Efficacy of amniotic membrane-assisted bleb revision for elevated intraocular pressure after filtering surgery

Yoshiaki Kiuchi1, Masahide Yanagi1, Takao Nakamura21Department of Ophthalmology and Visual Sciences, Hiroshima University, Hiroshima, 2Department of Ophthalmology, Otemae Hospital, Osaka, JapanPurpose: To compare the effectiveness of standard revision surgery using mitomycin C (MMC) with revision us...

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Autores principales:	Yoshiaki Kiuchi, Masahide Yanagi, Takao Nakamura
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/835f9f93345646108586573a868b7bcd
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spelling	oai:doaj.org-article:835f9f93345646108586573a868b7bcd2021-12-02T02:55:19ZEfficacy of amniotic membrane-assisted bleb revision for elevated intraocular pressure after filtering surgery1177-54671177-5483https://doaj.org/article/835f9f93345646108586573a868b7bcd2010-07-01T00:00:00Zhttp://www.dovepress.com/efficacy-of-amniotic-membrane-assisted-bleb-revision-for-elevated-intr-a4904https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Yoshiaki Kiuchi1, Masahide Yanagi1, Takao Nakamura21Department of Ophthalmology and Visual Sciences, Hiroshima University, Hiroshima, 2Department of Ophthalmology, Otemae Hospital, Osaka, JapanPurpose: To compare the effectiveness of standard revision surgery using mitomycin C (MMC) with revision using amniotic membrane transplantation and MMC for elevated intraocular pressure (IOP) after trabeculectomy.Patients and methods: A retrospective, nonrandomized comparative study of 36 eyes of 36 patients with a failed trabeculectomy. Patients were divided into two groups, ie, a nonamnion-transplanted group and an amnion-transplanted group. The amniotic membrane was placed on the scleral flap under the conjunctiva in the amnion-transplanted group. Both groups recovered filtration of aqueous humor from the surgical site with the adjunctive use of MMC. The changes in IOP and cumulative survival rate were compared for the two groups. Success was defined as a 30% reduction in IOP from the preoperative IOP and maintenance below 21 mmHg with or without the use of antiglaucomatous agents.Results: The mean preoperative IOP was not significantly different in the two groups. The mean postoperative IOP in the nonamnion group, 12.1 &plusmn; 5.5 mmHg, was significantly lower than the IOP in the amnion group, 16.0 &plusmn; 3.7 mmHg. Survival curves in the two groups did not reach significantly different levels.Conclusions: Conventional surgical bleb revision with MMC can significantly reduce the elevated IOP associated with a failed filtration bleb. The use of an amniotic membrane transplant did not improve the surgical outcome in our cases.Keywords: filtration bleb revision, amniotic membrane, mitomycin C, filtering surgery Yoshiaki KiuchiMasahide YanagiTakao NakamuraDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2010, Iss default, Pp 839-843 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Yoshiaki Kiuchi Masahide Yanagi Takao Nakamura Efficacy of amniotic membrane-assisted bleb revision for elevated intraocular pressure after filtering surgery
description	Yoshiaki Kiuchi1, Masahide Yanagi1, Takao Nakamura21Department of Ophthalmology and Visual Sciences, Hiroshima University, Hiroshima, 2Department of Ophthalmology, Otemae Hospital, Osaka, JapanPurpose: To compare the effectiveness of standard revision surgery using mitomycin C (MMC) with revision using amniotic membrane transplantation and MMC for elevated intraocular pressure (IOP) after trabeculectomy.Patients and methods: A retrospective, nonrandomized comparative study of 36 eyes of 36 patients with a failed trabeculectomy. Patients were divided into two groups, ie, a nonamnion-transplanted group and an amnion-transplanted group. The amniotic membrane was placed on the scleral flap under the conjunctiva in the amnion-transplanted group. Both groups recovered filtration of aqueous humor from the surgical site with the adjunctive use of MMC. The changes in IOP and cumulative survival rate were compared for the two groups. Success was defined as a 30% reduction in IOP from the preoperative IOP and maintenance below 21 mmHg with or without the use of antiglaucomatous agents.Results: The mean preoperative IOP was not significantly different in the two groups. The mean postoperative IOP in the nonamnion group, 12.1 &plusmn; 5.5 mmHg, was significantly lower than the IOP in the amnion group, 16.0 &plusmn; 3.7 mmHg. Survival curves in the two groups did not reach significantly different levels.Conclusions: Conventional surgical bleb revision with MMC can significantly reduce the elevated IOP associated with a failed filtration bleb. The use of an amniotic membrane transplant did not improve the surgical outcome in our cases.Keywords: filtration bleb revision, amniotic membrane, mitomycin C, filtering surgery
format	article
author	Yoshiaki Kiuchi Masahide Yanagi Takao Nakamura
author_facet	Yoshiaki Kiuchi Masahide Yanagi Takao Nakamura
author_sort	Yoshiaki Kiuchi
title	Efficacy of amniotic membrane-assisted bleb revision for elevated intraocular pressure after filtering surgery
title_short	Efficacy of amniotic membrane-assisted bleb revision for elevated intraocular pressure after filtering surgery
title_full	Efficacy of amniotic membrane-assisted bleb revision for elevated intraocular pressure after filtering surgery
title_fullStr	Efficacy of amniotic membrane-assisted bleb revision for elevated intraocular pressure after filtering surgery
title_full_unstemmed	Efficacy of amniotic membrane-assisted bleb revision for elevated intraocular pressure after filtering surgery
title_sort	efficacy of amniotic membrane-assisted bleb revision for elevated intraocular pressure after filtering surgery
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/835f9f93345646108586573a868b7bcd
work_keys_str_mv	AT yoshiakikiuchi efficacyofamnioticmembraneassistedblebrevisionforelevatedintraocularpressureafterfilteringsurgery AT masahideyanagi efficacyofamnioticmembraneassistedblebrevisionforelevatedintraocularpressureafterfilteringsurgery AT takaonakamura efficacyofamnioticmembraneassistedblebrevisionforelevatedintraocularpressureafterfilteringsurgery
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Efficacy of amniotic membrane-assisted bleb revision for elevated intraocular pressure after filtering surgery

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