Comprehensive molecular characterization of pediatric radiation-induced high-grade glioma
Radiation-induced high-grade gliomas (RIGs) are an incurable late complication of cranial radiation therapy. In the largest study to date, we report the results of DNA methylation profiling, RNA-Seq and genomic sequencing of 32 RIG tumors, and an in vitro drug screen in two RIG cell lines.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/83b97f7c6e28476688641217970f4a3f |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:83b97f7c6e28476688641217970f4a3f |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:83b97f7c6e28476688641217970f4a3f2021-12-02T18:14:16ZComprehensive molecular characterization of pediatric radiation-induced high-grade glioma10.1038/s41467-021-25709-x2041-1723https://doaj.org/article/83b97f7c6e28476688641217970f4a3f2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25709-xhttps://doaj.org/toc/2041-1723Radiation-induced high-grade gliomas (RIGs) are an incurable late complication of cranial radiation therapy. In the largest study to date, we report the results of DNA methylation profiling, RNA-Seq and genomic sequencing of 32 RIG tumors, and an in vitro drug screen in two RIG cell lines.John DeSistoJohn T. LucasKe XuAndrew DonsonTong LinBridget SanfordGang WuQuynh T. TranDale HedgesChih-Yang HsuGregory T. ArmstrongMichael ArnoldSmita BhatiaPatrick FlanneryRakeb LemmaLakotah HardieUlrich SchüllerSujatha VenkataramanLindsey M. HoffmanKathleen DorrisJean M. Mulcahy LevyTodd C. HankinsonMichael HandlerArthur K. LiuNicholas ForemanRajeev VibhakarKenneth JonesSariah AllenJinghui ZhangSuzanne J. BakerThomas E. MerchantBrent A. OrrAdam L. GreenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q John DeSisto John T. Lucas Ke Xu Andrew Donson Tong Lin Bridget Sanford Gang Wu Quynh T. Tran Dale Hedges Chih-Yang Hsu Gregory T. Armstrong Michael Arnold Smita Bhatia Patrick Flannery Rakeb Lemma Lakotah Hardie Ulrich Schüller Sujatha Venkataraman Lindsey M. Hoffman Kathleen Dorris Jean M. Mulcahy Levy Todd C. Hankinson Michael Handler Arthur K. Liu Nicholas Foreman Rajeev Vibhakar Kenneth Jones Sariah Allen Jinghui Zhang Suzanne J. Baker Thomas E. Merchant Brent A. Orr Adam L. Green Comprehensive molecular characterization of pediatric radiation-induced high-grade glioma |
| description |
Radiation-induced high-grade gliomas (RIGs) are an incurable late complication of cranial radiation therapy. In the largest study to date, we report the results of DNA methylation profiling, RNA-Seq and genomic sequencing of 32 RIG tumors, and an in vitro drug screen in two RIG cell lines. |
| format |
article |
| author |
John DeSisto John T. Lucas Ke Xu Andrew Donson Tong Lin Bridget Sanford Gang Wu Quynh T. Tran Dale Hedges Chih-Yang Hsu Gregory T. Armstrong Michael Arnold Smita Bhatia Patrick Flannery Rakeb Lemma Lakotah Hardie Ulrich Schüller Sujatha Venkataraman Lindsey M. Hoffman Kathleen Dorris Jean M. Mulcahy Levy Todd C. Hankinson Michael Handler Arthur K. Liu Nicholas Foreman Rajeev Vibhakar Kenneth Jones Sariah Allen Jinghui Zhang Suzanne J. Baker Thomas E. Merchant Brent A. Orr Adam L. Green |
| author_facet |
John DeSisto John T. Lucas Ke Xu Andrew Donson Tong Lin Bridget Sanford Gang Wu Quynh T. Tran Dale Hedges Chih-Yang Hsu Gregory T. Armstrong Michael Arnold Smita Bhatia Patrick Flannery Rakeb Lemma Lakotah Hardie Ulrich Schüller Sujatha Venkataraman Lindsey M. Hoffman Kathleen Dorris Jean M. Mulcahy Levy Todd C. Hankinson Michael Handler Arthur K. Liu Nicholas Foreman Rajeev Vibhakar Kenneth Jones Sariah Allen Jinghui Zhang Suzanne J. Baker Thomas E. Merchant Brent A. Orr Adam L. Green |
| author_sort |
John DeSisto |
| title |
Comprehensive molecular characterization of pediatric radiation-induced high-grade glioma |
| title_short |
Comprehensive molecular characterization of pediatric radiation-induced high-grade glioma |
| title_full |
Comprehensive molecular characterization of pediatric radiation-induced high-grade glioma |
| title_fullStr |
Comprehensive molecular characterization of pediatric radiation-induced high-grade glioma |
| title_full_unstemmed |
Comprehensive molecular characterization of pediatric radiation-induced high-grade glioma |
| title_sort |
comprehensive molecular characterization of pediatric radiation-induced high-grade glioma |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/83b97f7c6e28476688641217970f4a3f |
| work_keys_str_mv |
AT johndesisto comprehensivemolecularcharacterizationofpediatricradiationinducedhighgradeglioma AT johntlucas comprehensivemolecularcharacterizationofpediatricradiationinducedhighgradeglioma AT kexu comprehensivemolecularcharacterizationofpediatricradiationinducedhighgradeglioma AT andrewdonson comprehensivemolecularcharacterizationofpediatricradiationinducedhighgradeglioma AT tonglin comprehensivemolecularcharacterizationofpediatricradiationinducedhighgradeglioma AT bridgetsanford comprehensivemolecularcharacterizationofpediatricradiationinducedhighgradeglioma AT gangwu comprehensivemolecularcharacterizationofpediatricradiationinducedhighgradeglioma AT quynhttran comprehensivemolecularcharacterizationofpediatricradiationinducedhighgradeglioma AT dalehedges comprehensivemolecularcharacterizationofpediatricradiationinducedhighgradeglioma AT chihyanghsu comprehensivemolecularcharacterizationofpediatricradiationinducedhighgradeglioma AT gregorytarmstrong comprehensivemolecularcharacterizationofpediatricradiationinducedhighgradeglioma AT michaelarnold comprehensivemolecularcharacterizationofpediatricradiationinducedhighgradeglioma AT smitabhatia comprehensivemolecularcharacterizationofpediatricradiationinducedhighgradeglioma AT patrickflannery comprehensivemolecularcharacterizationofpediatricradiationinducedhighgradeglioma AT rakeblemma comprehensivemolecularcharacterizationofpediatricradiationinducedhighgradeglioma AT lakotahhardie comprehensivemolecularcharacterizationofpediatricradiationinducedhighgradeglioma AT ulrichschuller comprehensivemolecularcharacterizationofpediatricradiationinducedhighgradeglioma AT sujathavenkataraman comprehensivemolecularcharacterizationofpediatricradiationinducedhighgradeglioma AT lindseymhoffman comprehensivemolecularcharacterizationofpediatricradiationinducedhighgradeglioma AT kathleendorris comprehensivemolecularcharacterizationofpediatricradiationinducedhighgradeglioma AT jeanmmulcahylevy comprehensivemolecularcharacterizationofpediatricradiationinducedhighgradeglioma AT toddchankinson comprehensivemolecularcharacterizationofpediatricradiationinducedhighgradeglioma AT michaelhandler comprehensivemolecularcharacterizationofpediatricradiationinducedhighgradeglioma AT arthurkliu comprehensivemolecularcharacterizationofpediatricradiationinducedhighgradeglioma AT nicholasforeman comprehensivemolecularcharacterizationofpediatricradiationinducedhighgradeglioma AT rajeevvibhakar comprehensivemolecularcharacterizationofpediatricradiationinducedhighgradeglioma AT kennethjones comprehensivemolecularcharacterizationofpediatricradiationinducedhighgradeglioma AT sariahallen comprehensivemolecularcharacterizationofpediatricradiationinducedhighgradeglioma AT jinghuizhang comprehensivemolecularcharacterizationofpediatricradiationinducedhighgradeglioma AT suzannejbaker comprehensivemolecularcharacterizationofpediatricradiationinducedhighgradeglioma AT thomasemerchant comprehensivemolecularcharacterizationofpediatricradiationinducedhighgradeglioma AT brentaorr comprehensivemolecularcharacterizationofpediatricradiationinducedhighgradeglioma AT adamlgreen comprehensivemolecularcharacterizationofpediatricradiationinducedhighgradeglioma |
| _version_ |
1718378403983261696 |