Association of prealbumin levels with contrast-induced acute kidney injury in elderly patients with elective percutaneous coronary intervention

Zhe-Bin You,1,* Kai-Yang Lin,2,* Wei-Ping Zheng,1 Chun-Jin Lin,1 Fan Lin,1 Tai-Lin Guo,1 Peng-Li Zhu,1 Yan-Song Guo2 1Department of Geriatric Medicine, Fujian Provincial Hospital, Fujian Key Laboratory of Geriatrics, Fujian Provincial Center for Geriatrics, Fujian Medical University, Fuzhou, People...

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Autores principales:	You ZB, Lin KY, Zheng WP, Lin CJ, Lin F, Guo TL, Zhu PL, Guo YS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	prealbumin contrast-induced acute kidney injury percutaneous coronary intervention elderly Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/83828be6afe548efb776acea9b5ffa39
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spelling	oai:doaj.org-article:83828be6afe548efb776acea9b5ffa392021-12-02T00:11:50ZAssociation of prealbumin levels with contrast-induced acute kidney injury in elderly patients with elective percutaneous coronary intervention1178-1998https://doaj.org/article/83828be6afe548efb776acea9b5ffa392018-04-01T00:00:00Zhttps://www.dovepress.com/association-of-prealbumin-levels-with-contrast-induced-acute-kidney-in-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Zhe-Bin You,1,* Kai-Yang Lin,2,* Wei-Ping Zheng,1 Chun-Jin Lin,1 Fan Lin,1 Tai-Lin Guo,1 Peng-Li Zhu,1 Yan-Song Guo2 1Department of Geriatric Medicine, Fujian Provincial Hospital, Fujian Key Laboratory of Geriatrics, Fujian Provincial Center for Geriatrics, Fujian Medical University, Fuzhou, People’s Republic of China; 2Department of Cardiology, Fujian Provincial Hospital, Fujian Cardiovascular Institute, Fujian Medical University, Fuzhou, People’s Republic of China *These authors contributed equally to this work Purpose: Inflammatory factors play a critical role in contrast-induced acute kidney injury (CI-AKI). Prealbumin, a nutritional and inflammatory indicator, is a well-established predictor of short- and long-term outcomes in numerous clinical conditions. The current study investigated the association of pre-procedural prealbumin levels with CI-AKI and long-term outcomes in geriatric patients after elective percutaneous coronary intervention (PCI).Patients and methods: A total of 558 patients aged≥75 years, who underwent elective PCI between January 2012 and December 2015, were selected for the current study. Pre-procedural prealbumin levels were measured before PCI. Multivariable logistic regression and Cox proportional hazard regression analyses were performed to identify the independent risk factors for CI-AKI and long-term mortality.Results: Out of 558 patients, 54 developed CI-AKI. The optimal cutoff value of prealbumin for detecting CI-AKI was 185.5 mg/L with 62.7% sensitivity and 70.4% specificity based on the receiver operating characteristic analysis (C-statistic=0.710; 95% confidence interval [CI] 0.673–0.751). Multivariable analysis demonstrated that prealbumin≤185.5 mg/L was significantly associated with CI-AKI (odds ratio [OR] 0.397; 95% CI 0.195–0.808; P=0.011). Cox regression analysis demonstrated that prealbumin≤185.5 mg/L was associated with long-term mortality (adjusted hazard ratio [HR] 0.525; 95% CI 0.289–0.952; P=0.034) during the follow-up.Conclusion: Pre-procedural levels of prealbumin were independently associated with an increased risk of CI-AKI and long-term mortality in elderly patients undergoing elective PCI. Keywords: prealbumin, contrast-induced acute kidney injury, percutaneous coronary intervention, elderly You ZBLin KYZheng WPLin CJLin FGuo TLZhu PLGuo YSDove Medical Pressarticleprealbumincontrast-induced acute kidney injurypercutaneous coronary interventionelderlyGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 13, Pp 641-649 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	prealbumin contrast-induced acute kidney injury percutaneous coronary intervention elderly Geriatrics RC952-954.6
spellingShingle	prealbumin contrast-induced acute kidney injury percutaneous coronary intervention elderly Geriatrics RC952-954.6 You ZB Lin KY Zheng WP Lin CJ Lin F Guo TL Zhu PL Guo YS Association of prealbumin levels with contrast-induced acute kidney injury in elderly patients with elective percutaneous coronary intervention
description	Zhe-Bin You,1,* Kai-Yang Lin,2,* Wei-Ping Zheng,1 Chun-Jin Lin,1 Fan Lin,1 Tai-Lin Guo,1 Peng-Li Zhu,1 Yan-Song Guo2 1Department of Geriatric Medicine, Fujian Provincial Hospital, Fujian Key Laboratory of Geriatrics, Fujian Provincial Center for Geriatrics, Fujian Medical University, Fuzhou, People’s Republic of China; 2Department of Cardiology, Fujian Provincial Hospital, Fujian Cardiovascular Institute, Fujian Medical University, Fuzhou, People’s Republic of China *These authors contributed equally to this work Purpose: Inflammatory factors play a critical role in contrast-induced acute kidney injury (CI-AKI). Prealbumin, a nutritional and inflammatory indicator, is a well-established predictor of short- and long-term outcomes in numerous clinical conditions. The current study investigated the association of pre-procedural prealbumin levels with CI-AKI and long-term outcomes in geriatric patients after elective percutaneous coronary intervention (PCI).Patients and methods: A total of 558 patients aged≥75 years, who underwent elective PCI between January 2012 and December 2015, were selected for the current study. Pre-procedural prealbumin levels were measured before PCI. Multivariable logistic regression and Cox proportional hazard regression analyses were performed to identify the independent risk factors for CI-AKI and long-term mortality.Results: Out of 558 patients, 54 developed CI-AKI. The optimal cutoff value of prealbumin for detecting CI-AKI was 185.5 mg/L with 62.7% sensitivity and 70.4% specificity based on the receiver operating characteristic analysis (C-statistic=0.710; 95% confidence interval [CI] 0.673–0.751). Multivariable analysis demonstrated that prealbumin≤185.5 mg/L was significantly associated with CI-AKI (odds ratio [OR] 0.397; 95% CI 0.195–0.808; P=0.011). Cox regression analysis demonstrated that prealbumin≤185.5 mg/L was associated with long-term mortality (adjusted hazard ratio [HR] 0.525; 95% CI 0.289–0.952; P=0.034) during the follow-up.Conclusion: Pre-procedural levels of prealbumin were independently associated with an increased risk of CI-AKI and long-term mortality in elderly patients undergoing elective PCI. Keywords: prealbumin, contrast-induced acute kidney injury, percutaneous coronary intervention, elderly
format	article
author	You ZB Lin KY Zheng WP Lin CJ Lin F Guo TL Zhu PL Guo YS
author_facet	You ZB Lin KY Zheng WP Lin CJ Lin F Guo TL Zhu PL Guo YS
author_sort	You ZB
title	Association of prealbumin levels with contrast-induced acute kidney injury in elderly patients with elective percutaneous coronary intervention
title_short	Association of prealbumin levels with contrast-induced acute kidney injury in elderly patients with elective percutaneous coronary intervention
title_full	Association of prealbumin levels with contrast-induced acute kidney injury in elderly patients with elective percutaneous coronary intervention
title_fullStr	Association of prealbumin levels with contrast-induced acute kidney injury in elderly patients with elective percutaneous coronary intervention
title_full_unstemmed	Association of prealbumin levels with contrast-induced acute kidney injury in elderly patients with elective percutaneous coronary intervention
title_sort	association of prealbumin levels with contrast-induced acute kidney injury in elderly patients with elective percutaneous coronary intervention
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/83828be6afe548efb776acea9b5ffa39
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Association of prealbumin levels with contrast-induced acute kidney injury in elderly patients with elective percutaneous coronary intervention

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