Output of a valveless Liebau pump with biologically relevant vessel properties and compression frequencies

Abstract Liebau pump is a tubular, non-peristaltic, pulsatile pump capable of creating unidirectional flow in the absence of valves. It requires asymmetrical positioning of the pincher relative to the attachment sites of its elastic segment to the rest of the circuit. Biological feasibility of such...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rubina Davtyan, Narine A. Sarvazyan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/837ac0b9d3694bba900ab7df8bd6027d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:837ac0b9d3694bba900ab7df8bd6027d
record_format	dspace
spelling	oai:doaj.org-article:837ac0b9d3694bba900ab7df8bd6027d2021-12-02T18:24:54ZOutput of a valveless Liebau pump with biologically relevant vessel properties and compression frequencies10.1038/s41598-021-90820-42045-2322https://doaj.org/article/837ac0b9d3694bba900ab7df8bd6027d2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90820-4https://doaj.org/toc/2045-2322Abstract Liebau pump is a tubular, non-peristaltic, pulsatile pump capable of creating unidirectional flow in the absence of valves. It requires asymmetrical positioning of the pincher relative to the attachment sites of its elastic segment to the rest of the circuit. Biological feasibility of such valveless pumps remains a hotly debated topic. To test the feasibility of the Liebau-based pumping in vessels with biologically relevant properties we quantified the output of Liebau pumps with their compliant segments made of a silicone rubber that mimicked the Young modulus of soft tissues. The lengths, the inner diameters, thicknesses of the tested compliant segments ranged from 1 to 5 cm, 3 to 8 mm and 0.3 to 1 mm, respectively. The compliant segment of the setup was compressed at 0.5–2.5 Hz frequencies using a 3.5-mm-wide rectangular piston. A nearest-neighbor tracking algorithm was used to track movements of 0.5-mm carbon particles within the system. The viscosity of the aqueous solution was varied by increased percentage of glycerin. Measurements yielded quantitative relationships between viscosity, frequency of compression and the net flowrate. The use of the Liebau principle of valveless pumping in conjunction with physiologically sized vessel and contraction frequencies yields flowrates comparable to peristaltic pumps of the same dimensions. We conclude that the data confirm physiological feasibility of Liebau-based pumping and warrant further testing of its mechanism using excised biological conduits or tissue engineered components. Such biomimetic pumps can serve as energy-efficient flow generators in microdevices or to study the function of embryonic heart during its normal development or in diseased states.Rubina DavtyanNarine A. SarvazyanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rubina Davtyan Narine A. Sarvazyan Output of a valveless Liebau pump with biologically relevant vessel properties and compression frequencies
description	Abstract Liebau pump is a tubular, non-peristaltic, pulsatile pump capable of creating unidirectional flow in the absence of valves. It requires asymmetrical positioning of the pincher relative to the attachment sites of its elastic segment to the rest of the circuit. Biological feasibility of such valveless pumps remains a hotly debated topic. To test the feasibility of the Liebau-based pumping in vessels with biologically relevant properties we quantified the output of Liebau pumps with their compliant segments made of a silicone rubber that mimicked the Young modulus of soft tissues. The lengths, the inner diameters, thicknesses of the tested compliant segments ranged from 1 to 5 cm, 3 to 8 mm and 0.3 to 1 mm, respectively. The compliant segment of the setup was compressed at 0.5–2.5 Hz frequencies using a 3.5-mm-wide rectangular piston. A nearest-neighbor tracking algorithm was used to track movements of 0.5-mm carbon particles within the system. The viscosity of the aqueous solution was varied by increased percentage of glycerin. Measurements yielded quantitative relationships between viscosity, frequency of compression and the net flowrate. The use of the Liebau principle of valveless pumping in conjunction with physiologically sized vessel and contraction frequencies yields flowrates comparable to peristaltic pumps of the same dimensions. We conclude that the data confirm physiological feasibility of Liebau-based pumping and warrant further testing of its mechanism using excised biological conduits or tissue engineered components. Such biomimetic pumps can serve as energy-efficient flow generators in microdevices or to study the function of embryonic heart during its normal development or in diseased states.
format	article
author	Rubina Davtyan Narine A. Sarvazyan
author_facet	Rubina Davtyan Narine A. Sarvazyan
author_sort	Rubina Davtyan
title	Output of a valveless Liebau pump with biologically relevant vessel properties and compression frequencies
title_short	Output of a valveless Liebau pump with biologically relevant vessel properties and compression frequencies
title_full	Output of a valveless Liebau pump with biologically relevant vessel properties and compression frequencies
title_fullStr	Output of a valveless Liebau pump with biologically relevant vessel properties and compression frequencies
title_full_unstemmed	Output of a valveless Liebau pump with biologically relevant vessel properties and compression frequencies
title_sort	output of a valveless liebau pump with biologically relevant vessel properties and compression frequencies
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/837ac0b9d3694bba900ab7df8bd6027d
work_keys_str_mv	AT rubinadavtyan outputofavalvelessliebaupumpwithbiologicallyrelevantvesselpropertiesandcompressionfrequencies AT narineasarvazyan outputofavalvelessliebaupumpwithbiologicallyrelevantvesselpropertiesandcompressionfrequencies
_version_	1718378105520783360

Output of a valveless Liebau pump with biologically relevant vessel properties and compression frequencies

Ejemplares similares