Comprehensive molecular characterization of pediatric radiation-induced high-grade glioma

Comprehensive molecular characterization of pediatric radiation-induced high-grade glioma

Radiation-induced high-grade gliomas (RIGs) are an incurable late complication of cranial radiation therapy. In the largest study to date, we report the results of DNA methylation profiling, RNA-Seq and genomic sequencing of 32 RIG tumors, and an in vitro drug screen in two RIG cell lines.

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Bibliographic Details
Main Authors: John DeSisto, John T. Lucas, Ke Xu, Andrew Donson, Tong Lin, Bridget Sanford, Gang Wu, Quynh T. Tran, Dale Hedges, Chih-Yang Hsu, Gregory T. Armstrong, Michael Arnold, Smita Bhatia, Patrick Flannery, Rakeb Lemma, Lakotah Hardie, Ulrich Schüller, Sujatha Venkataraman, Lindsey M. Hoffman, Kathleen Dorris, Jean M. Mulcahy Levy, Todd C. Hankinson, Michael Handler, Arthur K. Liu, Nicholas Foreman, Rajeev Vibhakar, Kenneth Jones, Sariah Allen, Jinghui Zhang, Suzanne J. Baker, Thomas E. Merchant, Brent A. Orr, Adam L. Green
Format: article
Language:EN
Published: Nature Portfolio 2021
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Science
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Online Access:https://doaj.org/article/83b97f7c6e28476688641217970f4a3f
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