Surface bioactivation through the nanostructured layer on titanium modified by facile HPT treatment

Abstract Facile fabrication of nanostructured surface is of great importance for the use of titanium (Ti) implants in biomedical field. In this study, a low-cost and easy-to-operate method called HPT (hydrothermal & pressure) here has been developed and used to fabricate the expected nanostructu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zhijun Guo, Nan Jiang, Chen Chen, Songsong Zhu, Li Zhang, Yubao Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/83b3a004c26d47239eeabbc5947275c5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:83b3a004c26d47239eeabbc5947275c5
record_format	dspace
spelling	oai:doaj.org-article:83b3a004c26d47239eeabbc5947275c52021-12-02T16:07:49ZSurface bioactivation through the nanostructured layer on titanium modified by facile HPT treatment10.1038/s41598-017-04395-02045-2322https://doaj.org/article/83b3a004c26d47239eeabbc5947275c52017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04395-0https://doaj.org/toc/2045-2322Abstract Facile fabrication of nanostructured surface is of great importance for the use of titanium (Ti) implants in biomedical field. In this study, a low-cost and easy-to-operate method called HPT (hydrothermal & pressure) here has been developed and used to fabricate the expected nanostructured surface on Ti substrates. The effects of experimental parameters on the morphology of Ti surface were investigated and characterized. The results indicated that by altering the hydrothermal pressure, NaOH concentration and treating time, surface nanostructure like nanopetals or nanoflakes could be formed on the surface of Ti substrates. The orthogonal experiments were conducted to demonstrate the optimized operation conditions. A formation mechanism of the nanostructured titanate layer was proposed, revealing that the nanostructured layer could be formed via a special upward and downward co-growth manner. In vitro cell culture showed that the HPT treated Ti substrates, especially the T-10 sample, could greatly enhance the cell-material interactions, i.e. the cell proliferation and differentiation, focal protein adhesion, and osteogenic factor expression. The HPT method paves a new way to modify the surface of Ti implants with better bioactivity and promising prospect for future biomedical applications.Zhijun GuoNan JiangChen ChenSongsong ZhuLi ZhangYubao LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhijun Guo Nan Jiang Chen Chen Songsong Zhu Li Zhang Yubao Li Surface bioactivation through the nanostructured layer on titanium modified by facile HPT treatment
description	Abstract Facile fabrication of nanostructured surface is of great importance for the use of titanium (Ti) implants in biomedical field. In this study, a low-cost and easy-to-operate method called HPT (hydrothermal & pressure) here has been developed and used to fabricate the expected nanostructured surface on Ti substrates. The effects of experimental parameters on the morphology of Ti surface were investigated and characterized. The results indicated that by altering the hydrothermal pressure, NaOH concentration and treating time, surface nanostructure like nanopetals or nanoflakes could be formed on the surface of Ti substrates. The orthogonal experiments were conducted to demonstrate the optimized operation conditions. A formation mechanism of the nanostructured titanate layer was proposed, revealing that the nanostructured layer could be formed via a special upward and downward co-growth manner. In vitro cell culture showed that the HPT treated Ti substrates, especially the T-10 sample, could greatly enhance the cell-material interactions, i.e. the cell proliferation and differentiation, focal protein adhesion, and osteogenic factor expression. The HPT method paves a new way to modify the surface of Ti implants with better bioactivity and promising prospect for future biomedical applications.
format	article
author	Zhijun Guo Nan Jiang Chen Chen Songsong Zhu Li Zhang Yubao Li
author_facet	Zhijun Guo Nan Jiang Chen Chen Songsong Zhu Li Zhang Yubao Li
author_sort	Zhijun Guo
title	Surface bioactivation through the nanostructured layer on titanium modified by facile HPT treatment
title_short	Surface bioactivation through the nanostructured layer on titanium modified by facile HPT treatment
title_full	Surface bioactivation through the nanostructured layer on titanium modified by facile HPT treatment
title_fullStr	Surface bioactivation through the nanostructured layer on titanium modified by facile HPT treatment
title_full_unstemmed	Surface bioactivation through the nanostructured layer on titanium modified by facile HPT treatment
title_sort	surface bioactivation through the nanostructured layer on titanium modified by facile hpt treatment
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/83b3a004c26d47239eeabbc5947275c5
work_keys_str_mv	AT zhijunguo surfacebioactivationthroughthenanostructuredlayerontitaniummodifiedbyfacilehpttreatment AT nanjiang surfacebioactivationthroughthenanostructuredlayerontitaniummodifiedbyfacilehpttreatment AT chenchen surfacebioactivationthroughthenanostructuredlayerontitaniummodifiedbyfacilehpttreatment AT songsongzhu surfacebioactivationthroughthenanostructuredlayerontitaniummodifiedbyfacilehpttreatment AT lizhang surfacebioactivationthroughthenanostructuredlayerontitaniummodifiedbyfacilehpttreatment AT yubaoli surfacebioactivationthroughthenanostructuredlayerontitaniummodifiedbyfacilehpttreatment
_version_	1718384727824531456

Surface bioactivation through the nanostructured layer on titanium modified by facile HPT treatment

Ejemplares similares