Experimental Approaches for Fertility Preservation in Prepubertal Boys Undergoing Oncological Therapy

Abstract An increasing number of prepubertal boys encountering infertility due to cancer treatment has prompted a range of studies to set up new methods for fertility restoration and male germ cell maturation. In this regard, cryopreservation of immature testicular tissue (ITT) from biopsy sample...

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Autor principal:	Keykavos Gholami
Formato:	article
Lenguaje:	EN
Publicado:	Urology Research Center 2020
Materias:	fertility preservation transplantation cancer germ cell maturation Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/8373769a4e734ed1a18fdb660a1fa03b
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spelling	oai:doaj.org-article:8373769a4e734ed1a18fdb660a1fa03b2021-11-30T05:23:49ZExperimental Approaches for Fertility Preservation in Prepubertal Boys Undergoing Oncological Therapy10.22034/TRU.2020.259243.10542717-042Xhttps://doaj.org/article/8373769a4e734ed1a18fdb660a1fa03b2020-11-01T00:00:00Zhttps://www.transresurology.com/article_119967.htmlhttps://doaj.org/toc/2717-042XAbstract An increasing number of prepubertal boys encountering infertility due to cancer treatment has prompted a range of studies to set up new methods for fertility restoration and male germ cell maturation. In this regard, cryopreservation of immature testicular tissue (ITT) from biopsy samples is being progressively advised in infertility centers. Different strategies to in vivo or in vitro male germ cell development using stored testicular tissues have been followed: autotransplantation or Xenotransplantation of testicular tissue pieces, spermatogonial stem cells (SSCs) isolation, and transplantation, in vitro spermatogenesis using three-dimensional (3D) culture and tissue culture. Combination of these strategies with assisted reproductive techniques (ART) like intracytoplasmic sperm injection (ICSI) and in vitro fertilization (IVF) has resulted from complete spermatogenesis resulting in offspring in several animal models but no achievement in producing mature spermatozoa from human prepubertal SSCs has yet been reported. This review describes studies done by researchers making effort on fertility restoration from ITT containing SSCs, Considering the limitations and specific concerns of each strategy.Keykavos Gholami Urology Research Centerarticlefertility preservationtransplantationcancergerm cell maturationDiseases of the genitourinary system. UrologyRC870-923ENTranslational Research in Urology, Vol 2, Iss 4, Pp 123-126 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	fertility preservation transplantation cancer germ cell maturation Diseases of the genitourinary system. Urology RC870-923
spellingShingle	fertility preservation transplantation cancer germ cell maturation Diseases of the genitourinary system. Urology RC870-923 Keykavos Gholami Experimental Approaches for Fertility Preservation in Prepubertal Boys Undergoing Oncological Therapy
description	Abstract An increasing number of prepubertal boys encountering infertility due to cancer treatment has prompted a range of studies to set up new methods for fertility restoration and male germ cell maturation. In this regard, cryopreservation of immature testicular tissue (ITT) from biopsy samples is being progressively advised in infertility centers. Different strategies to in vivo or in vitro male germ cell development using stored testicular tissues have been followed: autotransplantation or Xenotransplantation of testicular tissue pieces, spermatogonial stem cells (SSCs) isolation, and transplantation, in vitro spermatogenesis using three-dimensional (3D) culture and tissue culture. Combination of these strategies with assisted reproductive techniques (ART) like intracytoplasmic sperm injection (ICSI) and in vitro fertilization (IVF) has resulted from complete spermatogenesis resulting in offspring in several animal models but no achievement in producing mature spermatozoa from human prepubertal SSCs has yet been reported. This review describes studies done by researchers making effort on fertility restoration from ITT containing SSCs, Considering the limitations and specific concerns of each strategy.
format	article
author	Keykavos Gholami
author_facet	Keykavos Gholami
author_sort	Keykavos Gholami
title	Experimental Approaches for Fertility Preservation in Prepubertal Boys Undergoing Oncological Therapy
title_short	Experimental Approaches for Fertility Preservation in Prepubertal Boys Undergoing Oncological Therapy
title_full	Experimental Approaches for Fertility Preservation in Prepubertal Boys Undergoing Oncological Therapy
title_fullStr	Experimental Approaches for Fertility Preservation in Prepubertal Boys Undergoing Oncological Therapy
title_full_unstemmed	Experimental Approaches for Fertility Preservation in Prepubertal Boys Undergoing Oncological Therapy
title_sort	experimental approaches for fertility preservation in prepubertal boys undergoing oncological therapy
publisher	Urology Research Center
publishDate	2020
url	https://doaj.org/article/8373769a4e734ed1a18fdb660a1fa03b
work_keys_str_mv	AT keykavosgholami experimentalapproachesforfertilitypreservationinprepubertalboysundergoingoncologicaltherapy
_version_	1718406759163363328

Experimental Approaches for Fertility Preservation in Prepubertal Boys Undergoing Oncological Therapy

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