Crystal structure elucidation and anticancer studies of (-)-pseudosemiglabrin: a flavanone isolated from the aerial parts of Tephrosia apollinea.

Tephrosia apollinea is a perennial shrublet widely distributed in Africa and is known to have medicinal properties. The current study describes the bio-assay (cytotoxicity) guided isolation of (-)-pseudosemiglabrin from the aerial parts of T. apollinea. The structural and stereochemical features hav...

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Autores principales:	Loiy Elsir Ahmed Hassan, Mohamed B Khadeer Ahamed, Aman Shah Abdul Majid, Muhammad Adnan Iqbal, Fouad Saleih R Al Suede, Rosenani A Haque, Zhari Ismail, Oon Chern Ein, Amin Malik Shah Abdul Majid
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/83acc6739af648c2a20812b829fcb416
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spelling	oai:doaj.org-article:83acc6739af648c2a20812b829fcb4162021-11-18T08:29:11ZCrystal structure elucidation and anticancer studies of (-)-pseudosemiglabrin: a flavanone isolated from the aerial parts of Tephrosia apollinea.1932-620310.1371/journal.pone.0090806https://doaj.org/article/83acc6739af648c2a20812b829fcb4162014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24608571/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Tephrosia apollinea is a perennial shrublet widely distributed in Africa and is known to have medicinal properties. The current study describes the bio-assay (cytotoxicity) guided isolation of (-)-pseudosemiglabrin from the aerial parts of T. apollinea. The structural and stereochemical features have been described using spectral and x-ray crystallographic techniques. The cytotoxicity of isolated compound was evaluated against nine cancer cell lines. In addition, human fibroblast was used as a model cell line for normal cells. The results showed that (-)-pseudosemiglabrin exhibited dose-dependent antiproliferative effect on most of the tested cancer cell lines. Selectively, the compound showed significant inhibitory effect on the proliferation of leukemia, prostate and breast cancer cell lines. Further studies revealed that, the compound exhibited proapoptotic phenomenon of cytotoxicity. Interestingly, the compound did not display toxicity against the normal human fibroblast. It can be concluded that (-)-pseudosemiglabrin is worthy for further investigation as a potential chemotherapeutic agent.Loiy Elsir Ahmed HassanMohamed B Khadeer AhamedAman Shah Abdul MajidMuhammad Adnan IqbalFouad Saleih R Al SuedeRosenani A HaqueZhari IsmailOon Chern EinAmin Malik Shah Abdul MajidPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e90806 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Loiy Elsir Ahmed Hassan Mohamed B Khadeer Ahamed Aman Shah Abdul Majid Muhammad Adnan Iqbal Fouad Saleih R Al Suede Rosenani A Haque Zhari Ismail Oon Chern Ein Amin Malik Shah Abdul Majid Crystal structure elucidation and anticancer studies of (-)-pseudosemiglabrin: a flavanone isolated from the aerial parts of Tephrosia apollinea.
description	Tephrosia apollinea is a perennial shrublet widely distributed in Africa and is known to have medicinal properties. The current study describes the bio-assay (cytotoxicity) guided isolation of (-)-pseudosemiglabrin from the aerial parts of T. apollinea. The structural and stereochemical features have been described using spectral and x-ray crystallographic techniques. The cytotoxicity of isolated compound was evaluated against nine cancer cell lines. In addition, human fibroblast was used as a model cell line for normal cells. The results showed that (-)-pseudosemiglabrin exhibited dose-dependent antiproliferative effect on most of the tested cancer cell lines. Selectively, the compound showed significant inhibitory effect on the proliferation of leukemia, prostate and breast cancer cell lines. Further studies revealed that, the compound exhibited proapoptotic phenomenon of cytotoxicity. Interestingly, the compound did not display toxicity against the normal human fibroblast. It can be concluded that (-)-pseudosemiglabrin is worthy for further investigation as a potential chemotherapeutic agent.
format	article
author	Loiy Elsir Ahmed Hassan Mohamed B Khadeer Ahamed Aman Shah Abdul Majid Muhammad Adnan Iqbal Fouad Saleih R Al Suede Rosenani A Haque Zhari Ismail Oon Chern Ein Amin Malik Shah Abdul Majid
author_facet	Loiy Elsir Ahmed Hassan Mohamed B Khadeer Ahamed Aman Shah Abdul Majid Muhammad Adnan Iqbal Fouad Saleih R Al Suede Rosenani A Haque Zhari Ismail Oon Chern Ein Amin Malik Shah Abdul Majid
author_sort	Loiy Elsir Ahmed Hassan
title	Crystal structure elucidation and anticancer studies of (-)-pseudosemiglabrin: a flavanone isolated from the aerial parts of Tephrosia apollinea.
title_short	Crystal structure elucidation and anticancer studies of (-)-pseudosemiglabrin: a flavanone isolated from the aerial parts of Tephrosia apollinea.
title_full	Crystal structure elucidation and anticancer studies of (-)-pseudosemiglabrin: a flavanone isolated from the aerial parts of Tephrosia apollinea.
title_fullStr	Crystal structure elucidation and anticancer studies of (-)-pseudosemiglabrin: a flavanone isolated from the aerial parts of Tephrosia apollinea.
title_full_unstemmed	Crystal structure elucidation and anticancer studies of (-)-pseudosemiglabrin: a flavanone isolated from the aerial parts of Tephrosia apollinea.
title_sort	crystal structure elucidation and anticancer studies of (-)-pseudosemiglabrin: a flavanone isolated from the aerial parts of tephrosia apollinea.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/83acc6739af648c2a20812b829fcb416
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Crystal structure elucidation and anticancer studies of (-)-pseudosemiglabrin: a flavanone isolated from the aerial parts of Tephrosia apollinea.

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