Effects of Transcutaneous Electrical Acupoint Stimulation on Postoperative Cognitive Decline in Elderly Patients: A Pilot Study
Tianlin Liu,1,2 Chunping Yin,1 Yanan Li,1 Fang Gao,1 Lili Yu,1,2 Zhigang Wang,1 Qiujun Wang1 1Department of Anesthesiology, The Third Hospital of Hebei Medical University, Shijiazhuang City, Hebei, People’s Republic of China; 2Department of Anesthesiology, Cangzhou Central Hospital, Cangzh...
Guardado en:
| Autores principales: | , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/83a4a06391054acc9c330ca839fe8115 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:83a4a06391054acc9c330ca839fe8115 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:83a4a06391054acc9c330ca839fe81152021-12-02T15:20:04ZEffects of Transcutaneous Electrical Acupoint Stimulation on Postoperative Cognitive Decline in Elderly Patients: A Pilot Study1178-1998https://doaj.org/article/83a4a06391054acc9c330ca839fe81152021-05-01T00:00:00Zhttps://www.dovepress.com/effects-of-transcutaneous-electrical-acupoint-stimulation-on-postopera-peer-reviewed-fulltext-article-CIAhttps://doaj.org/toc/1178-1998Tianlin Liu,1,2 Chunping Yin,1 Yanan Li,1 Fang Gao,1 Lili Yu,1,2 Zhigang Wang,1 Qiujun Wang1 1Department of Anesthesiology, The Third Hospital of Hebei Medical University, Shijiazhuang City, Hebei, People’s Republic of China; 2Department of Anesthesiology, Cangzhou Central Hospital, Cangzhou, Hebei, People’s Republic of ChinaCorrespondence: Qiujun Wang Tel +86 311 8860 2072Email wangqiujunsy@163.comBackground: Postoperative cognitive decline (POCD) in the old ages seriously delays the rapid recovery. Here, we aimed to investigate the effects of transcutaneous electrical acupoint stimulation (TEAS) against POCD in elderly patients undergoing laparoscopic radical colon cancer surgery, as well as the potential mechanism.Methods: A prospective, single-center, parallel-group, randomized trial was designed. A total of 100 patients (age ≥ 65 years) undergoing laparoscopic radical resection of colon cancer were involved and randomly divided into TEAS (Group T) and control (Group C) groups. The patients in Group T were performed with percutaneous acupoint electrical stimulation in bilateral Hegu, Neiguan and Zusanli points from 30 minutes before anesthesia induction to the end of surgery. A Z-score based on Mini-Mental State Exam (MMSE) was used to assess the incidence of POCD. The levels of serum IL-6, hs-CRP, CGRP at 0 min before TEAS (T0), 1 h after beginning of surgery (T1) and the end of surgery (T2) were evaluated.Results: Our data showed that the cumulative duration of POCD on postoperative day 2 and 3 in Group T was significantly decreased compared to Group C (P < 0.05). Compared with T0, the levels of serum IL-6, hs-CRP, and CGRP in both Group T and C were statistically elevated at T1 and T2 (P < 0.05). Moreover, the levels of serum IL-6 and hs-CRP were decreased, but the level of CGRP was increased in Group T compared to Group C at T1 and T2 (P < 0.05).Conclusion: TEAS is associated with a lower cumulative duration of POCD in elderly patients undergoing laparoscopic radical colon cancer surgery, which may be related to the regulation of inflammatory factors and neuropeptides interacted with gut–brain axis.Keywords: cognitive decline, gut–brain axis, transcutaneous electrical acupoint stimulation, colon cancer, elderLiu TYin CLi YGao FYu LWang ZWang QDove Medical Pressarticlecognitive declinegut–brain axistranscutaneous electrical acupoint stimulationcolon cancerelderGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 16, Pp 757-765 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
cognitive decline gut–brain axis transcutaneous electrical acupoint stimulation colon cancer elder Geriatrics RC952-954.6 |
| spellingShingle |
cognitive decline gut–brain axis transcutaneous electrical acupoint stimulation colon cancer elder Geriatrics RC952-954.6 Liu T Yin C Li Y Gao F Yu L Wang Z Wang Q Effects of Transcutaneous Electrical Acupoint Stimulation on Postoperative Cognitive Decline in Elderly Patients: A Pilot Study |
| description |
Tianlin Liu,1,2 Chunping Yin,1 Yanan Li,1 Fang Gao,1 Lili Yu,1,2 Zhigang Wang,1 Qiujun Wang1 1Department of Anesthesiology, The Third Hospital of Hebei Medical University, Shijiazhuang City, Hebei, People’s Republic of China; 2Department of Anesthesiology, Cangzhou Central Hospital, Cangzhou, Hebei, People’s Republic of ChinaCorrespondence: Qiujun Wang Tel +86 311 8860 2072Email wangqiujunsy@163.comBackground: Postoperative cognitive decline (POCD) in the old ages seriously delays the rapid recovery. Here, we aimed to investigate the effects of transcutaneous electrical acupoint stimulation (TEAS) against POCD in elderly patients undergoing laparoscopic radical colon cancer surgery, as well as the potential mechanism.Methods: A prospective, single-center, parallel-group, randomized trial was designed. A total of 100 patients (age ≥ 65 years) undergoing laparoscopic radical resection of colon cancer were involved and randomly divided into TEAS (Group T) and control (Group C) groups. The patients in Group T were performed with percutaneous acupoint electrical stimulation in bilateral Hegu, Neiguan and Zusanli points from 30 minutes before anesthesia induction to the end of surgery. A Z-score based on Mini-Mental State Exam (MMSE) was used to assess the incidence of POCD. The levels of serum IL-6, hs-CRP, CGRP at 0 min before TEAS (T0), 1 h after beginning of surgery (T1) and the end of surgery (T2) were evaluated.Results: Our data showed that the cumulative duration of POCD on postoperative day 2 and 3 in Group T was significantly decreased compared to Group C (P < 0.05). Compared with T0, the levels of serum IL-6, hs-CRP, and CGRP in both Group T and C were statistically elevated at T1 and T2 (P < 0.05). Moreover, the levels of serum IL-6 and hs-CRP were decreased, but the level of CGRP was increased in Group T compared to Group C at T1 and T2 (P < 0.05).Conclusion: TEAS is associated with a lower cumulative duration of POCD in elderly patients undergoing laparoscopic radical colon cancer surgery, which may be related to the regulation of inflammatory factors and neuropeptides interacted with gut–brain axis.Keywords: cognitive decline, gut–brain axis, transcutaneous electrical acupoint stimulation, colon cancer, elder |
| format |
article |
| author |
Liu T Yin C Li Y Gao F Yu L Wang Z Wang Q |
| author_facet |
Liu T Yin C Li Y Gao F Yu L Wang Z Wang Q |
| author_sort |
Liu T |
| title |
Effects of Transcutaneous Electrical Acupoint Stimulation on Postoperative Cognitive Decline in Elderly Patients: A Pilot Study |
| title_short |
Effects of Transcutaneous Electrical Acupoint Stimulation on Postoperative Cognitive Decline in Elderly Patients: A Pilot Study |
| title_full |
Effects of Transcutaneous Electrical Acupoint Stimulation on Postoperative Cognitive Decline in Elderly Patients: A Pilot Study |
| title_fullStr |
Effects of Transcutaneous Electrical Acupoint Stimulation on Postoperative Cognitive Decline in Elderly Patients: A Pilot Study |
| title_full_unstemmed |
Effects of Transcutaneous Electrical Acupoint Stimulation on Postoperative Cognitive Decline in Elderly Patients: A Pilot Study |
| title_sort |
effects of transcutaneous electrical acupoint stimulation on postoperative cognitive decline in elderly patients: a pilot study |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/83a4a06391054acc9c330ca839fe8115 |
| work_keys_str_mv |
AT liut effectsoftranscutaneouselectricalacupointstimulationonpostoperativecognitivedeclineinelderlypatientsapilotstudy AT yinc effectsoftranscutaneouselectricalacupointstimulationonpostoperativecognitivedeclineinelderlypatientsapilotstudy AT liy effectsoftranscutaneouselectricalacupointstimulationonpostoperativecognitivedeclineinelderlypatientsapilotstudy AT gaof effectsoftranscutaneouselectricalacupointstimulationonpostoperativecognitivedeclineinelderlypatientsapilotstudy AT yul effectsoftranscutaneouselectricalacupointstimulationonpostoperativecognitivedeclineinelderlypatientsapilotstudy AT wangz effectsoftranscutaneouselectricalacupointstimulationonpostoperativecognitivedeclineinelderlypatientsapilotstudy AT wangq effectsoftranscutaneouselectricalacupointstimulationonpostoperativecognitivedeclineinelderlypatientsapilotstudy |
| _version_ |
1718387417199673344 |