Quantifying changes over 1 year in motor and cognitive skill after transient ischemic attack (TIA) using robotics

Abstract Recent work has highlighted that people who have had TIA may have abnormal motor and cognitive function. We aimed to quantify deficits in a cohort of individuals who had TIA and measured changes in their abilities to perform behavioural tasks over 1 year of follow-up using the Kinarm Exoske...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Leif E. R. Simmatis, Stephen H. Scott, Albert Y. Jin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/83a6d777b31d4e8998667090bedfa6da
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:83a6d777b31d4e8998667090bedfa6da
record_format	dspace
spelling	oai:doaj.org-article:83a6d777b31d4e8998667090bedfa6da2021-12-02T15:09:16ZQuantifying changes over 1 year in motor and cognitive skill after transient ischemic attack (TIA) using robotics10.1038/s41598-021-96177-y2045-2322https://doaj.org/article/83a6d777b31d4e8998667090bedfa6da2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96177-yhttps://doaj.org/toc/2045-2322Abstract Recent work has highlighted that people who have had TIA may have abnormal motor and cognitive function. We aimed to quantify deficits in a cohort of individuals who had TIA and measured changes in their abilities to perform behavioural tasks over 1 year of follow-up using the Kinarm Exoskeleton robot. We additionally considered performance and change over time in an active control cohort of migraineurs. Individuals who had TIA or migraine completed 8 behavioural tasks that assessed cognition as well as motor and sensory functionality in the arm. Participants in the TIA cohort were assessed at 2, 6, 12, and 52 weeks after symptom resolution. Migraineurs were assessed at 2 and 52 weeks after symptom resolution. We measured overall performance on each task using an aggregate metric called Task Score and quantified any significant change in performance including the potential influence of learning. We recruited 48 individuals to the TIA cohort and 28 individuals to the migraine cohort. Individuals in both groups displayed impairments on robotic tasks within 2 weeks of symptom cessation and also at approximately 1 year after symptom cessation, most commonly in tests of cognitive-motor integration. Up to 51.3% of people in the TIA cohort demonstrated an impairment on a given task within 2-weeks of symptom resolution, and up to 27.3% had an impairment after 1 year. In the migraine group, these numbers were 37.5% and 31.6%, respectively. We identified that up to 18% of participants in the TIA group, and up to 10% in the migraine group, displayed impairments that persisted for up to 1 year after symptom resolution. Finally, we determined that a subset of both cohorts (25–30%) experienced statistically significant deteriorations in performance after 1 year. People who have experienced transient neurological symptoms, such as those that arise from TIA or migraine, may continue to experience lasting neurological impairments. Most individuals had relatively stable task performance over time, with some impairments persisting for up to 1 year. However, some individuals demonstrated substantial changes in performance, which highlights the heterogeneity of these neurological disorders. These findings demonstrate the need to consider factors that contribute to lasting neurological impairment, approaches that could be developed to alleviate the lasting effects of TIA or migraine, and the need to consider individual neurological status, even following transient neurological symptoms.Leif E. R. SimmatisStephen H. ScottAlbert Y. JinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Leif E. R. Simmatis Stephen H. Scott Albert Y. Jin Quantifying changes over 1 year in motor and cognitive skill after transient ischemic attack (TIA) using robotics
description	Abstract Recent work has highlighted that people who have had TIA may have abnormal motor and cognitive function. We aimed to quantify deficits in a cohort of individuals who had TIA and measured changes in their abilities to perform behavioural tasks over 1 year of follow-up using the Kinarm Exoskeleton robot. We additionally considered performance and change over time in an active control cohort of migraineurs. Individuals who had TIA or migraine completed 8 behavioural tasks that assessed cognition as well as motor and sensory functionality in the arm. Participants in the TIA cohort were assessed at 2, 6, 12, and 52 weeks after symptom resolution. Migraineurs were assessed at 2 and 52 weeks after symptom resolution. We measured overall performance on each task using an aggregate metric called Task Score and quantified any significant change in performance including the potential influence of learning. We recruited 48 individuals to the TIA cohort and 28 individuals to the migraine cohort. Individuals in both groups displayed impairments on robotic tasks within 2 weeks of symptom cessation and also at approximately 1 year after symptom cessation, most commonly in tests of cognitive-motor integration. Up to 51.3% of people in the TIA cohort demonstrated an impairment on a given task within 2-weeks of symptom resolution, and up to 27.3% had an impairment after 1 year. In the migraine group, these numbers were 37.5% and 31.6%, respectively. We identified that up to 18% of participants in the TIA group, and up to 10% in the migraine group, displayed impairments that persisted for up to 1 year after symptom resolution. Finally, we determined that a subset of both cohorts (25–30%) experienced statistically significant deteriorations in performance after 1 year. People who have experienced transient neurological symptoms, such as those that arise from TIA or migraine, may continue to experience lasting neurological impairments. Most individuals had relatively stable task performance over time, with some impairments persisting for up to 1 year. However, some individuals demonstrated substantial changes in performance, which highlights the heterogeneity of these neurological disorders. These findings demonstrate the need to consider factors that contribute to lasting neurological impairment, approaches that could be developed to alleviate the lasting effects of TIA or migraine, and the need to consider individual neurological status, even following transient neurological symptoms.
format	article
author	Leif E. R. Simmatis Stephen H. Scott Albert Y. Jin
author_facet	Leif E. R. Simmatis Stephen H. Scott Albert Y. Jin
author_sort	Leif E. R. Simmatis
title	Quantifying changes over 1 year in motor and cognitive skill after transient ischemic attack (TIA) using robotics
title_short	Quantifying changes over 1 year in motor and cognitive skill after transient ischemic attack (TIA) using robotics
title_full	Quantifying changes over 1 year in motor and cognitive skill after transient ischemic attack (TIA) using robotics
title_fullStr	Quantifying changes over 1 year in motor and cognitive skill after transient ischemic attack (TIA) using robotics
title_full_unstemmed	Quantifying changes over 1 year in motor and cognitive skill after transient ischemic attack (TIA) using robotics
title_sort	quantifying changes over 1 year in motor and cognitive skill after transient ischemic attack (tia) using robotics
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/83a6d777b31d4e8998667090bedfa6da
work_keys_str_mv	AT leifersimmatis quantifyingchangesover1yearinmotorandcognitiveskillaftertransientischemicattacktiausingrobotics AT stephenhscott quantifyingchangesover1yearinmotorandcognitiveskillaftertransientischemicattacktiausingrobotics AT albertyjin quantifyingchangesover1yearinmotorandcognitiveskillaftertransientischemicattacktiausingrobotics
_version_	1718387885109936128

Quantifying changes over 1 year in motor and cognitive skill after transient ischemic attack (TIA) using robotics

Ejemplares similares