Trends in Non-invasive Prenatal Screening and Invasive Testing in Denmark (2000–2019) and Israel (2011–2019)

Introduction: Following the wide distribution of non-invasive prenatal genetic screening (NIPS), numerous studies have reported a decline in total invasive tests in the recent years, up to 50–70% in some countries. However, in Denmark and Israel we have not experienced these declines. The objective...

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Autores principales:	Lena Sagi-Dain, Amihood Singer, Olav B. Petersen, Stina Lou, Ida Vogel
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	chromosomal microarray analysis chromosome aberration prenatal testing non-invasive prenatal screening invasive testing Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/837d6e54c04e4c5eab9a6e01afad5d31
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spelling	oai:doaj.org-article:837d6e54c04e4c5eab9a6e01afad5d312021-11-17T05:26:15ZTrends in Non-invasive Prenatal Screening and Invasive Testing in Denmark (2000–2019) and Israel (2011–2019)2296-858X10.3389/fmed.2021.768997https://doaj.org/article/837d6e54c04e4c5eab9a6e01afad5d312021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.768997/fullhttps://doaj.org/toc/2296-858XIntroduction: Following the wide distribution of non-invasive prenatal genetic screening (NIPS), numerous studies have reported a decline in total invasive tests in the recent years, up to 50–70% in some countries. However, in Denmark and Israel we have not experienced these declines. The objective of our study was to evaluate the trends in NIPS and chromosomal microarray analysis (CMA) use in Denmark and Israel.Methods: This retrospective study was performed by data acquisition from the Danish Cytogenetics Central Registry throughout the years 2000–2019, and Israeli Public Health Services, Ministry of Health computerized database (from 2011).Results: Of the 1,243,956 live births registered in Denmark over the years 2000–2019, a relatively steady level of invasive testing around 6% was noted since 2004, as opposed to 13.0% in Israel based on 1,594,962 live births between 2011 and 2019. The average uptake of NIPS was 1.1 ± 0.5% in Denmark vs. 4.3% in Israel (2013–2019). Relatively steady rates of invasive testing were noted in both countries, compared to a slight decline in NIPS in the recent years.Discussion: The recent decrease in the rates of invasive testing in the NIPS era was not observed in Denmark or in Israel. These results imply that Danish and Israeli women and/or health providers might favor the high resolution and yield of CMA testing over the non-invasiveness of NIPS. We explore and discuss this phenomenon, based on five central factors.Lena Sagi-DainAmihood SingerOlav B. PetersenOlav B. PetersenStina LouIda VogelIda VogelFrontiers Media S.A.articlechromosomal microarray analysischromosome aberrationprenatal testingnon-invasive prenatal screeninginvasive testingMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chromosomal microarray analysis chromosome aberration prenatal testing non-invasive prenatal screening invasive testing Medicine (General) R5-920
spellingShingle	chromosomal microarray analysis chromosome aberration prenatal testing non-invasive prenatal screening invasive testing Medicine (General) R5-920 Lena Sagi-Dain Amihood Singer Olav B. Petersen Olav B. Petersen Stina Lou Ida Vogel Ida Vogel Trends in Non-invasive Prenatal Screening and Invasive Testing in Denmark (2000–2019) and Israel (2011–2019)
description	Introduction: Following the wide distribution of non-invasive prenatal genetic screening (NIPS), numerous studies have reported a decline in total invasive tests in the recent years, up to 50–70% in some countries. However, in Denmark and Israel we have not experienced these declines. The objective of our study was to evaluate the trends in NIPS and chromosomal microarray analysis (CMA) use in Denmark and Israel.Methods: This retrospective study was performed by data acquisition from the Danish Cytogenetics Central Registry throughout the years 2000–2019, and Israeli Public Health Services, Ministry of Health computerized database (from 2011).Results: Of the 1,243,956 live births registered in Denmark over the years 2000–2019, a relatively steady level of invasive testing around 6% was noted since 2004, as opposed to 13.0% in Israel based on 1,594,962 live births between 2011 and 2019. The average uptake of NIPS was 1.1 ± 0.5% in Denmark vs. 4.3% in Israel (2013–2019). Relatively steady rates of invasive testing were noted in both countries, compared to a slight decline in NIPS in the recent years.Discussion: The recent decrease in the rates of invasive testing in the NIPS era was not observed in Denmark or in Israel. These results imply that Danish and Israeli women and/or health providers might favor the high resolution and yield of CMA testing over the non-invasiveness of NIPS. We explore and discuss this phenomenon, based on five central factors.
format	article
author	Lena Sagi-Dain Amihood Singer Olav B. Petersen Olav B. Petersen Stina Lou Ida Vogel Ida Vogel
author_facet	Lena Sagi-Dain Amihood Singer Olav B. Petersen Olav B. Petersen Stina Lou Ida Vogel Ida Vogel
author_sort	Lena Sagi-Dain
title	Trends in Non-invasive Prenatal Screening and Invasive Testing in Denmark (2000–2019) and Israel (2011–2019)
title_short	Trends in Non-invasive Prenatal Screening and Invasive Testing in Denmark (2000–2019) and Israel (2011–2019)
title_full	Trends in Non-invasive Prenatal Screening and Invasive Testing in Denmark (2000–2019) and Israel (2011–2019)
title_fullStr	Trends in Non-invasive Prenatal Screening and Invasive Testing in Denmark (2000–2019) and Israel (2011–2019)
title_full_unstemmed	Trends in Non-invasive Prenatal Screening and Invasive Testing in Denmark (2000–2019) and Israel (2011–2019)
title_sort	trends in non-invasive prenatal screening and invasive testing in denmark (2000–2019) and israel (2011–2019)
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/837d6e54c04e4c5eab9a6e01afad5d31
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Trends in Non-invasive Prenatal Screening and Invasive Testing in Denmark (2000–2019) and Israel (2011–2019)

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