Kinases phosphorylate MAPKs, initiating and controlling the amplitude of the activation. In contrast, MAPK phosphatases (MKPs) dephosphorylate MAPKs, downregulating and controlling the duration of the signal. In addition, within the past decade, pseudoenzymes of these two families, pseudokinases and pseudophosphatases, have emerged as bona fide signaling regulators. This review discusses the role of pseudophosphatases in MAPK signaling, highlighting the function of phosphoserine/threonine/tyrosine-interacting protein (STYX) and TAK1-binding protein (TAB 1) in regulating MAPKs. Finally, a new paradigm is considered for this well-studied cellular pathway, and signal transduction pathways in general.Emma Marie Wilber HepworthShantá D. HintonMDPI AGarticlemitogen-activated protein kinase (MAPK)extracellular signal-regulated kinase (ERK)kinaseprotein tyrosine phosphatases (PTPs)pseudophosphatasedual-specificity phosphatases (DUSPs)Biology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12595, p 12595 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mitogen-activated protein kinase (MAPK) extracellular signal-regulated kinase (ERK) kinase protein tyrosine phosphatases (PTPs) pseudophosphatase dual-specificity phosphatases (DUSPs) Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	mitogen-activated protein kinase (MAPK) extracellular signal-regulated kinase (ERK) kinase protein tyrosine phosphatases (PTPs) pseudophosphatase dual-specificity phosphatases (DUSPs) Biology (General) QH301-705.5 Chemistry QD1-999 Emma Marie Wilber Hepworth Shantá D. Hinton Pseudophosphatases as Regulators of MAPK Signaling
description	Mitogen-activated protein kinase (MAPK) signaling pathways are highly conserved regulators of eukaryotic cell function. These enzymes regulate many biological processes, including the cell cycle, apoptosis, differentiation, protein biosynthesis, and oncogenesis; therefore, tight control of the activity of MAPK is critical. Kinases and phosphatases are well established as MAPK activators and inhibitors, respectively. Kinases phosphorylate MAPKs, initiating and controlling the amplitude of the activation. In contrast, MAPK phosphatases (MKPs) dephosphorylate MAPKs, downregulating and controlling the duration of the signal. In addition, within the past decade, pseudoenzymes of these two families, pseudokinases and pseudophosphatases, have emerged as bona fide signaling regulators. This review discusses the role of pseudophosphatases in MAPK signaling, highlighting the function of phosphoserine/threonine/tyrosine-interacting protein (STYX) and TAK1-binding protein (TAB 1) in regulating MAPKs. Finally, a new paradigm is considered for this well-studied cellular pathway, and signal transduction pathways in general.
format	article
author	Emma Marie Wilber Hepworth Shantá D. Hinton
author_facet	Emma Marie Wilber Hepworth Shantá D. Hinton
author_sort	Emma Marie Wilber Hepworth
title	Pseudophosphatases as Regulators of MAPK Signaling
title_short	Pseudophosphatases as Regulators of MAPK Signaling
title_full	Pseudophosphatases as Regulators of MAPK Signaling
title_fullStr	Pseudophosphatases as Regulators of MAPK Signaling
title_full_unstemmed	Pseudophosphatases as Regulators of MAPK Signaling
title_sort	pseudophosphatases as regulators of mapk signaling
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/835e0902d0d94b4caa4c9c357e8eac20
work_keys_str_mv	AT emmamariewilberhepworth pseudophosphatasesasregulatorsofmapksignaling AT shantadhinton pseudophosphatasesasregulatorsofmapksignaling
_version_	1718411813998034944

Pseudophosphatases as Regulators of MAPK Signaling

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