Nanoparticles Enable Efficient Delivery of Antimicrobial Peptides for the Treatment of Deep Infections

Antimicrobial peptides (AMPs) have emerged as promising alternatives of traditional antibiotics against drug-resistant bacteria owing to their broad-spectrum antimicrobial properties and low tendency to drug resistance. However, their therapeutic efficacy in vivo, especially for infections in deep o...

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Autores principales:	Yingxue Deng, Rui Huang, Songyin Huang, Menghua Xiong
Formato:	article
Lenguaje:	EN
Publicado:	Compuscript Ltd 2021
Materias:	antimicrobial peptides deep infections drug delivery nanoparticles Medicine R
Acceso en línea:	https://doaj.org/article/836a661eaf4347c683c567e0c872b395
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spelling	oai:doaj.org-article:836a661eaf4347c683c567e0c872b3952021-11-09T08:30:25ZNanoparticles Enable Efficient Delivery of Antimicrobial Peptides for the Treatment of Deep Infections2712-008210.15212/bioi-2021-0003https://doaj.org/article/836a661eaf4347c683c567e0c872b3952021-07-01T00:00:00Zhttps://www.ingentaconnect.com/contentone/cscript/bioi/2021/00000002/00000002/art00003https://doaj.org/toc/2712-0082Antimicrobial peptides (AMPs) have emerged as promising alternatives of traditional antibiotics against drug-resistant bacteria owing to their broad-spectrum antimicrobial properties and low tendency to drug resistance. However, their therapeutic efficacy in vivo, especially for infections in deep organs, is limited owing to their systemic toxicity and low bioavailability. Nanoparticles-based delivery systems offer a strategy to increase the therapeutic index of AMPs by preventing proteolysis, increasing the accumulation at infection sites, and reducing toxicity. Herein, we will discuss the current progress of using nanoparticles as delivery vehicles for AMPs for the treatment of deep infections.Yingxue DengRui HuangSongyin HuangMenghua XiongCompuscript Ltdarticleantimicrobial peptidesdeep infectionsdrug deliverynanoparticlesMedicineRENBIO Integration, Vol 2, Iss 2, Pp 50-56 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antimicrobial peptides deep infections drug delivery nanoparticles Medicine R
spellingShingle	antimicrobial peptides deep infections drug delivery nanoparticles Medicine R Yingxue Deng Rui Huang Songyin Huang Menghua Xiong Nanoparticles Enable Efficient Delivery of Antimicrobial Peptides for the Treatment of Deep Infections
description	Antimicrobial peptides (AMPs) have emerged as promising alternatives of traditional antibiotics against drug-resistant bacteria owing to their broad-spectrum antimicrobial properties and low tendency to drug resistance. However, their therapeutic efficacy in vivo, especially for infections in deep organs, is limited owing to their systemic toxicity and low bioavailability. Nanoparticles-based delivery systems offer a strategy to increase the therapeutic index of AMPs by preventing proteolysis, increasing the accumulation at infection sites, and reducing toxicity. Herein, we will discuss the current progress of using nanoparticles as delivery vehicles for AMPs for the treatment of deep infections.
format	article
author	Yingxue Deng Rui Huang Songyin Huang Menghua Xiong
author_facet	Yingxue Deng Rui Huang Songyin Huang Menghua Xiong
author_sort	Yingxue Deng
title	Nanoparticles Enable Efficient Delivery of Antimicrobial Peptides for the Treatment of Deep Infections
title_short	Nanoparticles Enable Efficient Delivery of Antimicrobial Peptides for the Treatment of Deep Infections
title_full	Nanoparticles Enable Efficient Delivery of Antimicrobial Peptides for the Treatment of Deep Infections
title_fullStr	Nanoparticles Enable Efficient Delivery of Antimicrobial Peptides for the Treatment of Deep Infections
title_full_unstemmed	Nanoparticles Enable Efficient Delivery of Antimicrobial Peptides for the Treatment of Deep Infections
title_sort	nanoparticles enable efficient delivery of antimicrobial peptides for the treatment of deep infections
publisher	Compuscript Ltd
publishDate	2021
url	https://doaj.org/article/836a661eaf4347c683c567e0c872b395
work_keys_str_mv	AT yingxuedeng nanoparticlesenableefficientdeliveryofantimicrobialpeptidesforthetreatmentofdeepinfections AT ruihuang nanoparticlesenableefficientdeliveryofantimicrobialpeptidesforthetreatmentofdeepinfections AT songyinhuang nanoparticlesenableefficientdeliveryofantimicrobialpeptidesforthetreatmentofdeepinfections AT menghuaxiong nanoparticlesenableefficientdeliveryofantimicrobialpeptidesforthetreatmentofdeepinfections
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Nanoparticles Enable Efficient Delivery of Antimicrobial Peptides for the Treatment of Deep Infections

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