Retinal Protection from LED-Backlit Screen Lights by Short Wavelength Absorption Filters

(1) Background: Ocular exposure to intense light or long-time exposure to low-intensity short-wavelength lights may cause eye injury. Excessive levels of blue light induce photochemical damage to the retinal pigment and degeneration of photoreceptors of the outer segments. Currently, people spend a...

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Autores principales:	Celia Sanchez-Ramos, Cristina Bonnin-Arias, Vanesa Blázquez-Sánchez, Victoria Aguirre-Vilacoro, Teresa Cobo, Olivia García-Suarez, María Jesús Perez-Carrasco, Cristina Alvarez-Peregrina, José A. Vega
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	retinal light injury LED screen optical filter retinal protection Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/838e447565e04a1483a906bb1a8fb2bf
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spelling	oai:doaj.org-article:838e447565e04a1483a906bb1a8fb2bf2021-11-25T17:13:16ZRetinal Protection from LED-Backlit Screen Lights by Short Wavelength Absorption Filters10.3390/cells101132482073-4409https://doaj.org/article/838e447565e04a1483a906bb1a8fb2bf2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3248https://doaj.org/toc/2073-4409(1) Background: Ocular exposure to intense light or long-time exposure to low-intensity short-wavelength lights may cause eye injury. Excessive levels of blue light induce photochemical damage to the retinal pigment and degeneration of photoreceptors of the outer segments. Currently, people spend a lot of time watching LED screens that emit high proportions of blue light. This study aims to assess the effects of light emitted by LED tablet screens on pigmented rat retinas with and without optical filters. (2) Methods: Commercially available tablets were used for exposure experiments on three groups of rats. One was exposed to tablet screens, the other was exposed to the tablet screens with a selective filter and the other was a control group. Structure, gene expression (including life/death, extracellular matrix degradation, growth factors, and oxidative stress related genes), and immunohistochemistry in the retina were compared among groups. (3) Results: There was a reduction of the thickness of the external nuclear layer and changes in the genes involved in cell survival and death, extracellular matrix turnover, growth factors, inflammation, and oxidative stress, leading decrease in cell density and retinal damage in the first group. Modulation of gene changes was observed when the LED light of screens was modified with an optical filter. (4) Conclusions: The use of short-wavelength selective filters on the screens contribute to reduce LED light-induced damage in the rat retina.Celia Sanchez-RamosCristina Bonnin-AriasVanesa Blázquez-SánchezVictoria Aguirre-VilacoroTeresa CoboOlivia García-SuarezMaría Jesús Perez-CarrascoCristina Alvarez-PeregrinaJosé A. VegaMDPI AGarticleretinal light injuryLED screenoptical filterretinal protectionBiology (General)QH301-705.5ENCells, Vol 10, Iss 3248, p 3248 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	retinal light injury LED screen optical filter retinal protection Biology (General) QH301-705.5
spellingShingle	retinal light injury LED screen optical filter retinal protection Biology (General) QH301-705.5 Celia Sanchez-Ramos Cristina Bonnin-Arias Vanesa Blázquez-Sánchez Victoria Aguirre-Vilacoro Teresa Cobo Olivia García-Suarez María Jesús Perez-Carrasco Cristina Alvarez-Peregrina José A. Vega Retinal Protection from LED-Backlit Screen Lights by Short Wavelength Absorption Filters
description	(1) Background: Ocular exposure to intense light or long-time exposure to low-intensity short-wavelength lights may cause eye injury. Excessive levels of blue light induce photochemical damage to the retinal pigment and degeneration of photoreceptors of the outer segments. Currently, people spend a lot of time watching LED screens that emit high proportions of blue light. This study aims to assess the effects of light emitted by LED tablet screens on pigmented rat retinas with and without optical filters. (2) Methods: Commercially available tablets were used for exposure experiments on three groups of rats. One was exposed to tablet screens, the other was exposed to the tablet screens with a selective filter and the other was a control group. Structure, gene expression (including life/death, extracellular matrix degradation, growth factors, and oxidative stress related genes), and immunohistochemistry in the retina were compared among groups. (3) Results: There was a reduction of the thickness of the external nuclear layer and changes in the genes involved in cell survival and death, extracellular matrix turnover, growth factors, inflammation, and oxidative stress, leading decrease in cell density and retinal damage in the first group. Modulation of gene changes was observed when the LED light of screens was modified with an optical filter. (4) Conclusions: The use of short-wavelength selective filters on the screens contribute to reduce LED light-induced damage in the rat retina.
format	article
author	Celia Sanchez-Ramos Cristina Bonnin-Arias Vanesa Blázquez-Sánchez Victoria Aguirre-Vilacoro Teresa Cobo Olivia García-Suarez María Jesús Perez-Carrasco Cristina Alvarez-Peregrina José A. Vega
author_facet	Celia Sanchez-Ramos Cristina Bonnin-Arias Vanesa Blázquez-Sánchez Victoria Aguirre-Vilacoro Teresa Cobo Olivia García-Suarez María Jesús Perez-Carrasco Cristina Alvarez-Peregrina José A. Vega
author_sort	Celia Sanchez-Ramos
title	Retinal Protection from LED-Backlit Screen Lights by Short Wavelength Absorption Filters
title_short	Retinal Protection from LED-Backlit Screen Lights by Short Wavelength Absorption Filters
title_full	Retinal Protection from LED-Backlit Screen Lights by Short Wavelength Absorption Filters
title_fullStr	Retinal Protection from LED-Backlit Screen Lights by Short Wavelength Absorption Filters
title_full_unstemmed	Retinal Protection from LED-Backlit Screen Lights by Short Wavelength Absorption Filters
title_sort	retinal protection from led-backlit screen lights by short wavelength absorption filters
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/838e447565e04a1483a906bb1a8fb2bf
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Retinal Protection from LED-Backlit Screen Lights by Short Wavelength Absorption Filters

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