CryoEM structure of the human SLC4A4 sodium-coupled acid-base transporter NBCe1

Na+-coupled acid-base membrane transport proteins regulate blood pressure, ion homeostasis and acid-base chemistry. Here the authors present the 3.9 Å resolution cryoEM structure of the sodium-bicarbonate cotransporter NBCe1 and characterize its ion coordination site and ion accessibility pathway wi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kevin W. Huynh, Jiansen Jiang, Natalia Abuladze, Kirill Tsirulnikov, Liyo Kao, Xuesi Shao, Debra Newman, Rustam Azimov, Alexander Pushkin, Z. Hong Zhou, Ira Kurtz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8364ae1d1dec4883ada874ff703311fb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8364ae1d1dec4883ada874ff703311fb
record_format	dspace
spelling	oai:doaj.org-article:8364ae1d1dec4883ada874ff703311fb2021-12-02T17:32:46ZCryoEM structure of the human SLC4A4 sodium-coupled acid-base transporter NBCe110.1038/s41467-018-03271-32041-1723https://doaj.org/article/8364ae1d1dec4883ada874ff703311fb2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03271-3https://doaj.org/toc/2041-1723Na+-coupled acid-base membrane transport proteins regulate blood pressure, ion homeostasis and acid-base chemistry. Here the authors present the 3.9 Å resolution cryoEM structure of the sodium-bicarbonate cotransporter NBCe1 and characterize its ion coordination site and ion accessibility pathway with mutagenesis experiments.Kevin W. HuynhJiansen JiangNatalia AbuladzeKirill TsirulnikovLiyo KaoXuesi ShaoDebra NewmanRustam AzimovAlexander PushkinZ. Hong ZhouIra KurtzNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kevin W. Huynh Jiansen Jiang Natalia Abuladze Kirill Tsirulnikov Liyo Kao Xuesi Shao Debra Newman Rustam Azimov Alexander Pushkin Z. Hong Zhou Ira Kurtz CryoEM structure of the human SLC4A4 sodium-coupled acid-base transporter NBCe1
description	Na+-coupled acid-base membrane transport proteins regulate blood pressure, ion homeostasis and acid-base chemistry. Here the authors present the 3.9 Å resolution cryoEM structure of the sodium-bicarbonate cotransporter NBCe1 and characterize its ion coordination site and ion accessibility pathway with mutagenesis experiments.
format	article
author	Kevin W. Huynh Jiansen Jiang Natalia Abuladze Kirill Tsirulnikov Liyo Kao Xuesi Shao Debra Newman Rustam Azimov Alexander Pushkin Z. Hong Zhou Ira Kurtz
author_facet	Kevin W. Huynh Jiansen Jiang Natalia Abuladze Kirill Tsirulnikov Liyo Kao Xuesi Shao Debra Newman Rustam Azimov Alexander Pushkin Z. Hong Zhou Ira Kurtz
author_sort	Kevin W. Huynh
title	CryoEM structure of the human SLC4A4 sodium-coupled acid-base transporter NBCe1
title_short	CryoEM structure of the human SLC4A4 sodium-coupled acid-base transporter NBCe1
title_full	CryoEM structure of the human SLC4A4 sodium-coupled acid-base transporter NBCe1
title_fullStr	CryoEM structure of the human SLC4A4 sodium-coupled acid-base transporter NBCe1
title_full_unstemmed	CryoEM structure of the human SLC4A4 sodium-coupled acid-base transporter NBCe1
title_sort	cryoem structure of the human slc4a4 sodium-coupled acid-base transporter nbce1
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8364ae1d1dec4883ada874ff703311fb
work_keys_str_mv	AT kevinwhuynh cryoemstructureofthehumanslc4a4sodiumcoupledacidbasetransporternbce1 AT jiansenjiang cryoemstructureofthehumanslc4a4sodiumcoupledacidbasetransporternbce1 AT nataliaabuladze cryoemstructureofthehumanslc4a4sodiumcoupledacidbasetransporternbce1 AT kirilltsirulnikov cryoemstructureofthehumanslc4a4sodiumcoupledacidbasetransporternbce1 AT liyokao cryoemstructureofthehumanslc4a4sodiumcoupledacidbasetransporternbce1 AT xuesishao cryoemstructureofthehumanslc4a4sodiumcoupledacidbasetransporternbce1 AT debranewman cryoemstructureofthehumanslc4a4sodiumcoupledacidbasetransporternbce1 AT rustamazimov cryoemstructureofthehumanslc4a4sodiumcoupledacidbasetransporternbce1 AT alexanderpushkin cryoemstructureofthehumanslc4a4sodiumcoupledacidbasetransporternbce1 AT zhongzhou cryoemstructureofthehumanslc4a4sodiumcoupledacidbasetransporternbce1 AT irakurtz cryoemstructureofthehumanslc4a4sodiumcoupledacidbasetransporternbce1
_version_	1718380199652884480

CryoEM structure of the human SLC4A4 sodium-coupled acid-base transporter NBCe1

Ejemplares similares