Clinical and Epidemiological Analysis of Children’s Urinary Tract Infections in Accordance with Antibiotic Resistance Patterns of Pathogens

The study was conducted to analyze urinary tract infections (UTI) in children by considering epidemiology and antibiotic resistance patterns of pathogens in accordance with inflammatory parameters. The research included 525 patients who demonstrated 627 episodes of UTI. The increasing resistance of...

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Autores principales:	Katarzyna Werbel, Dorota Jankowska, Anna Wasilewska, Katarzyna Taranta-Janusz
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	antibiotic resistance <i>Escherichia coli</i> inflammatory markers urinary tract infection Medicine R
Acceso en línea:	https://doaj.org/article/837afcf06b3b4a318b1aea824c4c674d
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spelling	oai:doaj.org-article:837afcf06b3b4a318b1aea824c4c674d2021-11-25T18:01:00ZClinical and Epidemiological Analysis of Children’s Urinary Tract Infections in Accordance with Antibiotic Resistance Patterns of Pathogens10.3390/jcm102252602077-0383https://doaj.org/article/837afcf06b3b4a318b1aea824c4c674d2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5260https://doaj.org/toc/2077-0383The study was conducted to analyze urinary tract infections (UTI) in children by considering epidemiology and antibiotic resistance patterns of pathogens in accordance with inflammatory parameters. The research included 525 patients who demonstrated 627 episodes of UTI. The increasing resistance of bacteria was observed over the years covered by the study (<i>p</i> < 0.001). There was a significant increase of resistance to amoxicillin with clavulanic acid (<i>p</i> = 0.001), gentamicin (<i>p</i> = 0.017) and ceftazidime (<i>p</i> = 0.0005). According to the CART method, we managed to estimate C-reactive protein (CRP), procalcitonin (PCT) and white blood cell (WBC) values, in which antibiotic sensitivity was observed. In children with CRP > 97.91 mg/L, there was a high percentage of sensitive cases to amoxicillin with clavulanic acid (87.5%). Values of WBC above 14.45 K/µL were associated with <i>E. coli</i> more sensitivity to ampicillin. 100% of children with CRP > 0.42 mg/L and PCT ≤ 6.92 ng/mL had confirmed sensitivity to cefuroxime. Concerning sensitivity to gentamicin, the most optimal cut-off point of WBC was >7.80 K/µL, while in the case of nitrofurantoin, it was CRP value > 0.11 mg/L (which was presented in 98.50% of children). These results may guide us with antibiotic therapy and help to inhibit increasing antibiotic resistance.Katarzyna WerbelDorota JankowskaAnna WasilewskaKatarzyna Taranta-JanuszMDPI AGarticleantibiotic resistance<i>Escherichia coli</i>inflammatory markersurinary tract infectionMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5260, p 5260 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antibiotic resistance <i>Escherichia coli</i> inflammatory markers urinary tract infection Medicine R
spellingShingle	antibiotic resistance <i>Escherichia coli</i> inflammatory markers urinary tract infection Medicine R Katarzyna Werbel Dorota Jankowska Anna Wasilewska Katarzyna Taranta-Janusz Clinical and Epidemiological Analysis of Children’s Urinary Tract Infections in Accordance with Antibiotic Resistance Patterns of Pathogens
description	The study was conducted to analyze urinary tract infections (UTI) in children by considering epidemiology and antibiotic resistance patterns of pathogens in accordance with inflammatory parameters. The research included 525 patients who demonstrated 627 episodes of UTI. The increasing resistance of bacteria was observed over the years covered by the study (<i>p</i> < 0.001). There was a significant increase of resistance to amoxicillin with clavulanic acid (<i>p</i> = 0.001), gentamicin (<i>p</i> = 0.017) and ceftazidime (<i>p</i> = 0.0005). According to the CART method, we managed to estimate C-reactive protein (CRP), procalcitonin (PCT) and white blood cell (WBC) values, in which antibiotic sensitivity was observed. In children with CRP > 97.91 mg/L, there was a high percentage of sensitive cases to amoxicillin with clavulanic acid (87.5%). Values of WBC above 14.45 K/µL were associated with <i>E. coli</i> more sensitivity to ampicillin. 100% of children with CRP > 0.42 mg/L and PCT ≤ 6.92 ng/mL had confirmed sensitivity to cefuroxime. Concerning sensitivity to gentamicin, the most optimal cut-off point of WBC was >7.80 K/µL, while in the case of nitrofurantoin, it was CRP value > 0.11 mg/L (which was presented in 98.50% of children). These results may guide us with antibiotic therapy and help to inhibit increasing antibiotic resistance.
format	article
author	Katarzyna Werbel Dorota Jankowska Anna Wasilewska Katarzyna Taranta-Janusz
author_facet	Katarzyna Werbel Dorota Jankowska Anna Wasilewska Katarzyna Taranta-Janusz
author_sort	Katarzyna Werbel
title	Clinical and Epidemiological Analysis of Children’s Urinary Tract Infections in Accordance with Antibiotic Resistance Patterns of Pathogens
title_short	Clinical and Epidemiological Analysis of Children’s Urinary Tract Infections in Accordance with Antibiotic Resistance Patterns of Pathogens
title_full	Clinical and Epidemiological Analysis of Children’s Urinary Tract Infections in Accordance with Antibiotic Resistance Patterns of Pathogens
title_fullStr	Clinical and Epidemiological Analysis of Children’s Urinary Tract Infections in Accordance with Antibiotic Resistance Patterns of Pathogens
title_full_unstemmed	Clinical and Epidemiological Analysis of Children’s Urinary Tract Infections in Accordance with Antibiotic Resistance Patterns of Pathogens
title_sort	clinical and epidemiological analysis of children’s urinary tract infections in accordance with antibiotic resistance patterns of pathogens
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/837afcf06b3b4a318b1aea824c4c674d
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_version_	1718411755511611392

Clinical and Epidemiological Analysis of Children’s Urinary Tract Infections in Accordance with Antibiotic Resistance Patterns of Pathogens

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