SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages

Toll-like receptors engage TIR domain-containing adaptors to control proinflammatory gene expression in response to pathogens and tissue damage. Here the authors show that the non-TIR domain-containing transmembrane protein SCIMP is a previously unrecognized TLR adaptor expressed by macrophages.

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Autores principales:	Lin Luo, Nilesh J. Bokil, Adam A. Wall, Ronan Kapetanovic, Natalie M. Lansdaal, Faustine Marceline, Belinda J. Burgess, Samuel J. Tong, Zhong Guo, Kirill Alexandrov, Ian L. Ross, Margaret L. Hibbs, Jennifer L. Stow, Matthew J. Sweet
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/836a68fa90214766a1565bfa90175cad
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spelling	oai:doaj.org-article:836a68fa90214766a1565bfa90175cad2021-12-02T14:42:01ZSCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages10.1038/ncomms141332041-1723https://doaj.org/article/836a68fa90214766a1565bfa90175cad2017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14133https://doaj.org/toc/2041-1723Toll-like receptors engage TIR domain-containing adaptors to control proinflammatory gene expression in response to pathogens and tissue damage. Here the authors show that the non-TIR domain-containing transmembrane protein SCIMP is a previously unrecognized TLR adaptor expressed by macrophages.Lin LuoNilesh J. BokilAdam A. WallRonan KapetanovicNatalie M. LansdaalFaustine MarcelineBelinda J. BurgessSamuel J. TongZhong GuoKirill AlexandrovIan L. RossMargaret L. HibbsJennifer L. StowMatthew J. SweetNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lin Luo Nilesh J. Bokil Adam A. Wall Ronan Kapetanovic Natalie M. Lansdaal Faustine Marceline Belinda J. Burgess Samuel J. Tong Zhong Guo Kirill Alexandrov Ian L. Ross Margaret L. Hibbs Jennifer L. Stow Matthew J. Sweet SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages
description	Toll-like receptors engage TIR domain-containing adaptors to control proinflammatory gene expression in response to pathogens and tissue damage. Here the authors show that the non-TIR domain-containing transmembrane protein SCIMP is a previously unrecognized TLR adaptor expressed by macrophages.
format	article
author	Lin Luo Nilesh J. Bokil Adam A. Wall Ronan Kapetanovic Natalie M. Lansdaal Faustine Marceline Belinda J. Burgess Samuel J. Tong Zhong Guo Kirill Alexandrov Ian L. Ross Margaret L. Hibbs Jennifer L. Stow Matthew J. Sweet
author_facet	Lin Luo Nilesh J. Bokil Adam A. Wall Ronan Kapetanovic Natalie M. Lansdaal Faustine Marceline Belinda J. Burgess Samuel J. Tong Zhong Guo Kirill Alexandrov Ian L. Ross Margaret L. Hibbs Jennifer L. Stow Matthew J. Sweet
author_sort	Lin Luo
title	SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages
title_short	SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages
title_full	SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages
title_fullStr	SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages
title_full_unstemmed	SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages
title_sort	scimp is a transmembrane non-tir tlr adaptor that promotes proinflammatory cytokine production from macrophages
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/836a68fa90214766a1565bfa90175cad
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SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages

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