Efficacy of anti-VEGF therapy combined with iontophoresis of Xueshuantong injection on retinal vein obstruction with macular edema

AIM: To study the clinical effects and safety of iontophoresis of xueshuantong injection combined with anti-vascular endothelial growth factor(VEGF)in the treatment of retinal vein occlusion(RVO)with macular edema(ME). METHODS: Totally 106 patients(106 eyes)with RVO and ME in the hospital between Ju...

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Autores principales:	Zi-Yue Xiang, Xiang-Xia Luo, Hong-Qiang Wang, Min Yang
Formato:	article
Lenguaje:	EN
Publicado:	Press of International Journal of Ophthalmology (IJO PRESS) 2021
Materias:	retinal vein occlusion macular edema conbercept xueshuantong iontophoresis Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/836d11944e054598b3542f3c05266db0
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spelling	oai:doaj.org-article:836d11944e054598b3542f3c05266db02021-11-22T14:22:33ZEfficacy of anti-VEGF therapy combined with iontophoresis of Xueshuantong injection on retinal vein obstruction with macular edema1672-512310.3980/j.issn.1672-5123.2021.12.25https://doaj.org/article/836d11944e054598b3542f3c05266db02021-12-01T00:00:00Zhttp://ies.ijo.cn/cn_publish/2021/12/202112025.pdfhttps://doaj.org/toc/1672-5123AIM: To study the clinical effects and safety of iontophoresis of xueshuantong injection combined with anti-vascular endothelial growth factor(VEGF)in the treatment of retinal vein occlusion(RVO)with macular edema(ME). METHODS: Totally 106 patients(106 eyes)with RVO and ME in the hospital between June 2017 and June 2019 were divided into observation group and control group according to the random number table method with 53 cases(53 eyes)in each group, and they were all given intravitreal injection of conbercept, and observation group was additionally given iontophoresis of Xueshuantong injection for intervention, and they were treated for 3mo. Both groups were followed up for 1a and given supplementary therapy according to the condition of the disease. The best corrected visual acuity(BCVA), central retinal thickness(CRT)in macular area, supplementary therapy status, VEGF level in aqueous humor and adverse drug reactions were observed and compared between the two groups before and after treatment. RESULTS: After treatment, the BCVA of the two groups was significantly improved(P<0.05)while the CRT in macular area was significantly thinned(P<0.05), and the BCVA on the 3, 6 and 12mo of treatment in observation group was better than that in control group while the CRT was thinner than that in control group(P<0.05). The macular volume and VEGF level in aqueous humor were significantly reduced in the two groups after treatment(P<0.05), and the macular volume and VEGF level on the 1, 3, 6 and 12mo of treatment in observation group were lower than those in control group(P<0.05). The injection frequencies of conbercept and triamcinolone acetonide and the proportion of patients with laser photocoagulation in observation group were lower than those in control group(P<0.05). During treatment, there was 1 eye of intraocular pressure increase and 3 eyes of subconjunctival hemorrhage in observation group, and there were 2 eyes of subconjunctival hemorrhage and 1 eye of endophthalmitis in control group(P>0.05).CONCLUSION: Xueshuantong iontophoresis combined with intravitreal injection of conbercept for RVO with ME can effectively inhibit the expression of VEGF, reduce the ME and improve the visual acuity of the affected eyes. The efficacy and safety are worthy of recognition.Zi-Yue XiangXiang-Xia LuoHong-Qiang WangMin YangPress of International Journal of Ophthalmology (IJO PRESS)articleretinal vein occlusionmacular edemaconberceptxueshuantongiontophoresisOphthalmologyRE1-994ENGuoji Yanke Zazhi, Vol 21, Iss 12, Pp 2150-2155 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	retinal vein occlusion macular edema conbercept xueshuantong iontophoresis Ophthalmology RE1-994
spellingShingle	retinal vein occlusion macular edema conbercept xueshuantong iontophoresis Ophthalmology RE1-994 Zi-Yue Xiang Xiang-Xia Luo Hong-Qiang Wang Min Yang Efficacy of anti-VEGF therapy combined with iontophoresis of Xueshuantong injection on retinal vein obstruction with macular edema
description	AIM: To study the clinical effects and safety of iontophoresis of xueshuantong injection combined with anti-vascular endothelial growth factor(VEGF)in the treatment of retinal vein occlusion(RVO)with macular edema(ME). METHODS: Totally 106 patients(106 eyes)with RVO and ME in the hospital between June 2017 and June 2019 were divided into observation group and control group according to the random number table method with 53 cases(53 eyes)in each group, and they were all given intravitreal injection of conbercept, and observation group was additionally given iontophoresis of Xueshuantong injection for intervention, and they were treated for 3mo. Both groups were followed up for 1a and given supplementary therapy according to the condition of the disease. The best corrected visual acuity(BCVA), central retinal thickness(CRT)in macular area, supplementary therapy status, VEGF level in aqueous humor and adverse drug reactions were observed and compared between the two groups before and after treatment. RESULTS: After treatment, the BCVA of the two groups was significantly improved(P<0.05)while the CRT in macular area was significantly thinned(P<0.05), and the BCVA on the 3, 6 and 12mo of treatment in observation group was better than that in control group while the CRT was thinner than that in control group(P<0.05). The macular volume and VEGF level in aqueous humor were significantly reduced in the two groups after treatment(P<0.05), and the macular volume and VEGF level on the 1, 3, 6 and 12mo of treatment in observation group were lower than those in control group(P<0.05). The injection frequencies of conbercept and triamcinolone acetonide and the proportion of patients with laser photocoagulation in observation group were lower than those in control group(P<0.05). During treatment, there was 1 eye of intraocular pressure increase and 3 eyes of subconjunctival hemorrhage in observation group, and there were 2 eyes of subconjunctival hemorrhage and 1 eye of endophthalmitis in control group(P>0.05).CONCLUSION: Xueshuantong iontophoresis combined with intravitreal injection of conbercept for RVO with ME can effectively inhibit the expression of VEGF, reduce the ME and improve the visual acuity of the affected eyes. The efficacy and safety are worthy of recognition.
format	article
author	Zi-Yue Xiang Xiang-Xia Luo Hong-Qiang Wang Min Yang
author_facet	Zi-Yue Xiang Xiang-Xia Luo Hong-Qiang Wang Min Yang
author_sort	Zi-Yue Xiang
title	Efficacy of anti-VEGF therapy combined with iontophoresis of Xueshuantong injection on retinal vein obstruction with macular edema
title_short	Efficacy of anti-VEGF therapy combined with iontophoresis of Xueshuantong injection on retinal vein obstruction with macular edema
title_full	Efficacy of anti-VEGF therapy combined with iontophoresis of Xueshuantong injection on retinal vein obstruction with macular edema
title_fullStr	Efficacy of anti-VEGF therapy combined with iontophoresis of Xueshuantong injection on retinal vein obstruction with macular edema
title_full_unstemmed	Efficacy of anti-VEGF therapy combined with iontophoresis of Xueshuantong injection on retinal vein obstruction with macular edema
title_sort	efficacy of anti-vegf therapy combined with iontophoresis of xueshuantong injection on retinal vein obstruction with macular edema
publisher	Press of International Journal of Ophthalmology (IJO PRESS)
publishDate	2021
url	https://doaj.org/article/836d11944e054598b3542f3c05266db0
work_keys_str_mv	AT ziyuexiang efficacyofantivegftherapycombinedwithiontophoresisofxueshuantonginjectiononretinalveinobstructionwithmacularedema AT xiangxialuo efficacyofantivegftherapycombinedwithiontophoresisofxueshuantonginjectiononretinalveinobstructionwithmacularedema AT hongqiangwang efficacyofantivegftherapycombinedwithiontophoresisofxueshuantonginjectiononretinalveinobstructionwithmacularedema AT minyang efficacyofantivegftherapycombinedwithiontophoresisofxueshuantonginjectiononretinalveinobstructionwithmacularedema
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Efficacy of anti-VEGF therapy combined with iontophoresis of Xueshuantong injection on retinal vein obstruction with macular edema

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