Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities

Phox homology (PX) domains are membrane interacting domains that bind to various lipids. Here authors screen all human PX domains systematically for their phospholipid preferences and define four classes and provide the basis for defining and predicting functional PX-membrane interactions.

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Autores principales: Mintu Chandra, Yanni K.-Y. Chin, Caroline Mas, J. Ryan Feathers, Blessy Paul, Sanchari Datta, Kai-En Chen, Xinying Jia, Zhe Yang, Suzanne J. Norwood, Biswaranjan Mohanty, Andrea Bugarcic, Rohan D. Teasdale, W. Mike Henne, Mehdi Mobli, Brett M. Collins
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/837519800813434db7bd127742edba4b
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spelling oai:doaj.org-article:837519800813434db7bd127742edba4b2021-12-02T17:01:59ZClassification of the human phox homology (PX) domains based on their phosphoinositide binding specificities10.1038/s41467-019-09355-y2041-1723https://doaj.org/article/837519800813434db7bd127742edba4b2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09355-yhttps://doaj.org/toc/2041-1723Phox homology (PX) domains are membrane interacting domains that bind to various lipids. Here authors screen all human PX domains systematically for their phospholipid preferences and define four classes and provide the basis for defining and predicting functional PX-membrane interactions.Mintu ChandraYanni K.-Y. ChinCaroline MasJ. Ryan FeathersBlessy PaulSanchari DattaKai-En ChenXinying JiaZhe YangSuzanne J. NorwoodBiswaranjan MohantyAndrea BugarcicRohan D. TeasdaleW. Mike HenneMehdi MobliBrett M. CollinsNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Mintu Chandra
Yanni K.-Y. Chin
Caroline Mas
J. Ryan Feathers
Blessy Paul
Sanchari Datta
Kai-En Chen
Xinying Jia
Zhe Yang
Suzanne J. Norwood
Biswaranjan Mohanty
Andrea Bugarcic
Rohan D. Teasdale
W. Mike Henne
Mehdi Mobli
Brett M. Collins
Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities
description Phox homology (PX) domains are membrane interacting domains that bind to various lipids. Here authors screen all human PX domains systematically for their phospholipid preferences and define four classes and provide the basis for defining and predicting functional PX-membrane interactions.
format article
author Mintu Chandra
Yanni K.-Y. Chin
Caroline Mas
J. Ryan Feathers
Blessy Paul
Sanchari Datta
Kai-En Chen
Xinying Jia
Zhe Yang
Suzanne J. Norwood
Biswaranjan Mohanty
Andrea Bugarcic
Rohan D. Teasdale
W. Mike Henne
Mehdi Mobli
Brett M. Collins
author_facet Mintu Chandra
Yanni K.-Y. Chin
Caroline Mas
J. Ryan Feathers
Blessy Paul
Sanchari Datta
Kai-En Chen
Xinying Jia
Zhe Yang
Suzanne J. Norwood
Biswaranjan Mohanty
Andrea Bugarcic
Rohan D. Teasdale
W. Mike Henne
Mehdi Mobli
Brett M. Collins
author_sort Mintu Chandra
title Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities
title_short Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities
title_full Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities
title_fullStr Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities
title_full_unstemmed Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities
title_sort classification of the human phox homology (px) domains based on their phosphoinositide binding specificities
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/837519800813434db7bd127742edba4b
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