The diagnostic value of human epididymis protein 4 for endometrial cancer is moderate

Abstract Human epididymis protein 4 (HE4) has been used as a biomarker of endometrial cancer (EC) in clinical practice. However, there remains a lack of systemic research on the critical values of HE4 for diagnosing different clinical stages and pathological types of EC. This study investigated the...

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Autores principales:	Jing Liu, Lili Han, Zhen Jiao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8398af0c322b48b5b8fb64feacd7c497
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spelling	oai:doaj.org-article:8398af0c322b48b5b8fb64feacd7c4972021-12-02T15:23:00ZThe diagnostic value of human epididymis protein 4 for endometrial cancer is moderate10.1038/s41598-020-79960-12045-2322https://doaj.org/article/8398af0c322b48b5b8fb64feacd7c4972021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79960-1https://doaj.org/toc/2045-2322Abstract Human epididymis protein 4 (HE4) has been used as a biomarker of endometrial cancer (EC) in clinical practice. However, there remains a lack of systemic research on the critical values of HE4 for diagnosing different clinical stages and pathological types of EC. This study investigated the accuracy of human epididymis protein 4 (HE4) in the diagnosis of EC. Patients who were hospitalized for a chief complaint of abnormal vaginal hemorrhage at Xinjiang Uyghur Autonomous Region People's Hospital between 2014 and 2019 were consecutively included. Pathological biopsy confirmed the diagnosis of EC; there were a total of 136 EC patients and 127 non-EC patients. The accuracy of HE4 in the diagnosis of EC was assessed with SPSS software. The accuracy of HE4 for diagnosing different clinical stages and pathological types of EC was also explored. The critical value of HE4 for endometrial cancer was 52.40 mmol/L, with a sensitivity of 57.35% and a specificity of 76.38%. For different stages of EC, the critical value was 36.9 mmol/L, and the sensitivity and specificity were 28% and 87.39%, respectively. For different pathological types, the critical value was 30.60 mmol/L, and the sensitivity and specificity were 93.85% and 33.33%, respectively. The diagnostic value of HE4 for EC is moderate, and the serum HE4 level cannot reflect the stage and type of EC.Jing LiuLili HanZhen JiaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jing Liu Lili Han Zhen Jiao The diagnostic value of human epididymis protein 4 for endometrial cancer is moderate
description	Abstract Human epididymis protein 4 (HE4) has been used as a biomarker of endometrial cancer (EC) in clinical practice. However, there remains a lack of systemic research on the critical values of HE4 for diagnosing different clinical stages and pathological types of EC. This study investigated the accuracy of human epididymis protein 4 (HE4) in the diagnosis of EC. Patients who were hospitalized for a chief complaint of abnormal vaginal hemorrhage at Xinjiang Uyghur Autonomous Region People's Hospital between 2014 and 2019 were consecutively included. Pathological biopsy confirmed the diagnosis of EC; there were a total of 136 EC patients and 127 non-EC patients. The accuracy of HE4 in the diagnosis of EC was assessed with SPSS software. The accuracy of HE4 for diagnosing different clinical stages and pathological types of EC was also explored. The critical value of HE4 for endometrial cancer was 52.40 mmol/L, with a sensitivity of 57.35% and a specificity of 76.38%. For different stages of EC, the critical value was 36.9 mmol/L, and the sensitivity and specificity were 28% and 87.39%, respectively. For different pathological types, the critical value was 30.60 mmol/L, and the sensitivity and specificity were 93.85% and 33.33%, respectively. The diagnostic value of HE4 for EC is moderate, and the serum HE4 level cannot reflect the stage and type of EC.
format	article
author	Jing Liu Lili Han Zhen Jiao
author_facet	Jing Liu Lili Han Zhen Jiao
author_sort	Jing Liu
title	The diagnostic value of human epididymis protein 4 for endometrial cancer is moderate
title_short	The diagnostic value of human epididymis protein 4 for endometrial cancer is moderate
title_full	The diagnostic value of human epididymis protein 4 for endometrial cancer is moderate
title_fullStr	The diagnostic value of human epididymis protein 4 for endometrial cancer is moderate
title_full_unstemmed	The diagnostic value of human epididymis protein 4 for endometrial cancer is moderate
title_sort	diagnostic value of human epididymis protein 4 for endometrial cancer is moderate
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8398af0c322b48b5b8fb64feacd7c497
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The diagnostic value of human epididymis protein 4 for endometrial cancer is moderate

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