MOLECULAR MECHANISMS OF ENDOMETRIAL CARCINOMA

Molecular aspects of carcinogenesis of endometrium with analysis of scientific literature and own experimental data are considered. It was shown that in this process are involved as well classical signal transduction pathways like PI3K, Wnt, Bcl-2-regulated apoptosis as hormonal pathways from ERα to...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	L. F. Gulyaeva, S. E. Krasilnikov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2012
Materias:	erα bax cancer of endometrium signal transduction molecular markers apoptosis genes bcl-2 and bax angiogenesis genes il8 and mmps Science Q
Acceso en línea:	https://doaj.org/article/83beffc70ace41ac850890096270a2b1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:83beffc70ace41ac850890096270a2b1
record_format	dspace
spelling	oai:doaj.org-article:83beffc70ace41ac850890096270a2b12021-11-23T06:14:19ZMOLECULAR MECHANISMS OF ENDOMETRIAL CARCINOMA2541-94202587-9596https://doaj.org/article/83beffc70ace41ac850890096270a2b12012-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/869https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Molecular aspects of carcinogenesis of endometrium with analysis of scientific literature and own experimental data are considered. It was shown that in this process are involved as well classical signal transduction pathways like PI3K, Wnt, Bcl-2-regulated apoptosis as hormonal pathways from ERα to target genes. Gene expression of apoptosis inhibitor Bcl-2 was in 6 folds higher in malignant tumors in comparison with non cancer tissue. Expression level of ERα gene was higher in cancer tissue than in adjacent non-tumor endometrium. Matrix metallo-proteinases MMR-3, MMR-9 and angiogenesis gene Il-8 expressed mainly in malignant endometrial tissues, but not in non-cancer tissues that considers these genes as suitable candidates for the characteristic of endometrial carcinoma. Thus, Bcl-2, IL8, ERα and MMPs 2 proteins can be appropriate markers of endometrial carcinoma together with the members of PI3K- and Wnt-signal pathways like PTEN and β-catenin.L. F. GulyaevaS. E. KrasilnikovScientific Сentre for Family Health and Human Reproduction Problemsarticleerαbaxcancer of endometriumsignal transductionmolecular markerserαapoptosis genes bcl-2 and baxangiogenesis genes il8 and mmpsScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3(1), Pp 110-115 (2012)
institution	DOAJ
collection	DOAJ
language	RU
topic	erα bax cancer of endometrium signal transduction molecular markers erα apoptosis genes bcl-2 and bax angiogenesis genes il8 and mmps Science Q
spellingShingle	erα bax cancer of endometrium signal transduction molecular markers erα apoptosis genes bcl-2 and bax angiogenesis genes il8 and mmps Science Q L. F. Gulyaeva S. E. Krasilnikov MOLECULAR MECHANISMS OF ENDOMETRIAL CARCINOMA
description	Molecular aspects of carcinogenesis of endometrium with analysis of scientific literature and own experimental data are considered. It was shown that in this process are involved as well classical signal transduction pathways like PI3K, Wnt, Bcl-2-regulated apoptosis as hormonal pathways from ERα to target genes. Gene expression of apoptosis inhibitor Bcl-2 was in 6 folds higher in malignant tumors in comparison with non cancer tissue. Expression level of ERα gene was higher in cancer tissue than in adjacent non-tumor endometrium. Matrix metallo-proteinases MMR-3, MMR-9 and angiogenesis gene Il-8 expressed mainly in malignant endometrial tissues, but not in non-cancer tissues that considers these genes as suitable candidates for the characteristic of endometrial carcinoma. Thus, Bcl-2, IL8, ERα and MMPs 2 proteins can be appropriate markers of endometrial carcinoma together with the members of PI3K- and Wnt-signal pathways like PTEN and β-catenin.
format	article
author	L. F. Gulyaeva S. E. Krasilnikov
author_facet	L. F. Gulyaeva S. E. Krasilnikov
author_sort	L. F. Gulyaeva
title	MOLECULAR MECHANISMS OF ENDOMETRIAL CARCINOMA
title_short	MOLECULAR MECHANISMS OF ENDOMETRIAL CARCINOMA
title_full	MOLECULAR MECHANISMS OF ENDOMETRIAL CARCINOMA
title_fullStr	MOLECULAR MECHANISMS OF ENDOMETRIAL CARCINOMA
title_full_unstemmed	MOLECULAR MECHANISMS OF ENDOMETRIAL CARCINOMA
title_sort	molecular mechanisms of endometrial carcinoma
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2012
url	https://doaj.org/article/83beffc70ace41ac850890096270a2b1
work_keys_str_mv	AT lfgulyaeva molecularmechanismsofendometrialcarcinoma AT sekrasilnikov molecularmechanismsofendometrialcarcinoma
_version_	1718417330142183424

MOLECULAR MECHANISMS OF ENDOMETRIAL CARCINOMA

Ejemplares similares