Deletion of 3p13-14 locus spanning FOXP1 to SHQ1 cooperates with PTEN loss in prostate oncogenesis

Although the locus at 3p13-14 is commonly deleted in prostate cancer, the identity of the potential driver genes is still unclear. Here, the authors, using a PTEN loss-driven prostate cancer mouse model, show that a multigenic FOXP1-SHQ1 deletion is a driver event with prognostic value.

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Autores principales:	Haley Hieronymus, Phillip J. Iaquinta, John Wongvipat, Anuradha Gopalan, Rajmohan Murali, Ninghui Mao, Brett S. Carver, Charles L. Sawyers
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/836ceacd80084e6394c47fe1007f64e2
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spelling	oai:doaj.org-article:836ceacd80084e6394c47fe1007f64e22021-12-02T17:06:25ZDeletion of 3p13-14 locus spanning FOXP1 to SHQ1 cooperates with PTEN loss in prostate oncogenesis10.1038/s41467-017-01198-92041-1723https://doaj.org/article/836ceacd80084e6394c47fe1007f64e22017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01198-9https://doaj.org/toc/2041-1723Although the locus at 3p13-14 is commonly deleted in prostate cancer, the identity of the potential driver genes is still unclear. Here, the authors, using a PTEN loss-driven prostate cancer mouse model, show that a multigenic FOXP1-SHQ1 deletion is a driver event with prognostic value.Haley HieronymusPhillip J. IaquintaJohn WongvipatAnuradha GopalanRajmohan MuraliNinghui MaoBrett S. CarverCharles L. SawyersNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Haley Hieronymus Phillip J. Iaquinta John Wongvipat Anuradha Gopalan Rajmohan Murali Ninghui Mao Brett S. Carver Charles L. Sawyers Deletion of 3p13-14 locus spanning FOXP1 to SHQ1 cooperates with PTEN loss in prostate oncogenesis
description	Although the locus at 3p13-14 is commonly deleted in prostate cancer, the identity of the potential driver genes is still unclear. Here, the authors, using a PTEN loss-driven prostate cancer mouse model, show that a multigenic FOXP1-SHQ1 deletion is a driver event with prognostic value.
format	article
author	Haley Hieronymus Phillip J. Iaquinta John Wongvipat Anuradha Gopalan Rajmohan Murali Ninghui Mao Brett S. Carver Charles L. Sawyers
author_facet	Haley Hieronymus Phillip J. Iaquinta John Wongvipat Anuradha Gopalan Rajmohan Murali Ninghui Mao Brett S. Carver Charles L. Sawyers
author_sort	Haley Hieronymus
title	Deletion of 3p13-14 locus spanning FOXP1 to SHQ1 cooperates with PTEN loss in prostate oncogenesis
title_short	Deletion of 3p13-14 locus spanning FOXP1 to SHQ1 cooperates with PTEN loss in prostate oncogenesis
title_full	Deletion of 3p13-14 locus spanning FOXP1 to SHQ1 cooperates with PTEN loss in prostate oncogenesis
title_fullStr	Deletion of 3p13-14 locus spanning FOXP1 to SHQ1 cooperates with PTEN loss in prostate oncogenesis
title_full_unstemmed	Deletion of 3p13-14 locus spanning FOXP1 to SHQ1 cooperates with PTEN loss in prostate oncogenesis
title_sort	deletion of 3p13-14 locus spanning foxp1 to shq1 cooperates with pten loss in prostate oncogenesis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/836ceacd80084e6394c47fe1007f64e2
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Deletion of 3p13-14 locus spanning FOXP1 to SHQ1 cooperates with PTEN loss in prostate oncogenesis

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