Acceptability of Carraguard vaginal microbicide gel among HIV-infected women in Chiang Rai, Thailand.

<h4>Background</h4>Few studies of microbicide acceptability among HIV-infected women have been done. We assessed Carraguard® vaginal gel acceptability among participants in a randomized, controlled, crossover safety trial in HIV-infected women in Thailand.<h4>Methodology/principal...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sara J Whitehead, Catherine McLean, Supaporn Chaikummao, Sarah Braunstein, Wat Utaivoravit, Janneke H van de Wijgert, Philip A Mock, Taweesap Siraprapasiri, Barbara A Friedland, Peter H Kilmarx, Lauri E Markowitz
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/836193a7f99d4bc1893ca8f4da864d31
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:836193a7f99d4bc1893ca8f4da864d31
record_format	dspace
spelling	oai:doaj.org-article:836193a7f99d4bc1893ca8f4da864d312021-11-18T06:46:36ZAcceptability of Carraguard vaginal microbicide gel among HIV-infected women in Chiang Rai, Thailand.1932-620310.1371/journal.pone.0014831https://doaj.org/article/836193a7f99d4bc1893ca8f4da864d312011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21915249/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Few studies of microbicide acceptability among HIV-infected women have been done. We assessed Carraguard® vaginal gel acceptability among participants in a randomized, controlled, crossover safety trial in HIV-infected women in Thailand.<h4>Methodology/principal findings</h4>Participants used each of 3 treatments (Carraguard gel, methylcellulose placebo gel, and no product) for 7 days, were randomized to one of six treatment sequences, and were blinded to the type of gel they received in the two gel-use periods. After both gel-use periods, acceptability was assessed by face-to-face interview. Responses were compared to those of women participating in two previous Carraguard safety studies at the same study site. Sixty women enrolled with a median age of 34 years; 25% were sexually active. Self-reported adherence (98%) and overall satisfaction rating of the gels (87% liked "somewhat" or "very much") were high, and most (77%) considered the volume of gel "just right." For most characteristics, crossover trial participants evaluated the gels more favorably than women in the other two trials, but there were few differences in the desired characteristics of a hypothetical microbicide. Almost half (48%) of crossover trial participants noticed a difference between Carraguard and placebo gels; 33% preferred Carraguard while 12% preferred placebo (p = 0.01).<h4>Conclusions/significance</h4>Daily Carraguard vaginal gel use was highly acceptable in this population of HIV-infected women, who assessed the gels more positively than women in two other trials at the site. This may be attributable to higher perceived need for protection among HIV-infected women, as well as to study design differences. This trial was registered in the U.S. National Institutes of Health clinical trials registry under registration number NCT00213044.Sara J WhiteheadCatherine McLeanSupaporn ChaikummaoSarah BraunsteinWat UtaivoravitJanneke H van de WijgertPhilip A MockTaweesap SiraprapasiriBarbara A FriedlandPeter H KilmarxLauri E MarkowitzPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 9, p e14831 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sara J Whitehead Catherine McLean Supaporn Chaikummao Sarah Braunstein Wat Utaivoravit Janneke H van de Wijgert Philip A Mock Taweesap Siraprapasiri Barbara A Friedland Peter H Kilmarx Lauri E Markowitz Acceptability of Carraguard vaginal microbicide gel among HIV-infected women in Chiang Rai, Thailand.
description	<h4>Background</h4>Few studies of microbicide acceptability among HIV-infected women have been done. We assessed Carraguard® vaginal gel acceptability among participants in a randomized, controlled, crossover safety trial in HIV-infected women in Thailand.<h4>Methodology/principal findings</h4>Participants used each of 3 treatments (Carraguard gel, methylcellulose placebo gel, and no product) for 7 days, were randomized to one of six treatment sequences, and were blinded to the type of gel they received in the two gel-use periods. After both gel-use periods, acceptability was assessed by face-to-face interview. Responses were compared to those of women participating in two previous Carraguard safety studies at the same study site. Sixty women enrolled with a median age of 34 years; 25% were sexually active. Self-reported adherence (98%) and overall satisfaction rating of the gels (87% liked "somewhat" or "very much") were high, and most (77%) considered the volume of gel "just right." For most characteristics, crossover trial participants evaluated the gels more favorably than women in the other two trials, but there were few differences in the desired characteristics of a hypothetical microbicide. Almost half (48%) of crossover trial participants noticed a difference between Carraguard and placebo gels; 33% preferred Carraguard while 12% preferred placebo (p = 0.01).<h4>Conclusions/significance</h4>Daily Carraguard vaginal gel use was highly acceptable in this population of HIV-infected women, who assessed the gels more positively than women in two other trials at the site. This may be attributable to higher perceived need for protection among HIV-infected women, as well as to study design differences. This trial was registered in the U.S. National Institutes of Health clinical trials registry under registration number NCT00213044.
format	article
author	Sara J Whitehead Catherine McLean Supaporn Chaikummao Sarah Braunstein Wat Utaivoravit Janneke H van de Wijgert Philip A Mock Taweesap Siraprapasiri Barbara A Friedland Peter H Kilmarx Lauri E Markowitz
author_facet	Sara J Whitehead Catherine McLean Supaporn Chaikummao Sarah Braunstein Wat Utaivoravit Janneke H van de Wijgert Philip A Mock Taweesap Siraprapasiri Barbara A Friedland Peter H Kilmarx Lauri E Markowitz
author_sort	Sara J Whitehead
title	Acceptability of Carraguard vaginal microbicide gel among HIV-infected women in Chiang Rai, Thailand.
title_short	Acceptability of Carraguard vaginal microbicide gel among HIV-infected women in Chiang Rai, Thailand.
title_full	Acceptability of Carraguard vaginal microbicide gel among HIV-infected women in Chiang Rai, Thailand.
title_fullStr	Acceptability of Carraguard vaginal microbicide gel among HIV-infected women in Chiang Rai, Thailand.
title_full_unstemmed	Acceptability of Carraguard vaginal microbicide gel among HIV-infected women in Chiang Rai, Thailand.
title_sort	acceptability of carraguard vaginal microbicide gel among hiv-infected women in chiang rai, thailand.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/836193a7f99d4bc1893ca8f4da864d31
work_keys_str_mv	AT sarajwhitehead acceptabilityofcarraguardvaginalmicrobicidegelamonghivinfectedwomeninchiangraithailand AT catherinemclean acceptabilityofcarraguardvaginalmicrobicidegelamonghivinfectedwomeninchiangraithailand AT supapornchaikummao acceptabilityofcarraguardvaginalmicrobicidegelamonghivinfectedwomeninchiangraithailand AT sarahbraunstein acceptabilityofcarraguardvaginalmicrobicidegelamonghivinfectedwomeninchiangraithailand AT watutaivoravit acceptabilityofcarraguardvaginalmicrobicidegelamonghivinfectedwomeninchiangraithailand AT jannekehvandewijgert acceptabilityofcarraguardvaginalmicrobicidegelamonghivinfectedwomeninchiangraithailand AT philipamock acceptabilityofcarraguardvaginalmicrobicidegelamonghivinfectedwomeninchiangraithailand AT taweesapsiraprapasiri acceptabilityofcarraguardvaginalmicrobicidegelamonghivinfectedwomeninchiangraithailand AT barbaraafriedland acceptabilityofcarraguardvaginalmicrobicidegelamonghivinfectedwomeninchiangraithailand AT peterhkilmarx acceptabilityofcarraguardvaginalmicrobicidegelamonghivinfectedwomeninchiangraithailand AT lauriemarkowitz acceptabilityofcarraguardvaginalmicrobicidegelamonghivinfectedwomeninchiangraithailand
_version_	1718424426607804416

Acceptability of Carraguard vaginal microbicide gel among HIV-infected women in Chiang Rai, Thailand.

Ejemplares similares