Primary central nervous system lymphomas express immunohistochemical factors of autophagy

Abstract Primary central nervous system lymphoma (PCNSL) is an aggressive and rare disease. Autophagy is a catabolic mechanism boosting various tumors, including lymphomas; its inhibition is thus a promising therapeutic target. Its presence has never been studied in PCNSLs. We conducted a retrospect...

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Autores principales:	Georgia Karpathiou, Silvia-Maria Babiuc, Florian Camy, Elise Ferrand, Alexandra Papoudou-Bai, Jean Marc Dumollard, Jerome Cornillon, Michel Peoc’h
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/837f0784766340ea88d282e1ac2346c4
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spelling	oai:doaj.org-article:837f0784766340ea88d282e1ac2346c42021-11-21T12:24:38ZPrimary central nervous system lymphomas express immunohistochemical factors of autophagy10.1038/s41598-021-01693-62045-2322https://doaj.org/article/837f0784766340ea88d282e1ac2346c42021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01693-6https://doaj.org/toc/2045-2322Abstract Primary central nervous system lymphoma (PCNSL) is an aggressive and rare disease. Autophagy is a catabolic mechanism boosting various tumors, including lymphomas; its inhibition is thus a promising therapeutic target. Its presence has never been studied in PCNSLs. We conducted a retrospective immunohistochemical study of 25 PCNSLs for LC3B, p62, and M6PR, comparing it with clinicopathological characteristics. Fourteen (56%) and eleven (44%) PCNSLs were of low and high LC3B expression, respectively. p62 expression was present in most tumors (n = 21, 84%). M6PR was present in all tumors, with 14 (56%) and 11 (44%) cases being of low and high M6PR expression, respectively. LC3B expression was correlated with the performance status (PS) (p = 0.04). No association was found with other clinical parameters, such as deep structure invasion, multiple lesions, complete response, and recurrence after response. p62 showed a strong positive association with MUM1 expression (p = 0.0005). M6PR expression showed a positive correlation (p = 0.04) with PD-L1 expression. No association was found with p53, Ki67, CD8, BCL2, BCL6, or double MYC/BLC2 co-expressors. No association of LC3B, p62, and M6PR expression with survival was found. Our findings provide evidence for the possible presence of autophagic markers in PCNSLs and, thus, for possible treatment targets.Georgia KarpathiouSilvia-Maria BabiucFlorian CamyElise FerrandAlexandra Papoudou-BaiJean Marc DumollardJerome CornillonMichel Peoc’hNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Georgia Karpathiou Silvia-Maria Babiuc Florian Camy Elise Ferrand Alexandra Papoudou-Bai Jean Marc Dumollard Jerome Cornillon Michel Peoc’h Primary central nervous system lymphomas express immunohistochemical factors of autophagy
description	Abstract Primary central nervous system lymphoma (PCNSL) is an aggressive and rare disease. Autophagy is a catabolic mechanism boosting various tumors, including lymphomas; its inhibition is thus a promising therapeutic target. Its presence has never been studied in PCNSLs. We conducted a retrospective immunohistochemical study of 25 PCNSLs for LC3B, p62, and M6PR, comparing it with clinicopathological characteristics. Fourteen (56%) and eleven (44%) PCNSLs were of low and high LC3B expression, respectively. p62 expression was present in most tumors (n = 21, 84%). M6PR was present in all tumors, with 14 (56%) and 11 (44%) cases being of low and high M6PR expression, respectively. LC3B expression was correlated with the performance status (PS) (p = 0.04). No association was found with other clinical parameters, such as deep structure invasion, multiple lesions, complete response, and recurrence after response. p62 showed a strong positive association with MUM1 expression (p = 0.0005). M6PR expression showed a positive correlation (p = 0.04) with PD-L1 expression. No association was found with p53, Ki67, CD8, BCL2, BCL6, or double MYC/BLC2 co-expressors. No association of LC3B, p62, and M6PR expression with survival was found. Our findings provide evidence for the possible presence of autophagic markers in PCNSLs and, thus, for possible treatment targets.
format	article
author	Georgia Karpathiou Silvia-Maria Babiuc Florian Camy Elise Ferrand Alexandra Papoudou-Bai Jean Marc Dumollard Jerome Cornillon Michel Peoc’h
author_facet	Georgia Karpathiou Silvia-Maria Babiuc Florian Camy Elise Ferrand Alexandra Papoudou-Bai Jean Marc Dumollard Jerome Cornillon Michel Peoc’h
author_sort	Georgia Karpathiou
title	Primary central nervous system lymphomas express immunohistochemical factors of autophagy
title_short	Primary central nervous system lymphomas express immunohistochemical factors of autophagy
title_full	Primary central nervous system lymphomas express immunohistochemical factors of autophagy
title_fullStr	Primary central nervous system lymphomas express immunohistochemical factors of autophagy
title_full_unstemmed	Primary central nervous system lymphomas express immunohistochemical factors of autophagy
title_sort	primary central nervous system lymphomas express immunohistochemical factors of autophagy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/837f0784766340ea88d282e1ac2346c4
work_keys_str_mv	AT georgiakarpathiou primarycentralnervoussystemlymphomasexpressimmunohistochemicalfactorsofautophagy AT silviamariababiuc primarycentralnervoussystemlymphomasexpressimmunohistochemicalfactorsofautophagy AT floriancamy primarycentralnervoussystemlymphomasexpressimmunohistochemicalfactorsofautophagy AT eliseferrand primarycentralnervoussystemlymphomasexpressimmunohistochemicalfactorsofautophagy AT alexandrapapoudoubai primarycentralnervoussystemlymphomasexpressimmunohistochemicalfactorsofautophagy AT jeanmarcdumollard primarycentralnervoussystemlymphomasexpressimmunohistochemicalfactorsofautophagy AT jeromecornillon primarycentralnervoussystemlymphomasexpressimmunohistochemicalfactorsofautophagy AT michelpeoch primarycentralnervoussystemlymphomasexpressimmunohistochemicalfactorsofautophagy
_version_	1718419017415262208

Primary central nervous system lymphomas express immunohistochemical factors of autophagy

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