Signal recognition particle prevents N-terminal processing of bacterial membrane proteins

Bacterial proteins are synthesized with formyl-methionine in their N-terminus, but most of them are co-translationally deformylated. Here, the authors show that inner-membrane proteins are protected from deformylation by the binding of the signal recognition particle (SRP) during translation.

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Autores principales:	Amitabh Ranjan, Evan Mercier, Arshiya Bhatt, Wolfgang Wintermeyer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/83c059c8a0f7497dbfaccb26be289684
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spelling	oai:doaj.org-article:83c059c8a0f7497dbfaccb26be2896842021-12-02T15:39:01ZSignal recognition particle prevents N-terminal processing of bacterial membrane proteins10.1038/ncomms155622041-1723https://doaj.org/article/83c059c8a0f7497dbfaccb26be2896842017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15562https://doaj.org/toc/2041-1723Bacterial proteins are synthesized with formyl-methionine in their N-terminus, but most of them are co-translationally deformylated. Here, the authors show that inner-membrane proteins are protected from deformylation by the binding of the signal recognition particle (SRP) during translation.Amitabh RanjanEvan MercierArshiya BhattWolfgang WintermeyerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amitabh Ranjan Evan Mercier Arshiya Bhatt Wolfgang Wintermeyer Signal recognition particle prevents N-terminal processing of bacterial membrane proteins
description	Bacterial proteins are synthesized with formyl-methionine in their N-terminus, but most of them are co-translationally deformylated. Here, the authors show that inner-membrane proteins are protected from deformylation by the binding of the signal recognition particle (SRP) during translation.
format	article
author	Amitabh Ranjan Evan Mercier Arshiya Bhatt Wolfgang Wintermeyer
author_facet	Amitabh Ranjan Evan Mercier Arshiya Bhatt Wolfgang Wintermeyer
author_sort	Amitabh Ranjan
title	Signal recognition particle prevents N-terminal processing of bacterial membrane proteins
title_short	Signal recognition particle prevents N-terminal processing of bacterial membrane proteins
title_full	Signal recognition particle prevents N-terminal processing of bacterial membrane proteins
title_fullStr	Signal recognition particle prevents N-terminal processing of bacterial membrane proteins
title_full_unstemmed	Signal recognition particle prevents N-terminal processing of bacterial membrane proteins
title_sort	signal recognition particle prevents n-terminal processing of bacterial membrane proteins
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/83c059c8a0f7497dbfaccb26be289684
work_keys_str_mv	AT amitabhranjan signalrecognitionparticlepreventsnterminalprocessingofbacterialmembraneproteins AT evanmercier signalrecognitionparticlepreventsnterminalprocessingofbacterialmembraneproteins AT arshiyabhatt signalrecognitionparticlepreventsnterminalprocessingofbacterialmembraneproteins AT wolfgangwintermeyer signalrecognitionparticlepreventsnterminalprocessingofbacterialmembraneproteins
_version_	1718385998956593152

Signal recognition particle prevents N-terminal processing of bacterial membrane proteins

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