GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11

Growth hormone (GH) is a major modulator of physical growth and metabolism that is under tight regulatory control. Here the authors describe the signaling profile of GPR101, an orphan receptor that enhances GH secretion principally via constitutively activated Gs-PKA and Gq/11-PKC pathways.

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Autores principales:	Dayana Abboud, Adrian F. Daly, Nadine Dupuis, Mohamed Ali Bahri, Asuka Inoue, Andy Chevigné, Fabien Ectors, Alain Plenevaux, Bernard Pirotte, Albert Beckers, Julien Hanson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/839017688b1d4d559b0f157b0b3d14dd
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spelling	oai:doaj.org-article:839017688b1d4d559b0f157b0b3d14dd2021-12-02T15:14:38ZGPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/1110.1038/s41467-020-18500-x2041-1723https://doaj.org/article/839017688b1d4d559b0f157b0b3d14dd2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18500-xhttps://doaj.org/toc/2041-1723Growth hormone (GH) is a major modulator of physical growth and metabolism that is under tight regulatory control. Here the authors describe the signaling profile of GPR101, an orphan receptor that enhances GH secretion principally via constitutively activated Gs-PKA and Gq/11-PKC pathways.Dayana AbboudAdrian F. DalyNadine DupuisMohamed Ali BahriAsuka InoueAndy ChevignéFabien EctorsAlain PlenevauxBernard PirotteAlbert BeckersJulien HansonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dayana Abboud Adrian F. Daly Nadine Dupuis Mohamed Ali Bahri Asuka Inoue Andy Chevigné Fabien Ectors Alain Plenevaux Bernard Pirotte Albert Beckers Julien Hanson GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11
description	Growth hormone (GH) is a major modulator of physical growth and metabolism that is under tight regulatory control. Here the authors describe the signaling profile of GPR101, an orphan receptor that enhances GH secretion principally via constitutively activated Gs-PKA and Gq/11-PKC pathways.
format	article
author	Dayana Abboud Adrian F. Daly Nadine Dupuis Mohamed Ali Bahri Asuka Inoue Andy Chevigné Fabien Ectors Alain Plenevaux Bernard Pirotte Albert Beckers Julien Hanson
author_facet	Dayana Abboud Adrian F. Daly Nadine Dupuis Mohamed Ali Bahri Asuka Inoue Andy Chevigné Fabien Ectors Alain Plenevaux Bernard Pirotte Albert Beckers Julien Hanson
author_sort	Dayana Abboud
title	GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11
title_short	GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11
title_full	GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11
title_fullStr	GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11
title_full_unstemmed	GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11
title_sort	gpr101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of gs and gq/11
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/839017688b1d4d559b0f157b0b3d14dd
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GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11

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