Functional and Clinical Significance of Dysregulated microRNAs in Liver Cancer

Liver cancer is the leading cause of cancer-related mortality in the world. This mainly reflects the lack of early diagnosis tools and effective treatment methods. MicroRNAs (miRNAs) are a class of non-transcribed RNAs, some of which play important regulatory roles in liver cancer. Here, we discuss...

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Autores principales:	Po-Shuan Huang, Chia-Jung Liao, Ya-Hui Huang, Chau-Ting Yeh, Cheng-Yi Chen, Hui-Chi Tang, Cheng-Chih Chang, Kwang-Huei Lin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	liver cancer microRNA clinical Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/8371ab7433bb469b9f39e1f908f787b1
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spelling	oai:doaj.org-article:8371ab7433bb469b9f39e1f908f787b12021-11-11T15:29:03ZFunctional and Clinical Significance of Dysregulated microRNAs in Liver Cancer10.3390/cancers132153612072-6694https://doaj.org/article/8371ab7433bb469b9f39e1f908f787b12021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5361https://doaj.org/toc/2072-6694Liver cancer is the leading cause of cancer-related mortality in the world. This mainly reflects the lack of early diagnosis tools and effective treatment methods. MicroRNAs (miRNAs) are a class of non-transcribed RNAs, some of which play important regulatory roles in liver cancer. Here, we discuss microRNAs with key impacts on liver cancer, such as miR-122, miR-21, miR-214, and miR-199. These microRNAs participate in various physiological regulatory pathways of liver cancer cells, and their modulation can have non-negligible effects in the treatment of liver cancer. We discuss whether these microRNAs can be used for better clinical diagnosis and/or drug development. With the advent of novel technologies, fast, inexpensive, and non-invasive RNA-based biomarker research has become a new mainstream approach. However, the clinical application of microRNA-based markers has been limited by the high sequence similarity among them and the potential for off-target problems. Therefore, researchers particularly value microRNAs that are specific to or have special functions in liver cancer. These include miR-122, which is specifically expressed in the liver, and miR-34, which is necessary for the replication of the hepatitis C virus in liver cancer. Clinical treatment drugs have been developed based on miR-34 and miR-122 (MRX34 and Miravirsen, respectively), but their side effects have not yet been overcome. Future research is needed to address these weaknesses and establish a feasible microRNA-based treatment strategy for liver cancer.Po-Shuan HuangChia-Jung LiaoYa-Hui HuangChau-Ting YehCheng-Yi ChenHui-Chi TangCheng-Chih ChangKwang-Huei LinMDPI AGarticleliver cancermicroRNAclinicalNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5361, p 5361 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	liver cancer microRNA clinical Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	liver cancer microRNA clinical Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Po-Shuan Huang Chia-Jung Liao Ya-Hui Huang Chau-Ting Yeh Cheng-Yi Chen Hui-Chi Tang Cheng-Chih Chang Kwang-Huei Lin Functional and Clinical Significance of Dysregulated microRNAs in Liver Cancer
description	Liver cancer is the leading cause of cancer-related mortality in the world. This mainly reflects the lack of early diagnosis tools and effective treatment methods. MicroRNAs (miRNAs) are a class of non-transcribed RNAs, some of which play important regulatory roles in liver cancer. Here, we discuss microRNAs with key impacts on liver cancer, such as miR-122, miR-21, miR-214, and miR-199. These microRNAs participate in various physiological regulatory pathways of liver cancer cells, and their modulation can have non-negligible effects in the treatment of liver cancer. We discuss whether these microRNAs can be used for better clinical diagnosis and/or drug development. With the advent of novel technologies, fast, inexpensive, and non-invasive RNA-based biomarker research has become a new mainstream approach. However, the clinical application of microRNA-based markers has been limited by the high sequence similarity among them and the potential for off-target problems. Therefore, researchers particularly value microRNAs that are specific to or have special functions in liver cancer. These include miR-122, which is specifically expressed in the liver, and miR-34, which is necessary for the replication of the hepatitis C virus in liver cancer. Clinical treatment drugs have been developed based on miR-34 and miR-122 (MRX34 and Miravirsen, respectively), but their side effects have not yet been overcome. Future research is needed to address these weaknesses and establish a feasible microRNA-based treatment strategy for liver cancer.
format	article
author	Po-Shuan Huang Chia-Jung Liao Ya-Hui Huang Chau-Ting Yeh Cheng-Yi Chen Hui-Chi Tang Cheng-Chih Chang Kwang-Huei Lin
author_facet	Po-Shuan Huang Chia-Jung Liao Ya-Hui Huang Chau-Ting Yeh Cheng-Yi Chen Hui-Chi Tang Cheng-Chih Chang Kwang-Huei Lin
author_sort	Po-Shuan Huang
title	Functional and Clinical Significance of Dysregulated microRNAs in Liver Cancer
title_short	Functional and Clinical Significance of Dysregulated microRNAs in Liver Cancer
title_full	Functional and Clinical Significance of Dysregulated microRNAs in Liver Cancer
title_fullStr	Functional and Clinical Significance of Dysregulated microRNAs in Liver Cancer
title_full_unstemmed	Functional and Clinical Significance of Dysregulated microRNAs in Liver Cancer
title_sort	functional and clinical significance of dysregulated micrornas in liver cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8371ab7433bb469b9f39e1f908f787b1
work_keys_str_mv	AT poshuanhuang functionalandclinicalsignificanceofdysregulatedmicrornasinlivercancer AT chiajungliao functionalandclinicalsignificanceofdysregulatedmicrornasinlivercancer AT yahuihuang functionalandclinicalsignificanceofdysregulatedmicrornasinlivercancer AT chautingyeh functionalandclinicalsignificanceofdysregulatedmicrornasinlivercancer AT chengyichen functionalandclinicalsignificanceofdysregulatedmicrornasinlivercancer AT huichitang functionalandclinicalsignificanceofdysregulatedmicrornasinlivercancer AT chengchihchang functionalandclinicalsignificanceofdysregulatedmicrornasinlivercancer AT kwanghueilin functionalandclinicalsignificanceofdysregulatedmicrornasinlivercancer
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Functional and Clinical Significance of Dysregulated microRNAs in Liver Cancer

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