Epidemiology and infection control of carbapenem resistant Acinetobacter baumannii and Klebsiella pneumoniae at a German university hospital: a retrospective study of 5 years (2015–2019)

Abstract Background Carbapenem resistant (CR) Klebsiella pneumoniae (Kp) and Acinetobacter baumannii (Ab) are emerging multidrug resistant bacteria with very limited treatment options in case of infection. Both are well-known causes of nosocomial infections and outbreaks in healthcare facilities. Me...

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Autores principales:	Patrick Chhatwal, Ella Ebadi, Frank Schwab, Stefan Ziesing, Ralf-Peter Vonberg, Nicolas Simon, Svetlana Gerbel, Dirk Schlüter, Franz-Christoph Bange, Claas Baier
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Acinetobacter baumannii Klebsiella pneumoniae Carbapenem resistant Infection control Epidemiology Screening Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/83ac978e9ad04e24b1f306b2ff6cd5e5
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spelling	oai:doaj.org-article:83ac978e9ad04e24b1f306b2ff6cd5e52021-11-28T12:41:52ZEpidemiology and infection control of carbapenem resistant Acinetobacter baumannii and Klebsiella pneumoniae at a German university hospital: a retrospective study of 5 years (2015–2019)10.1186/s12879-021-06900-31471-2334https://doaj.org/article/83ac978e9ad04e24b1f306b2ff6cd5e52021-11-01T00:00:00Zhttps://doi.org/10.1186/s12879-021-06900-3https://doaj.org/toc/1471-2334Abstract Background Carbapenem resistant (CR) Klebsiella pneumoniae (Kp) and Acinetobacter baumannii (Ab) are emerging multidrug resistant bacteria with very limited treatment options in case of infection. Both are well-known causes of nosocomial infections and outbreaks in healthcare facilities. Methods A retrospective study was conducted to investigate the epidemiology of inpatients with CR Kp and CR Ab in a 1500-bed German university hospital from 2015 to 2019. We present our infection control concept including a weekly microbiologic screening for patients who shared the ward with a CR Kp or CR Ab index patient. Results Within 5 years, 141 CR Kp and 60 CR Ab cases were hospitalized corresponding to 118 unique patients (74 patients with CR Kp, 39 patients with CR Ab and 5 patients with both CR Ab and CR Kp). The mean incidence was 0.045 (CR Kp) and 0.019 (CR Ab) per 100 inpatient cases, respectively. Nosocomial acquisition occurred in 53 cases (37.6%) of the CR Kp group and in 12 cases (20.0%) of the CR Ab group. Clinical infection occurred in 24 cases (17.0%) of the CR Kp group and in 21 cases (35.0%) of the CR Ab group. 14 cases (9.9%) of the CR Kp group and 29 cases (48.3%) of the CR Ab group had a history of a hospital stay abroad within 12 months prior to admission to our hospital. The weekly microbiologic screening revealed 4 CR Kp cases caused by nosocomial transmission that would have been missed without repetitive screening. Conclusions CR Kp and CR Ab cases occurred infrequently. A history of a hospital stay abroad, particularly in the CR Ab group, warrants pre-emptive infection control measures. The weekly microbiologic screening needs further evaluation in terms of its efficiency.Patrick ChhatwalElla EbadiFrank SchwabStefan ZiesingRalf-Peter VonbergNicolas SimonSvetlana GerbelDirk SchlüterFranz-Christoph BangeClaas BaierBMCarticleAcinetobacter baumanniiKlebsiella pneumoniaeCarbapenem resistantInfection controlEpidemiologyScreeningInfectious and parasitic diseasesRC109-216ENBMC Infectious Diseases, Vol 21, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Acinetobacter baumannii Klebsiella pneumoniae Carbapenem resistant Infection control Epidemiology Screening Infectious and parasitic diseases RC109-216
spellingShingle	Acinetobacter baumannii Klebsiella pneumoniae Carbapenem resistant Infection control Epidemiology Screening Infectious and parasitic diseases RC109-216 Patrick Chhatwal Ella Ebadi Frank Schwab Stefan Ziesing Ralf-Peter Vonberg Nicolas Simon Svetlana Gerbel Dirk Schlüter Franz-Christoph Bange Claas Baier Epidemiology and infection control of carbapenem resistant Acinetobacter baumannii and Klebsiella pneumoniae at a German university hospital: a retrospective study of 5 years (2015–2019)
description	Abstract Background Carbapenem resistant (CR) Klebsiella pneumoniae (Kp) and Acinetobacter baumannii (Ab) are emerging multidrug resistant bacteria with very limited treatment options in case of infection. Both are well-known causes of nosocomial infections and outbreaks in healthcare facilities. Methods A retrospective study was conducted to investigate the epidemiology of inpatients with CR Kp and CR Ab in a 1500-bed German university hospital from 2015 to 2019. We present our infection control concept including a weekly microbiologic screening for patients who shared the ward with a CR Kp or CR Ab index patient. Results Within 5 years, 141 CR Kp and 60 CR Ab cases were hospitalized corresponding to 118 unique patients (74 patients with CR Kp, 39 patients with CR Ab and 5 patients with both CR Ab and CR Kp). The mean incidence was 0.045 (CR Kp) and 0.019 (CR Ab) per 100 inpatient cases, respectively. Nosocomial acquisition occurred in 53 cases (37.6%) of the CR Kp group and in 12 cases (20.0%) of the CR Ab group. Clinical infection occurred in 24 cases (17.0%) of the CR Kp group and in 21 cases (35.0%) of the CR Ab group. 14 cases (9.9%) of the CR Kp group and 29 cases (48.3%) of the CR Ab group had a history of a hospital stay abroad within 12 months prior to admission to our hospital. The weekly microbiologic screening revealed 4 CR Kp cases caused by nosocomial transmission that would have been missed without repetitive screening. Conclusions CR Kp and CR Ab cases occurred infrequently. A history of a hospital stay abroad, particularly in the CR Ab group, warrants pre-emptive infection control measures. The weekly microbiologic screening needs further evaluation in terms of its efficiency.
format	article
author	Patrick Chhatwal Ella Ebadi Frank Schwab Stefan Ziesing Ralf-Peter Vonberg Nicolas Simon Svetlana Gerbel Dirk Schlüter Franz-Christoph Bange Claas Baier
author_facet	Patrick Chhatwal Ella Ebadi Frank Schwab Stefan Ziesing Ralf-Peter Vonberg Nicolas Simon Svetlana Gerbel Dirk Schlüter Franz-Christoph Bange Claas Baier
author_sort	Patrick Chhatwal
title	Epidemiology and infection control of carbapenem resistant Acinetobacter baumannii and Klebsiella pneumoniae at a German university hospital: a retrospective study of 5 years (2015–2019)
title_short	Epidemiology and infection control of carbapenem resistant Acinetobacter baumannii and Klebsiella pneumoniae at a German university hospital: a retrospective study of 5 years (2015–2019)
title_full	Epidemiology and infection control of carbapenem resistant Acinetobacter baumannii and Klebsiella pneumoniae at a German university hospital: a retrospective study of 5 years (2015–2019)
title_fullStr	Epidemiology and infection control of carbapenem resistant Acinetobacter baumannii and Klebsiella pneumoniae at a German university hospital: a retrospective study of 5 years (2015–2019)
title_full_unstemmed	Epidemiology and infection control of carbapenem resistant Acinetobacter baumannii and Klebsiella pneumoniae at a German university hospital: a retrospective study of 5 years (2015–2019)
title_sort	epidemiology and infection control of carbapenem resistant acinetobacter baumannii and klebsiella pneumoniae at a german university hospital: a retrospective study of 5 years (2015–2019)
publisher	BMC
publishDate	2021
url	https://doaj.org/article/83ac978e9ad04e24b1f306b2ff6cd5e5
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Epidemiology and infection control of carbapenem resistant Acinetobacter baumannii and Klebsiella pneumoniae at a German university hospital: a retrospective study of 5 years (2015–2019)

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