Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists

Toll-like receptor 8 (TLR8) plays essential roles in the innate immune response to viral single-stranded RNA (ssRNA), so small molecule modulators of TLR8 are of interest, however adverse effects limit their use. Here, the authors report a tetrasubstituted imidazole CU-CPD107 with dichotomous behavi...

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Autores principales:	Yi Yang, Adam Csakai, Shuangshuang Jiang, Christina Smith, Hiromi Tanji, Jian Huang, Torey Jones, Kentaro Sakaniwa, Lindsey Broadwell, Chengrui Shi, Subada Soti, Umeharu Ohto, Yaohui Fang, Shu Shen, Fei Deng, Toshiyuki Shimizu, Hang Yin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/83bd70c8f89a49098e079e0d211e760d
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spelling	oai:doaj.org-article:83bd70c8f89a49098e079e0d211e760d2021-12-02T16:08:13ZTetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists10.1038/s41467-021-24536-42041-1723https://doaj.org/article/83bd70c8f89a49098e079e0d211e760d2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24536-4https://doaj.org/toc/2041-1723Toll-like receptor 8 (TLR8) plays essential roles in the innate immune response to viral single-stranded RNA (ssRNA), so small molecule modulators of TLR8 are of interest, however adverse effects limit their use. Here, the authors report a tetrasubstituted imidazole CU-CPD107 with dichotomous behaviour, which inhibits R848-induced TLR8 signaling, but shows synergistic activity in the presence of ssRNA, making it a potential antiviral agent.Yi YangAdam CsakaiShuangshuang JiangChristina SmithHiromi TanjiJian HuangTorey JonesKentaro SakaniwaLindsey BroadwellChengrui ShiSubada SotiUmeharu OhtoYaohui FangShu ShenFei DengToshiyuki ShimizuHang YinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yi Yang Adam Csakai Shuangshuang Jiang Christina Smith Hiromi Tanji Jian Huang Torey Jones Kentaro Sakaniwa Lindsey Broadwell Chengrui Shi Subada Soti Umeharu Ohto Yaohui Fang Shu Shen Fei Deng Toshiyuki Shimizu Hang Yin Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists
description	Toll-like receptor 8 (TLR8) plays essential roles in the innate immune response to viral single-stranded RNA (ssRNA), so small molecule modulators of TLR8 are of interest, however adverse effects limit their use. Here, the authors report a tetrasubstituted imidazole CU-CPD107 with dichotomous behaviour, which inhibits R848-induced TLR8 signaling, but shows synergistic activity in the presence of ssRNA, making it a potential antiviral agent.
format	article
author	Yi Yang Adam Csakai Shuangshuang Jiang Christina Smith Hiromi Tanji Jian Huang Torey Jones Kentaro Sakaniwa Lindsey Broadwell Chengrui Shi Subada Soti Umeharu Ohto Yaohui Fang Shu Shen Fei Deng Toshiyuki Shimizu Hang Yin
author_facet	Yi Yang Adam Csakai Shuangshuang Jiang Christina Smith Hiromi Tanji Jian Huang Torey Jones Kentaro Sakaniwa Lindsey Broadwell Chengrui Shi Subada Soti Umeharu Ohto Yaohui Fang Shu Shen Fei Deng Toshiyuki Shimizu Hang Yin
author_sort	Yi Yang
title	Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists
title_short	Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists
title_full	Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists
title_fullStr	Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists
title_full_unstemmed	Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists
title_sort	tetrasubstituted imidazoles as incognito toll-like receptor 8 a(nta)gonists
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/83bd70c8f89a49098e079e0d211e760d
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Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists

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