Herbal formula YYJD inhibits tumor growth by inducing cell cycle arrest and senescence in lung cancer

Abstract Lung cancer represents a major cause of cancer-related death worldwide. Although various tactics and anti-tumor drugs have been used to improve curative effects, five-year survival rate of lung cancer patients remains poor. In this study, we investigated the action and underlying mechanisms...

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Autores principales:	Tingting Zheng, Zujun Que, Lijing Jiao, Yani Kang, Yabin Gong, Jialin Yao, Chao Ma, Ling Bi, Qihan Dong, Xiaodong Zhao, Ling Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8375b36f3fea48dabc0d060fde3e0a26
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spelling	oai:doaj.org-article:8375b36f3fea48dabc0d060fde3e0a262021-12-02T15:05:34ZHerbal formula YYJD inhibits tumor growth by inducing cell cycle arrest and senescence in lung cancer10.1038/s41598-017-05146-x2045-2322https://doaj.org/article/8375b36f3fea48dabc0d060fde3e0a262017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05146-xhttps://doaj.org/toc/2045-2322Abstract Lung cancer represents a major cause of cancer-related death worldwide. Although various tactics and anti-tumor drugs have been used to improve curative effects, five-year survival rate of lung cancer patients remains poor. In this study, we investigated the action and underlying mechanisms of our recently optimized Chinese herbal formula Yangyinjiedu (YYJD) against lung cancer. YYJD significantly inhibits the proliferation of lung cancer cell lines (95-D, A549, H460 and H1975) by inducing cell cycle arrest and senescence in a dose-dependent manner. In particular, YYJD induces significant G2/M phase arrest and inhibits the colony formation of lung cancer cells. Moreover, we found that administration of YYJD could inhibit the growth of xenografted lung cancer cells in nude mice without loss in body weight. Our findings suggest that the herbal formula YYJD is a potential anti-tumor agent against lung cancer.Tingting ZhengZujun QueLijing JiaoYani KangYabin GongJialin YaoChao MaLing BiQihan DongXiaodong ZhaoLing XuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tingting Zheng Zujun Que Lijing Jiao Yani Kang Yabin Gong Jialin Yao Chao Ma Ling Bi Qihan Dong Xiaodong Zhao Ling Xu Herbal formula YYJD inhibits tumor growth by inducing cell cycle arrest and senescence in lung cancer
description	Abstract Lung cancer represents a major cause of cancer-related death worldwide. Although various tactics and anti-tumor drugs have been used to improve curative effects, five-year survival rate of lung cancer patients remains poor. In this study, we investigated the action and underlying mechanisms of our recently optimized Chinese herbal formula Yangyinjiedu (YYJD) against lung cancer. YYJD significantly inhibits the proliferation of lung cancer cell lines (95-D, A549, H460 and H1975) by inducing cell cycle arrest and senescence in a dose-dependent manner. In particular, YYJD induces significant G2/M phase arrest and inhibits the colony formation of lung cancer cells. Moreover, we found that administration of YYJD could inhibit the growth of xenografted lung cancer cells in nude mice without loss in body weight. Our findings suggest that the herbal formula YYJD is a potential anti-tumor agent against lung cancer.
format	article
author	Tingting Zheng Zujun Que Lijing Jiao Yani Kang Yabin Gong Jialin Yao Chao Ma Ling Bi Qihan Dong Xiaodong Zhao Ling Xu
author_facet	Tingting Zheng Zujun Que Lijing Jiao Yani Kang Yabin Gong Jialin Yao Chao Ma Ling Bi Qihan Dong Xiaodong Zhao Ling Xu
author_sort	Tingting Zheng
title	Herbal formula YYJD inhibits tumor growth by inducing cell cycle arrest and senescence in lung cancer
title_short	Herbal formula YYJD inhibits tumor growth by inducing cell cycle arrest and senescence in lung cancer
title_full	Herbal formula YYJD inhibits tumor growth by inducing cell cycle arrest and senescence in lung cancer
title_fullStr	Herbal formula YYJD inhibits tumor growth by inducing cell cycle arrest and senescence in lung cancer
title_full_unstemmed	Herbal formula YYJD inhibits tumor growth by inducing cell cycle arrest and senescence in lung cancer
title_sort	herbal formula yyjd inhibits tumor growth by inducing cell cycle arrest and senescence in lung cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8375b36f3fea48dabc0d060fde3e0a26
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_version_	1718388776453013504

Herbal formula YYJD inhibits tumor growth by inducing cell cycle arrest and senescence in lung cancer

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