New and Emerging Approaches to Better Define Sleep Disruption and Its Consequences

Current approaches to quantify and diagnose sleep disorders and circadian rhythm disruption are imprecise, laborious, and often do not relate well to key clinical and health outcomes. Newer emerging approaches that aim to overcome the practical and technical constraints of current sleep metrics have...

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Autores principales:	Bastien Lechat, Hannah Scott, Ganesh Naik, Kristy Hansen, Duc Phuc Nguyen, Andrew Vakulin, Peter Catcheside, Danny J. Eckert
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	sleep disordered breathing sleep apnea insomnia circadian rhythm polysomnography signal processing Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/835ef379352a4afa8bb8a7bb133ab3dd
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spelling	oai:doaj.org-article:835ef379352a4afa8bb8a7bb133ab3dd2021-11-17T12:14:15ZNew and Emerging Approaches to Better Define Sleep Disruption and Its Consequences1662-453X10.3389/fnins.2021.751730https://doaj.org/article/835ef379352a4afa8bb8a7bb133ab3dd2021-10-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.751730/fullhttps://doaj.org/toc/1662-453XCurrent approaches to quantify and diagnose sleep disorders and circadian rhythm disruption are imprecise, laborious, and often do not relate well to key clinical and health outcomes. Newer emerging approaches that aim to overcome the practical and technical constraints of current sleep metrics have considerable potential to better explain sleep disorder pathophysiology and thus to more precisely align diagnostic, treatment and management approaches to underlying pathology. These include more fine-grained and continuous EEG signal feature detection and novel oxygenation metrics to better encapsulate hypoxia duration, frequency, and magnitude readily possible via more advanced data acquisition and scoring algorithm approaches. Recent technological advances may also soon facilitate simple assessment of circadian rhythm physiology at home to enable sleep disorder diagnostics even for “non-circadian rhythm” sleep disorders, such as chronic insomnia and sleep apnea, which in many cases also include a circadian disruption component. Bringing these novel approaches into the clinic and the home settings should be a priority for the field. Modern sleep tracking technology can also further facilitate the transition of sleep diagnostics from the laboratory to the home, where environmental factors such as noise and light could usefully inform clinical decision-making. The “endpoint” of these new and emerging assessments will be better targeted therapies that directly address underlying sleep disorder pathophysiology via an individualized, precision medicine approach. This review outlines the current state-of-the-art in sleep and circadian monitoring and diagnostics and covers several new and emerging approaches to better define sleep disruption and its consequences.Bastien LechatHannah ScottGanesh NaikKristy HansenDuc Phuc NguyenAndrew VakulinPeter CatchesideDanny J. EckertFrontiers Media S.A.articlesleep disordered breathingsleep apneainsomniacircadian rhythmpolysomnographysignal processingNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sleep disordered breathing sleep apnea insomnia circadian rhythm polysomnography signal processing Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	sleep disordered breathing sleep apnea insomnia circadian rhythm polysomnography signal processing Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Bastien Lechat Hannah Scott Ganesh Naik Kristy Hansen Duc Phuc Nguyen Andrew Vakulin Peter Catcheside Danny J. Eckert New and Emerging Approaches to Better Define Sleep Disruption and Its Consequences
description	Current approaches to quantify and diagnose sleep disorders and circadian rhythm disruption are imprecise, laborious, and often do not relate well to key clinical and health outcomes. Newer emerging approaches that aim to overcome the practical and technical constraints of current sleep metrics have considerable potential to better explain sleep disorder pathophysiology and thus to more precisely align diagnostic, treatment and management approaches to underlying pathology. These include more fine-grained and continuous EEG signal feature detection and novel oxygenation metrics to better encapsulate hypoxia duration, frequency, and magnitude readily possible via more advanced data acquisition and scoring algorithm approaches. Recent technological advances may also soon facilitate simple assessment of circadian rhythm physiology at home to enable sleep disorder diagnostics even for “non-circadian rhythm” sleep disorders, such as chronic insomnia and sleep apnea, which in many cases also include a circadian disruption component. Bringing these novel approaches into the clinic and the home settings should be a priority for the field. Modern sleep tracking technology can also further facilitate the transition of sleep diagnostics from the laboratory to the home, where environmental factors such as noise and light could usefully inform clinical decision-making. The “endpoint” of these new and emerging assessments will be better targeted therapies that directly address underlying sleep disorder pathophysiology via an individualized, precision medicine approach. This review outlines the current state-of-the-art in sleep and circadian monitoring and diagnostics and covers several new and emerging approaches to better define sleep disruption and its consequences.
format	article
author	Bastien Lechat Hannah Scott Ganesh Naik Kristy Hansen Duc Phuc Nguyen Andrew Vakulin Peter Catcheside Danny J. Eckert
author_facet	Bastien Lechat Hannah Scott Ganesh Naik Kristy Hansen Duc Phuc Nguyen Andrew Vakulin Peter Catcheside Danny J. Eckert
author_sort	Bastien Lechat
title	New and Emerging Approaches to Better Define Sleep Disruption and Its Consequences
title_short	New and Emerging Approaches to Better Define Sleep Disruption and Its Consequences
title_full	New and Emerging Approaches to Better Define Sleep Disruption and Its Consequences
title_fullStr	New and Emerging Approaches to Better Define Sleep Disruption and Its Consequences
title_full_unstemmed	New and Emerging Approaches to Better Define Sleep Disruption and Its Consequences
title_sort	new and emerging approaches to better define sleep disruption and its consequences
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/835ef379352a4afa8bb8a7bb133ab3dd
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New and Emerging Approaches to Better Define Sleep Disruption and Its Consequences

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