Modified N-linked glycosylation status predicts trafficking defective human Piezo1 channel mutations

Li et al. investigates the role of N-linked glycosylation for the function of mechanosensitive ion channel Piezo1. They show that disease-linked loss of function mutations in Piezo1 that are trafficking defective lack N-linked glycosylation.

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Detalles Bibliográficos
Autores principales:	Jinyuan Vero Li, Chai-Ann Ng, Delfine Cheng, Zijing Zhou, Mingxi Yao, Yang Guo, Ze-Yan Yu, Yogambha Ramaswamy, Lining Arnold Ju, Philip W. Kuchel, Michael P. Feneley, Diane Fatkin, Charles D. Cox
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/838c42e3bd25417ab25bf8adfdc60922
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spelling	oai:doaj.org-article:838c42e3bd25417ab25bf8adfdc609222021-12-02T17:19:12ZModified N-linked glycosylation status predicts trafficking defective human Piezo1 channel mutations10.1038/s42003-021-02528-w2399-3642https://doaj.org/article/838c42e3bd25417ab25bf8adfdc609222021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02528-whttps://doaj.org/toc/2399-3642Li et al. investigates the role of N-linked glycosylation for the function of mechanosensitive ion channel Piezo1. They show that disease-linked loss of function mutations in Piezo1 that are trafficking defective lack N-linked glycosylation.Jinyuan Vero LiChai-Ann NgDelfine ChengZijing ZhouMingxi YaoYang GuoZe-Yan YuYogambha RamaswamyLining Arnold JuPhilip W. KuchelMichael P. FeneleyDiane FatkinCharles D. CoxNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Jinyuan Vero Li Chai-Ann Ng Delfine Cheng Zijing Zhou Mingxi Yao Yang Guo Ze-Yan Yu Yogambha Ramaswamy Lining Arnold Ju Philip W. Kuchel Michael P. Feneley Diane Fatkin Charles D. Cox Modified N-linked glycosylation status predicts trafficking defective human Piezo1 channel mutations
description	Li et al. investigates the role of N-linked glycosylation for the function of mechanosensitive ion channel Piezo1. They show that disease-linked loss of function mutations in Piezo1 that are trafficking defective lack N-linked glycosylation.
format	article
author	Jinyuan Vero Li Chai-Ann Ng Delfine Cheng Zijing Zhou Mingxi Yao Yang Guo Ze-Yan Yu Yogambha Ramaswamy Lining Arnold Ju Philip W. Kuchel Michael P. Feneley Diane Fatkin Charles D. Cox
author_facet	Jinyuan Vero Li Chai-Ann Ng Delfine Cheng Zijing Zhou Mingxi Yao Yang Guo Ze-Yan Yu Yogambha Ramaswamy Lining Arnold Ju Philip W. Kuchel Michael P. Feneley Diane Fatkin Charles D. Cox
author_sort	Jinyuan Vero Li
title	Modified N-linked glycosylation status predicts trafficking defective human Piezo1 channel mutations
title_short	Modified N-linked glycosylation status predicts trafficking defective human Piezo1 channel mutations
title_full	Modified N-linked glycosylation status predicts trafficking defective human Piezo1 channel mutations
title_fullStr	Modified N-linked glycosylation status predicts trafficking defective human Piezo1 channel mutations
title_full_unstemmed	Modified N-linked glycosylation status predicts trafficking defective human Piezo1 channel mutations
title_sort	modified n-linked glycosylation status predicts trafficking defective human piezo1 channel mutations
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/838c42e3bd25417ab25bf8adfdc60922
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Modified N-linked glycosylation status predicts trafficking defective human Piezo1 channel mutations

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