Evaluation of radiation maculopathy after treatment of choroidal melanoma with ruthenium-106 using optical coherence tomography angiography

Abstract Background To assess the impact of brachytherapy on macular microvasculature utilizing optical coherence tomography angiography (OCTA) in treated choroidal melanoma. Methods In this retrospective observational case series, we reviewed the recorded data of the patients with unilateral extram...

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Autores principales:	Ali Torkashvand, Hamid Riazi-Esfahani, Fariba Ghassemi, Elias Khalili Pour, Babak Masoomian, Mohammad Zarei, Kaveh Fadakar, Mojtaba Arjmand, Fereshteh Tayebi, Leila Ekradi, Hamid Abrishami Moghaddam, Tahereh Mahmoudi, Reihaneh Daneshmand, Hooshang Faghihi
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Deep capillary plexus Foveal avascular zone (FAZ) Radiation maculopathy Radiation retinopathy Retina burnout Ruthenium-106 Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/83c7accdf7bb4de8a281d42ff98ed5bc
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spelling	oai:doaj.org-article:83c7accdf7bb4de8a281d42ff98ed5bc2021-11-08T11:19:28ZEvaluation of radiation maculopathy after treatment of choroidal melanoma with ruthenium-106 using optical coherence tomography angiography10.1186/s12886-021-02140-w1471-2415https://doaj.org/article/83c7accdf7bb4de8a281d42ff98ed5bc2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12886-021-02140-whttps://doaj.org/toc/1471-2415Abstract Background To assess the impact of brachytherapy on macular microvasculature utilizing optical coherence tomography angiography (OCTA) in treated choroidal melanoma. Methods In this retrospective observational case series, we reviewed the recorded data of the patients with unilateral extramacular choroidal melanoma treated with ruthenium − 106 (106Ru) plaque radiotherapy with a follow-up period of more than 6 months. Automatically measured OCTA retinal parameters were analysed after image processing. Results Thirty-one eyes of 31 patients with the mean age of 51.1 years were recruited. Six eyes had no radiation maculopathy (RM). From 25 eyes with RM, nine eyes (36%) revealed a burnout macular microvasculature with imperceptible vascular details. Twenty-one non-irradiated fellow eyes from the enrolled patients were considered as the control group. Foveal and optic disc radiation dose had the highest value to predict the burnout pattern (ROC, AUC: 0.763, 0.727). Superficial and deep foveal avascular zone (FAZ) were larger in irradiated eyes in comparison to non-irradiated fellow eyes (1629 μm2 vs. 428 μm2, P = 0.005; 1837 μm2 vs 268 μm2, P = 0.021; respectively). Foveal and parafoveal vascular area density (VAD) and vascular skeleton density (VSD) in both superficial and deep capillary plexus (SCP and DCP) were decreased in all irradiated eyes in comparison with non-irradiated fellow eyes (P < 0.001). Compared with non-irradiated fellow eyes, irradiated eyes without RM had significantly lower VAD and VSD at foveal and parafoveal DCP (all P < 0.02). However, these differences at SCP were not statistically significant. Conclusion The OCTA is a valuable tool for evaluating RM. Initial subclinical microvascular insult after 106Ru brachytherapy is more likely to occur in DCP. The deep FAZ area was identified as a more critical biomarker of BCVA than superficial FAZ in these patients.Ali TorkashvandHamid Riazi-EsfahaniFariba GhassemiElias Khalili PourBabak MasoomianMohammad ZareiKaveh FadakarMojtaba ArjmandFereshteh TayebiLeila EkradiHamid Abrishami MoghaddamTahereh MahmoudiReihaneh DaneshmandHooshang FaghihiBMCarticleDeep capillary plexusFoveal avascular zone (FAZ)Radiation maculopathyRadiation retinopathyRetina burnoutRuthenium-106OphthalmologyRE1-994ENBMC Ophthalmology, Vol 21, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Deep capillary plexus Foveal avascular zone (FAZ) Radiation maculopathy Radiation retinopathy Retina burnout Ruthenium-106 Ophthalmology RE1-994
spellingShingle	Deep capillary plexus Foveal avascular zone (FAZ) Radiation maculopathy Radiation retinopathy Retina burnout Ruthenium-106 Ophthalmology RE1-994 Ali Torkashvand Hamid Riazi-Esfahani Fariba Ghassemi Elias Khalili Pour Babak Masoomian Mohammad Zarei Kaveh Fadakar Mojtaba Arjmand Fereshteh Tayebi Leila Ekradi Hamid Abrishami Moghaddam Tahereh Mahmoudi Reihaneh Daneshmand Hooshang Faghihi Evaluation of radiation maculopathy after treatment of choroidal melanoma with ruthenium-106 using optical coherence tomography angiography
description	Abstract Background To assess the impact of brachytherapy on macular microvasculature utilizing optical coherence tomography angiography (OCTA) in treated choroidal melanoma. Methods In this retrospective observational case series, we reviewed the recorded data of the patients with unilateral extramacular choroidal melanoma treated with ruthenium − 106 (106Ru) plaque radiotherapy with a follow-up period of more than 6 months. Automatically measured OCTA retinal parameters were analysed after image processing. Results Thirty-one eyes of 31 patients with the mean age of 51.1 years were recruited. Six eyes had no radiation maculopathy (RM). From 25 eyes with RM, nine eyes (36%) revealed a burnout macular microvasculature with imperceptible vascular details. Twenty-one non-irradiated fellow eyes from the enrolled patients were considered as the control group. Foveal and optic disc radiation dose had the highest value to predict the burnout pattern (ROC, AUC: 0.763, 0.727). Superficial and deep foveal avascular zone (FAZ) were larger in irradiated eyes in comparison to non-irradiated fellow eyes (1629 μm2 vs. 428 μm2, P = 0.005; 1837 μm2 vs 268 μm2, P = 0.021; respectively). Foveal and parafoveal vascular area density (VAD) and vascular skeleton density (VSD) in both superficial and deep capillary plexus (SCP and DCP) were decreased in all irradiated eyes in comparison with non-irradiated fellow eyes (P < 0.001). Compared with non-irradiated fellow eyes, irradiated eyes without RM had significantly lower VAD and VSD at foveal and parafoveal DCP (all P < 0.02). However, these differences at SCP were not statistically significant. Conclusion The OCTA is a valuable tool for evaluating RM. Initial subclinical microvascular insult after 106Ru brachytherapy is more likely to occur in DCP. The deep FAZ area was identified as a more critical biomarker of BCVA than superficial FAZ in these patients.
format	article
author	Ali Torkashvand Hamid Riazi-Esfahani Fariba Ghassemi Elias Khalili Pour Babak Masoomian Mohammad Zarei Kaveh Fadakar Mojtaba Arjmand Fereshteh Tayebi Leila Ekradi Hamid Abrishami Moghaddam Tahereh Mahmoudi Reihaneh Daneshmand Hooshang Faghihi
author_facet	Ali Torkashvand Hamid Riazi-Esfahani Fariba Ghassemi Elias Khalili Pour Babak Masoomian Mohammad Zarei Kaveh Fadakar Mojtaba Arjmand Fereshteh Tayebi Leila Ekradi Hamid Abrishami Moghaddam Tahereh Mahmoudi Reihaneh Daneshmand Hooshang Faghihi
author_sort	Ali Torkashvand
title	Evaluation of radiation maculopathy after treatment of choroidal melanoma with ruthenium-106 using optical coherence tomography angiography
title_short	Evaluation of radiation maculopathy after treatment of choroidal melanoma with ruthenium-106 using optical coherence tomography angiography
title_full	Evaluation of radiation maculopathy after treatment of choroidal melanoma with ruthenium-106 using optical coherence tomography angiography
title_fullStr	Evaluation of radiation maculopathy after treatment of choroidal melanoma with ruthenium-106 using optical coherence tomography angiography
title_full_unstemmed	Evaluation of radiation maculopathy after treatment of choroidal melanoma with ruthenium-106 using optical coherence tomography angiography
title_sort	evaluation of radiation maculopathy after treatment of choroidal melanoma with ruthenium-106 using optical coherence tomography angiography
publisher	BMC
publishDate	2021
url	https://doaj.org/article/83c7accdf7bb4de8a281d42ff98ed5bc
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Evaluation of radiation maculopathy after treatment of choroidal melanoma with ruthenium-106 using optical coherence tomography angiography

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