Chronopharmacology in Therapeutic Drug Monitoring—Dependencies between the Rhythmics of Pharmacokinetic Processes and Drug Concentration in Blood

The objective of the optimization of pharmacotherapy compliant with the basic rules of clinical pharmacology is its maximum individualization, ensuring paramount effectiveness and security of the patient’s therapy. Thus, multiple factors that are decisive in terms of uniqueness of treatment of the g...

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Autor principal:	Lukasz Dobrek
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	chronopharmacology circadian rhythm therapeutic drug monitoring chronopharmacokinetics Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/838a83b98d4f42dbabe419ba6ab7261e
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spelling	oai:doaj.org-article:838a83b98d4f42dbabe419ba6ab7261e2021-11-25T18:41:46ZChronopharmacology in Therapeutic Drug Monitoring—Dependencies between the Rhythmics of Pharmacokinetic Processes and Drug Concentration in Blood10.3390/pharmaceutics131119151999-4923https://doaj.org/article/838a83b98d4f42dbabe419ba6ab7261e2021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1915https://doaj.org/toc/1999-4923The objective of the optimization of pharmacotherapy compliant with the basic rules of clinical pharmacology is its maximum individualization, ensuring paramount effectiveness and security of the patient’s therapy. Thus, multiple factors that are decisive in terms of uniqueness of treatment of the given patient must be taken into consideration, including, but not limited to, the patient’s age, sex, concomitant diseases, special physiological conditions (e.g., pregnancy, lactation, extreme age groups), polypharmacotherapy and polypragmasia (particularly related to increased risk of drug interactions), and patient’s phenotypic response to the administered drug with possible genotyping. Conducting therapy while monitoring the concentration of certain drugs in blood (Therapeutic Drug Monitoring; TDM procedure) is also one of the factors enabling treatment individualization. Furthermore, another material, and yet still a marginalized pharmacotherapeutic factor, is chronopharmacology, which indirectly determines the values of drug concentrations evaluated in the TDM procedure. This paper is a brief overview of chronopharmacology, especially chronopharmacokinetics, and its connection with the clinical interpretation of the meaning of the drug concentrations determined in the TDM procedure.Lukasz DobrekMDPI AGarticlechronopharmacologycircadian rhythmtherapeutic drug monitoringchronopharmacokineticsPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1915, p 1915 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronopharmacology circadian rhythm therapeutic drug monitoring chronopharmacokinetics Pharmacy and materia medica RS1-441
spellingShingle	chronopharmacology circadian rhythm therapeutic drug monitoring chronopharmacokinetics Pharmacy and materia medica RS1-441 Lukasz Dobrek Chronopharmacology in Therapeutic Drug Monitoring—Dependencies between the Rhythmics of Pharmacokinetic Processes and Drug Concentration in Blood
description	The objective of the optimization of pharmacotherapy compliant with the basic rules of clinical pharmacology is its maximum individualization, ensuring paramount effectiveness and security of the patient’s therapy. Thus, multiple factors that are decisive in terms of uniqueness of treatment of the given patient must be taken into consideration, including, but not limited to, the patient’s age, sex, concomitant diseases, special physiological conditions (e.g., pregnancy, lactation, extreme age groups), polypharmacotherapy and polypragmasia (particularly related to increased risk of drug interactions), and patient’s phenotypic response to the administered drug with possible genotyping. Conducting therapy while monitoring the concentration of certain drugs in blood (Therapeutic Drug Monitoring; TDM procedure) is also one of the factors enabling treatment individualization. Furthermore, another material, and yet still a marginalized pharmacotherapeutic factor, is chronopharmacology, which indirectly determines the values of drug concentrations evaluated in the TDM procedure. This paper is a brief overview of chronopharmacology, especially chronopharmacokinetics, and its connection with the clinical interpretation of the meaning of the drug concentrations determined in the TDM procedure.
format	article
author	Lukasz Dobrek
author_facet	Lukasz Dobrek
author_sort	Lukasz Dobrek
title	Chronopharmacology in Therapeutic Drug Monitoring—Dependencies between the Rhythmics of Pharmacokinetic Processes and Drug Concentration in Blood
title_short	Chronopharmacology in Therapeutic Drug Monitoring—Dependencies between the Rhythmics of Pharmacokinetic Processes and Drug Concentration in Blood
title_full	Chronopharmacology in Therapeutic Drug Monitoring—Dependencies between the Rhythmics of Pharmacokinetic Processes and Drug Concentration in Blood
title_fullStr	Chronopharmacology in Therapeutic Drug Monitoring—Dependencies between the Rhythmics of Pharmacokinetic Processes and Drug Concentration in Blood
title_full_unstemmed	Chronopharmacology in Therapeutic Drug Monitoring—Dependencies between the Rhythmics of Pharmacokinetic Processes and Drug Concentration in Blood
title_sort	chronopharmacology in therapeutic drug monitoring—dependencies between the rhythmics of pharmacokinetic processes and drug concentration in blood
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/838a83b98d4f42dbabe419ba6ab7261e
work_keys_str_mv	AT lukaszdobrek chronopharmacologyintherapeuticdrugmonitoringdependenciesbetweentherhythmicsofpharmacokineticprocessesanddrugconcentrationinblood
_version_	1718410783707103232

Chronopharmacology in Therapeutic Drug Monitoring—Dependencies between the Rhythmics of Pharmacokinetic Processes and Drug Concentration in Blood

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