Human genome-wide measurement of drug-responsive regulatory activity

Quantification of genomic responses to environmental stimuli by current genome-scale assays is limited to indirect measurements or requires knowledge of the transcription factors involved. Here, the authors use genome-wide high-throughput reporter assays to agnostically map enhancer activity in resp...

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Autores principales:	Graham D. Johnson, Alejandro Barrera, Ian C. McDowell, Anthony M. D’Ippolito, William H. Majoros, Christopher M. Vockley, Xingyan Wang, Andrew S. Allen, Timothy E. Reddy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/837311a1c18142aab64920fc7e8ddb75
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spelling	oai:doaj.org-article:837311a1c18142aab64920fc7e8ddb752021-12-02T17:32:15ZHuman genome-wide measurement of drug-responsive regulatory activity10.1038/s41467-018-07607-x2041-1723https://doaj.org/article/837311a1c18142aab64920fc7e8ddb752018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07607-xhttps://doaj.org/toc/2041-1723Quantification of genomic responses to environmental stimuli by current genome-scale assays is limited to indirect measurements or requires knowledge of the transcription factors involved. Here, the authors use genome-wide high-throughput reporter assays to agnostically map enhancer activity in response to glucocorticoid treatment across the human genome.Graham D. JohnsonAlejandro BarreraIan C. McDowellAnthony M. D’IppolitoWilliam H. MajorosChristopher M. VockleyXingyan WangAndrew S. AllenTimothy E. ReddyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Graham D. Johnson Alejandro Barrera Ian C. McDowell Anthony M. D’Ippolito William H. Majoros Christopher M. Vockley Xingyan Wang Andrew S. Allen Timothy E. Reddy Human genome-wide measurement of drug-responsive regulatory activity
description	Quantification of genomic responses to environmental stimuli by current genome-scale assays is limited to indirect measurements or requires knowledge of the transcription factors involved. Here, the authors use genome-wide high-throughput reporter assays to agnostically map enhancer activity in response to glucocorticoid treatment across the human genome.
format	article
author	Graham D. Johnson Alejandro Barrera Ian C. McDowell Anthony M. D’Ippolito William H. Majoros Christopher M. Vockley Xingyan Wang Andrew S. Allen Timothy E. Reddy
author_facet	Graham D. Johnson Alejandro Barrera Ian C. McDowell Anthony M. D’Ippolito William H. Majoros Christopher M. Vockley Xingyan Wang Andrew S. Allen Timothy E. Reddy
author_sort	Graham D. Johnson
title	Human genome-wide measurement of drug-responsive regulatory activity
title_short	Human genome-wide measurement of drug-responsive regulatory activity
title_full	Human genome-wide measurement of drug-responsive regulatory activity
title_fullStr	Human genome-wide measurement of drug-responsive regulatory activity
title_full_unstemmed	Human genome-wide measurement of drug-responsive regulatory activity
title_sort	human genome-wide measurement of drug-responsive regulatory activity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/837311a1c18142aab64920fc7e8ddb75
work_keys_str_mv	AT grahamdjohnson humangenomewidemeasurementofdrugresponsiveregulatoryactivity AT alejandrobarrera humangenomewidemeasurementofdrugresponsiveregulatoryactivity AT iancmcdowell humangenomewidemeasurementofdrugresponsiveregulatoryactivity AT anthonymdippolito humangenomewidemeasurementofdrugresponsiveregulatoryactivity AT williamhmajoros humangenomewidemeasurementofdrugresponsiveregulatoryactivity AT christophermvockley humangenomewidemeasurementofdrugresponsiveregulatoryactivity AT xingyanwang humangenomewidemeasurementofdrugresponsiveregulatoryactivity AT andrewsallen humangenomewidemeasurementofdrugresponsiveregulatoryactivity AT timothyereddy humangenomewidemeasurementofdrugresponsiveregulatoryactivity
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Human genome-wide measurement of drug-responsive regulatory activity

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