High levels of drug resistance in commensal E. coli in a cohort of children from rural central India

Abstract The world is experiencing crisis of antibiotic resistance not only in pathogenic but also in commensal bacteria. We determine the prevalence of antibiotic resistance in commensal Escherichia coli in young children in rural setting of central India and search for its correlations with demogr...

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Autores principales:	Manju Raj Purohit, Lars Falkdalen Lindahl, Vishal Diwan, Gaetano Marrone, Cecilia Stålsby Lundborg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/83b67c192ee0415180a84c831cbe0a91
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spelling	oai:doaj.org-article:83b67c192ee0415180a84c831cbe0a912021-12-02T15:09:54ZHigh levels of drug resistance in commensal E. coli in a cohort of children from rural central India10.1038/s41598-019-43227-12045-2322https://doaj.org/article/83b67c192ee0415180a84c831cbe0a912019-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-43227-1https://doaj.org/toc/2045-2322Abstract The world is experiencing crisis of antibiotic resistance not only in pathogenic but also in commensal bacteria. We determine the prevalence of antibiotic resistance in commensal Escherichia coli in young children in rural setting of central India and search for its correlations with demographic and behavioral factors. At seven time points during a period of 2 years we collected stool samples from 125 children; aged 1–3 in a rural area of Madhya Pradesh. We isolated six isolates of E. coli per stool sample and subjected them to antibiotic susceptibility testing. We found resistance to ampicillin, quinolones, cephalosporins, sulfamethoxazole, co-trimoxazole, in at least one isolate from 89% to 100% of children. Extended spectrum beta lactamase producing E. coli were identified in all but one child and multidrug resistance was identified in isolates from all children. Female gender (p = 0.04) and higher wealth (p = 0.03) was significantly correlated with less antibiotic resistance. Thus, the high prevalence of antibiotic resistance in commensal E. coli in rural community from India needs urgent measures to control the growing antibiotic resistance crisis.Manju Raj PurohitLars Falkdalen LindahlVishal DiwanGaetano MarroneCecilia Stålsby LundborgNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Manju Raj Purohit Lars Falkdalen Lindahl Vishal Diwan Gaetano Marrone Cecilia Stålsby Lundborg High levels of drug resistance in commensal E. coli in a cohort of children from rural central India
description	Abstract The world is experiencing crisis of antibiotic resistance not only in pathogenic but also in commensal bacteria. We determine the prevalence of antibiotic resistance in commensal Escherichia coli in young children in rural setting of central India and search for its correlations with demographic and behavioral factors. At seven time points during a period of 2 years we collected stool samples from 125 children; aged 1–3 in a rural area of Madhya Pradesh. We isolated six isolates of E. coli per stool sample and subjected them to antibiotic susceptibility testing. We found resistance to ampicillin, quinolones, cephalosporins, sulfamethoxazole, co-trimoxazole, in at least one isolate from 89% to 100% of children. Extended spectrum beta lactamase producing E. coli were identified in all but one child and multidrug resistance was identified in isolates from all children. Female gender (p = 0.04) and higher wealth (p = 0.03) was significantly correlated with less antibiotic resistance. Thus, the high prevalence of antibiotic resistance in commensal E. coli in rural community from India needs urgent measures to control the growing antibiotic resistance crisis.
format	article
author	Manju Raj Purohit Lars Falkdalen Lindahl Vishal Diwan Gaetano Marrone Cecilia Stålsby Lundborg
author_facet	Manju Raj Purohit Lars Falkdalen Lindahl Vishal Diwan Gaetano Marrone Cecilia Stålsby Lundborg
author_sort	Manju Raj Purohit
title	High levels of drug resistance in commensal E. coli in a cohort of children from rural central India
title_short	High levels of drug resistance in commensal E. coli in a cohort of children from rural central India
title_full	High levels of drug resistance in commensal E. coli in a cohort of children from rural central India
title_fullStr	High levels of drug resistance in commensal E. coli in a cohort of children from rural central India
title_full_unstemmed	High levels of drug resistance in commensal E. coli in a cohort of children from rural central India
title_sort	high levels of drug resistance in commensal e. coli in a cohort of children from rural central india
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/83b67c192ee0415180a84c831cbe0a91
work_keys_str_mv	AT manjurajpurohit highlevelsofdrugresistanceincommensalecoliinacohortofchildrenfromruralcentralindia AT larsfalkdalenlindahl highlevelsofdrugresistanceincommensalecoliinacohortofchildrenfromruralcentralindia AT vishaldiwan highlevelsofdrugresistanceincommensalecoliinacohortofchildrenfromruralcentralindia AT gaetanomarrone highlevelsofdrugresistanceincommensalecoliinacohortofchildrenfromruralcentralindia AT ceciliastalsbylundborg highlevelsofdrugresistanceincommensalecoliinacohortofchildrenfromruralcentralindia
_version_	1718387762859606016

High levels of drug resistance in commensal E. coli in a cohort of children from rural central India

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