Maternal and offspring high-fat diet leads to platelet hyperactivation in male mice offspring

Abstract Maternal over-nutrition increases the risk of diabetes and cardiovascular events in offspring. While prominent effects on cardiovascular health are observed, the impact on platelet physiology has not been studied. Here, we examined whether maternal high-fat diet (HF) ingestion affects the p...

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Autores principales:	Renato S. Gaspar, Amanda J. Unsworth, Alaa Al-Dibouni, Alexander P. Bye, Tanya Sage, Michelle Stewart, Sara Wells, Roger D. Cox, Jonathan M. Gibbins, Dyan Sellayah, Craig E. Hughes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/83c5d0fd5e654fdebe78e6a31fc980f1
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spelling	oai:doaj.org-article:83c5d0fd5e654fdebe78e6a31fc980f12021-12-02T14:01:23ZMaternal and offspring high-fat diet leads to platelet hyperactivation in male mice offspring10.1038/s41598-020-80373-32045-2322https://doaj.org/article/83c5d0fd5e654fdebe78e6a31fc980f12021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80373-3https://doaj.org/toc/2045-2322Abstract Maternal over-nutrition increases the risk of diabetes and cardiovascular events in offspring. While prominent effects on cardiovascular health are observed, the impact on platelet physiology has not been studied. Here, we examined whether maternal high-fat diet (HF) ingestion affects the platelet function in lean and obese offspring. C57BL6/N mice dams were given a HF or control (C) diet for 8 weeks before and during pregnancy. Male and female offspring received C or HF diets for 26 weeks. Experimental groups were: C/C, dam and offspring fed standard laboratory diet; C/HF dam fed standard laboratory diet and offspring fed HF diet; HF/C and HF/HF. Phenotypic and metabolic tests were performed and blood collected for platelet studies. Compared to C/C, offspring HF groups were obese, with fat accumulation, hyperglycaemia and insulin resistance. Female offspring did not present platelet hyperactivity, hence we focused on male offspring. Platelets from HF/HF mice were larger, hyperactive and presented oxidative stress when compared to C/C. Maternal and offspring HF diet results in platelet hyperactivation in male mouse offspring, suggesting a novel ‘double-hit’ effect.Renato S. GasparAmanda J. UnsworthAlaa Al-DibouniAlexander P. ByeTanya SageMichelle StewartSara WellsRoger D. CoxJonathan M. GibbinsDyan SellayahCraig E. HughesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Renato S. Gaspar Amanda J. Unsworth Alaa Al-Dibouni Alexander P. Bye Tanya Sage Michelle Stewart Sara Wells Roger D. Cox Jonathan M. Gibbins Dyan Sellayah Craig E. Hughes Maternal and offspring high-fat diet leads to platelet hyperactivation in male mice offspring
description	Abstract Maternal over-nutrition increases the risk of diabetes and cardiovascular events in offspring. While prominent effects on cardiovascular health are observed, the impact on platelet physiology has not been studied. Here, we examined whether maternal high-fat diet (HF) ingestion affects the platelet function in lean and obese offspring. C57BL6/N mice dams were given a HF or control (C) diet for 8 weeks before and during pregnancy. Male and female offspring received C or HF diets for 26 weeks. Experimental groups were: C/C, dam and offspring fed standard laboratory diet; C/HF dam fed standard laboratory diet and offspring fed HF diet; HF/C and HF/HF. Phenotypic and metabolic tests were performed and blood collected for platelet studies. Compared to C/C, offspring HF groups were obese, with fat accumulation, hyperglycaemia and insulin resistance. Female offspring did not present platelet hyperactivity, hence we focused on male offspring. Platelets from HF/HF mice were larger, hyperactive and presented oxidative stress when compared to C/C. Maternal and offspring HF diet results in platelet hyperactivation in male mouse offspring, suggesting a novel ‘double-hit’ effect.
format	article
author	Renato S. Gaspar Amanda J. Unsworth Alaa Al-Dibouni Alexander P. Bye Tanya Sage Michelle Stewart Sara Wells Roger D. Cox Jonathan M. Gibbins Dyan Sellayah Craig E. Hughes
author_facet	Renato S. Gaspar Amanda J. Unsworth Alaa Al-Dibouni Alexander P. Bye Tanya Sage Michelle Stewart Sara Wells Roger D. Cox Jonathan M. Gibbins Dyan Sellayah Craig E. Hughes
author_sort	Renato S. Gaspar
title	Maternal and offspring high-fat diet leads to platelet hyperactivation in male mice offspring
title_short	Maternal and offspring high-fat diet leads to platelet hyperactivation in male mice offspring
title_full	Maternal and offspring high-fat diet leads to platelet hyperactivation in male mice offspring
title_fullStr	Maternal and offspring high-fat diet leads to platelet hyperactivation in male mice offspring
title_full_unstemmed	Maternal and offspring high-fat diet leads to platelet hyperactivation in male mice offspring
title_sort	maternal and offspring high-fat diet leads to platelet hyperactivation in male mice offspring
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/83c5d0fd5e654fdebe78e6a31fc980f1
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Maternal and offspring high-fat diet leads to platelet hyperactivation in male mice offspring

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