Liver lymphatic drainage patterns follow segmental anatomy in a murine model

Abstract The liver’s cellular functions are sustained by a hierarchical, segmentally-organized vascular system. Additionally, liver lymphatic vessels are thought to drain to perihepatic lymph nodes. Surprisingly, while recent findings highlight the importance of organ-specific lymphatics, the functi...

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Autores principales:	Nicola C. Frenkel, Susanna Poghosyan, André Verheem, Timothy P. Padera, Inne H. M. Borel Rinkes, Onno Kranenburg, Jeroen Hagendoorn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/83a9268bbc9c4e1cb850f89e226f267c
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spelling	oai:doaj.org-article:83a9268bbc9c4e1cb850f89e226f267c2021-12-02T16:18:06ZLiver lymphatic drainage patterns follow segmental anatomy in a murine model10.1038/s41598-020-78727-y2045-2322https://doaj.org/article/83a9268bbc9c4e1cb850f89e226f267c2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78727-yhttps://doaj.org/toc/2045-2322Abstract The liver’s cellular functions are sustained by a hierarchical, segmentally-organized vascular system. Additionally, liver lymphatic vessels are thought to drain to perihepatic lymph nodes. Surprisingly, while recent findings highlight the importance of organ-specific lymphatics, the functional anatomy of liver lymphatics has not been mapped out. In literature, no segmental or preferential lymphatic drainage patterns are known to exist. We employ a novel murine model of liver lymphangiography and in vivo microscopy to delineate the lymphatic drainage patterns of individual liver lobes. Our data from blue dye liver lymphangiography show preferential lymphatic drainage patterns: Right lobe mainly to hepatoduodenal ligament lymph node 1 (LN1); left lobe to hepatoduodenal ligament LN1 + LN2 concurrently; median lobe showed a more variable LN1/LN2 drainage pattern with increased (sometimes exclusive) mediastinal thoracic lymph node involvement, indicating that part of the liver can drain directly to the mediastinum. Upon ferritin lymphangiography, we observed no functional communication between the lobar lymphatics. Altogether, these results show the existence of preferential lymphatic drainage patterns in the murine liver. Moreover, this drainage can occur directly to mediastinal lymph nodes and there is no interlobar lymphatic flow. Collectively, these data provide the first direct evidence that liver lymphatic drainage patterns follow segmental anatomy.Nicola C. FrenkelSusanna PoghosyanAndré VerheemTimothy P. PaderaInne H. M. Borel RinkesOnno KranenburgJeroen HagendoornNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nicola C. Frenkel Susanna Poghosyan André Verheem Timothy P. Padera Inne H. M. Borel Rinkes Onno Kranenburg Jeroen Hagendoorn Liver lymphatic drainage patterns follow segmental anatomy in a murine model
description	Abstract The liver’s cellular functions are sustained by a hierarchical, segmentally-organized vascular system. Additionally, liver lymphatic vessels are thought to drain to perihepatic lymph nodes. Surprisingly, while recent findings highlight the importance of organ-specific lymphatics, the functional anatomy of liver lymphatics has not been mapped out. In literature, no segmental or preferential lymphatic drainage patterns are known to exist. We employ a novel murine model of liver lymphangiography and in vivo microscopy to delineate the lymphatic drainage patterns of individual liver lobes. Our data from blue dye liver lymphangiography show preferential lymphatic drainage patterns: Right lobe mainly to hepatoduodenal ligament lymph node 1 (LN1); left lobe to hepatoduodenal ligament LN1 + LN2 concurrently; median lobe showed a more variable LN1/LN2 drainage pattern with increased (sometimes exclusive) mediastinal thoracic lymph node involvement, indicating that part of the liver can drain directly to the mediastinum. Upon ferritin lymphangiography, we observed no functional communication between the lobar lymphatics. Altogether, these results show the existence of preferential lymphatic drainage patterns in the murine liver. Moreover, this drainage can occur directly to mediastinal lymph nodes and there is no interlobar lymphatic flow. Collectively, these data provide the first direct evidence that liver lymphatic drainage patterns follow segmental anatomy.
format	article
author	Nicola C. Frenkel Susanna Poghosyan André Verheem Timothy P. Padera Inne H. M. Borel Rinkes Onno Kranenburg Jeroen Hagendoorn
author_facet	Nicola C. Frenkel Susanna Poghosyan André Verheem Timothy P. Padera Inne H. M. Borel Rinkes Onno Kranenburg Jeroen Hagendoorn
author_sort	Nicola C. Frenkel
title	Liver lymphatic drainage patterns follow segmental anatomy in a murine model
title_short	Liver lymphatic drainage patterns follow segmental anatomy in a murine model
title_full	Liver lymphatic drainage patterns follow segmental anatomy in a murine model
title_fullStr	Liver lymphatic drainage patterns follow segmental anatomy in a murine model
title_full_unstemmed	Liver lymphatic drainage patterns follow segmental anatomy in a murine model
title_sort	liver lymphatic drainage patterns follow segmental anatomy in a murine model
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/83a9268bbc9c4e1cb850f89e226f267c
work_keys_str_mv	AT nicolacfrenkel liverlymphaticdrainagepatternsfollowsegmentalanatomyinamurinemodel AT susannapoghosyan liverlymphaticdrainagepatternsfollowsegmentalanatomyinamurinemodel AT andreverheem liverlymphaticdrainagepatternsfollowsegmentalanatomyinamurinemodel AT timothyppadera liverlymphaticdrainagepatternsfollowsegmentalanatomyinamurinemodel AT innehmborelrinkes liverlymphaticdrainagepatternsfollowsegmentalanatomyinamurinemodel AT onnokranenburg liverlymphaticdrainagepatternsfollowsegmentalanatomyinamurinemodel AT jeroenhagendoorn liverlymphaticdrainagepatternsfollowsegmentalanatomyinamurinemodel
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Liver lymphatic drainage patterns follow segmental anatomy in a murine model

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