Possible Benefits of Faecalibacterium prausnitzii for Obesity-Associated Gut Disorders
Metabolic disorders are an increasing concern in the industrialized world. Current research has shown a direct link between the composition of the gut microbiota and the pathogenesis of obesity and diabetes. In only a few weeks, an obesity-inducing diet can lead to increased gut permeability and mic...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:839bba87e30345c781371a2ae6c1acf92021-12-02T11:39:11ZPossible Benefits of Faecalibacterium prausnitzii for Obesity-Associated Gut Disorders1663-981210.3389/fphar.2021.740636https://doaj.org/article/839bba87e30345c781371a2ae6c1acf92021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.740636/fullhttps://doaj.org/toc/1663-9812Metabolic disorders are an increasing concern in the industrialized world. Current research has shown a direct link between the composition of the gut microbiota and the pathogenesis of obesity and diabetes. In only a few weeks, an obesity-inducing diet can lead to increased gut permeability and microbial dysbiosis, which contributes to chronic inflammation in the gut and adipose tissues, and to the development of insulin resistance. In this review, we examine the interplay between gut inflammation, insulin resistance, and the gut microbiota, and discuss how some probiotic species can be used to modulate gut homeostasis. We focus primarily on Faecalibacterium prausnitzii, a highly abundant butyrate-producing bacterium that has been proposed both as a biomarker for the development of different gut pathologies and as a potential treatment due to its production of anti-inflammatory metabolites.Tatiani Uceli MaioliTatiani Uceli MaioliEsther Borras-NoguesLicia TorresSara Candida BarbosaVinicius Dantas MartinsPhilippe LangellaVasco Ariston AzevedoJean-Marc ChatelFrontiers Media S.A.articlediabetesgut permeabilityobesityprobioticsFaecalibacterium prausnitziiTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021) |
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DOAJ |
| language |
EN |
| topic |
diabetes gut permeability obesity probiotics Faecalibacterium prausnitzii Therapeutics. Pharmacology RM1-950 |
| spellingShingle |
diabetes gut permeability obesity probiotics Faecalibacterium prausnitzii Therapeutics. Pharmacology RM1-950 Tatiani Uceli Maioli Tatiani Uceli Maioli Esther Borras-Nogues Licia Torres Sara Candida Barbosa Vinicius Dantas Martins Philippe Langella Vasco Ariston Azevedo Jean-Marc Chatel Possible Benefits of Faecalibacterium prausnitzii for Obesity-Associated Gut Disorders |
| description |
Metabolic disorders are an increasing concern in the industrialized world. Current research has shown a direct link between the composition of the gut microbiota and the pathogenesis of obesity and diabetes. In only a few weeks, an obesity-inducing diet can lead to increased gut permeability and microbial dysbiosis, which contributes to chronic inflammation in the gut and adipose tissues, and to the development of insulin resistance. In this review, we examine the interplay between gut inflammation, insulin resistance, and the gut microbiota, and discuss how some probiotic species can be used to modulate gut homeostasis. We focus primarily on Faecalibacterium prausnitzii, a highly abundant butyrate-producing bacterium that has been proposed both as a biomarker for the development of different gut pathologies and as a potential treatment due to its production of anti-inflammatory metabolites. |
| format |
article |
| author |
Tatiani Uceli Maioli Tatiani Uceli Maioli Esther Borras-Nogues Licia Torres Sara Candida Barbosa Vinicius Dantas Martins Philippe Langella Vasco Ariston Azevedo Jean-Marc Chatel |
| author_facet |
Tatiani Uceli Maioli Tatiani Uceli Maioli Esther Borras-Nogues Licia Torres Sara Candida Barbosa Vinicius Dantas Martins Philippe Langella Vasco Ariston Azevedo Jean-Marc Chatel |
| author_sort |
Tatiani Uceli Maioli |
| title |
Possible Benefits of Faecalibacterium prausnitzii for Obesity-Associated Gut Disorders |
| title_short |
Possible Benefits of Faecalibacterium prausnitzii for Obesity-Associated Gut Disorders |
| title_full |
Possible Benefits of Faecalibacterium prausnitzii for Obesity-Associated Gut Disorders |
| title_fullStr |
Possible Benefits of Faecalibacterium prausnitzii for Obesity-Associated Gut Disorders |
| title_full_unstemmed |
Possible Benefits of Faecalibacterium prausnitzii for Obesity-Associated Gut Disorders |
| title_sort |
possible benefits of faecalibacterium prausnitzii for obesity-associated gut disorders |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/839bba87e30345c781371a2ae6c1acf9 |
| work_keys_str_mv |
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