Transcriptional response to stress is pre-wired by promoter and enhancer architecture

Heat Shock Factor 1 (HSF1) is a regulator of stress-induced transcription. Here, the authors investigate changes to transcription and chromatin organization upon stress and find that activated HSF1 binds to transcription-primed promoters and enhancers, and to CTCF occupied, untranscribed chromatin.

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Autores principales:	Anniina Vihervaara, Dig Bijay Mahat, Michael J. Guertin, Tinyi Chu, Charles G. Danko, John T. Lis, Lea Sistonen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8396af8fe6874b93839c2a87662af811
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spelling	oai:doaj.org-article:8396af8fe6874b93839c2a87662af8112021-12-02T14:16:14ZTranscriptional response to stress is pre-wired by promoter and enhancer architecture10.1038/s41467-017-00151-02041-1723https://doaj.org/article/8396af8fe6874b93839c2a87662af8112017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00151-0https://doaj.org/toc/2041-1723Heat Shock Factor 1 (HSF1) is a regulator of stress-induced transcription. Here, the authors investigate changes to transcription and chromatin organization upon stress and find that activated HSF1 binds to transcription-primed promoters and enhancers, and to CTCF occupied, untranscribed chromatin.Anniina VihervaaraDig Bijay MahatMichael J. GuertinTinyi ChuCharles G. DankoJohn T. LisLea SistonenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anniina Vihervaara Dig Bijay Mahat Michael J. Guertin Tinyi Chu Charles G. Danko John T. Lis Lea Sistonen Transcriptional response to stress is pre-wired by promoter and enhancer architecture
description	Heat Shock Factor 1 (HSF1) is a regulator of stress-induced transcription. Here, the authors investigate changes to transcription and chromatin organization upon stress and find that activated HSF1 binds to transcription-primed promoters and enhancers, and to CTCF occupied, untranscribed chromatin.
format	article
author	Anniina Vihervaara Dig Bijay Mahat Michael J. Guertin Tinyi Chu Charles G. Danko John T. Lis Lea Sistonen
author_facet	Anniina Vihervaara Dig Bijay Mahat Michael J. Guertin Tinyi Chu Charles G. Danko John T. Lis Lea Sistonen
author_sort	Anniina Vihervaara
title	Transcriptional response to stress is pre-wired by promoter and enhancer architecture
title_short	Transcriptional response to stress is pre-wired by promoter and enhancer architecture
title_full	Transcriptional response to stress is pre-wired by promoter and enhancer architecture
title_fullStr	Transcriptional response to stress is pre-wired by promoter and enhancer architecture
title_full_unstemmed	Transcriptional response to stress is pre-wired by promoter and enhancer architecture
title_sort	transcriptional response to stress is pre-wired by promoter and enhancer architecture
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8396af8fe6874b93839c2a87662af811
work_keys_str_mv	AT anniinavihervaara transcriptionalresponsetostressisprewiredbypromoterandenhancerarchitecture AT digbijaymahat transcriptionalresponsetostressisprewiredbypromoterandenhancerarchitecture AT michaeljguertin transcriptionalresponsetostressisprewiredbypromoterandenhancerarchitecture AT tinyichu transcriptionalresponsetostressisprewiredbypromoterandenhancerarchitecture AT charlesgdanko transcriptionalresponsetostressisprewiredbypromoterandenhancerarchitecture AT johntlis transcriptionalresponsetostressisprewiredbypromoterandenhancerarchitecture AT leasistonen transcriptionalresponsetostressisprewiredbypromoterandenhancerarchitecture
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Transcriptional response to stress is pre-wired by promoter and enhancer architecture

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