Non-invasive plasma glycomic and metabolic biomarkers of post-treatment control of HIV

Current HIV cure-focused clinical trials rely on analytic treatment interruption (ATI) to evaluate post-treatment control (PTC). Here, combining untargetted metabolomics and glycomics in two HIV clinical cohorts, in vitro assays, and machine learning, the authors identify and validate metabolic and...

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Autores principales:	Leila B. Giron, Clovis S. Palmer, Qin Liu, Xiangfan Yin, Emmanouil Papasavvas, Radwa Sharaf, Behzad Etemad, Mohammad Damra, Aaron R. Goldman, Hsin-Yao Tang, Rowena Johnston, Karam Mounzer, Jay R. Kostman, Pablo Tebas, Alan Landay, Luis J. Montaner, Jeffrey M. Jacobson, Jonathan Z. Li, Mohamed Abdel-Mohsen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8389144aeb1a4d6d950f9fd144f01fe1
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spelling	oai:doaj.org-article:8389144aeb1a4d6d950f9fd144f01fe12021-12-02T18:18:35ZNon-invasive plasma glycomic and metabolic biomarkers of post-treatment control of HIV10.1038/s41467-021-24077-w2041-1723https://doaj.org/article/8389144aeb1a4d6d950f9fd144f01fe12021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24077-whttps://doaj.org/toc/2041-1723Current HIV cure-focused clinical trials rely on analytic treatment interruption (ATI) to evaluate post-treatment control (PTC). Here, combining untargetted metabolomics and glycomics in two HIV clinical cohorts, in vitro assays, and machine learning, the authors identify and validate metabolic and glycomic biomarkers linked to inflammatory pathways and HIV latency reactivation associated with PTC, suggesting non-invasive biomarkers as an alternative to predict HIV remission.Leila B. GironClovis S. PalmerQin LiuXiangfan YinEmmanouil PapasavvasRadwa SharafBehzad EtemadMohammad DamraAaron R. GoldmanHsin-Yao TangRowena JohnstonKaram MounzerJay R. KostmanPablo TebasAlan LandayLuis J. MontanerJeffrey M. JacobsonJonathan Z. LiMohamed Abdel-MohsenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Leila B. Giron Clovis S. Palmer Qin Liu Xiangfan Yin Emmanouil Papasavvas Radwa Sharaf Behzad Etemad Mohammad Damra Aaron R. Goldman Hsin-Yao Tang Rowena Johnston Karam Mounzer Jay R. Kostman Pablo Tebas Alan Landay Luis J. Montaner Jeffrey M. Jacobson Jonathan Z. Li Mohamed Abdel-Mohsen Non-invasive plasma glycomic and metabolic biomarkers of post-treatment control of HIV
description	Current HIV cure-focused clinical trials rely on analytic treatment interruption (ATI) to evaluate post-treatment control (PTC). Here, combining untargetted metabolomics and glycomics in two HIV clinical cohorts, in vitro assays, and machine learning, the authors identify and validate metabolic and glycomic biomarkers linked to inflammatory pathways and HIV latency reactivation associated with PTC, suggesting non-invasive biomarkers as an alternative to predict HIV remission.
format	article
author	Leila B. Giron Clovis S. Palmer Qin Liu Xiangfan Yin Emmanouil Papasavvas Radwa Sharaf Behzad Etemad Mohammad Damra Aaron R. Goldman Hsin-Yao Tang Rowena Johnston Karam Mounzer Jay R. Kostman Pablo Tebas Alan Landay Luis J. Montaner Jeffrey M. Jacobson Jonathan Z. Li Mohamed Abdel-Mohsen
author_facet	Leila B. Giron Clovis S. Palmer Qin Liu Xiangfan Yin Emmanouil Papasavvas Radwa Sharaf Behzad Etemad Mohammad Damra Aaron R. Goldman Hsin-Yao Tang Rowena Johnston Karam Mounzer Jay R. Kostman Pablo Tebas Alan Landay Luis J. Montaner Jeffrey M. Jacobson Jonathan Z. Li Mohamed Abdel-Mohsen
author_sort	Leila B. Giron
title	Non-invasive plasma glycomic and metabolic biomarkers of post-treatment control of HIV
title_short	Non-invasive plasma glycomic and metabolic biomarkers of post-treatment control of HIV
title_full	Non-invasive plasma glycomic and metabolic biomarkers of post-treatment control of HIV
title_fullStr	Non-invasive plasma glycomic and metabolic biomarkers of post-treatment control of HIV
title_full_unstemmed	Non-invasive plasma glycomic and metabolic biomarkers of post-treatment control of HIV
title_sort	non-invasive plasma glycomic and metabolic biomarkers of post-treatment control of hiv
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8389144aeb1a4d6d950f9fd144f01fe1
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Non-invasive plasma glycomic and metabolic biomarkers of post-treatment control of HIV

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