P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim

Erythropoietin (EPO) stimulates erythropoiesis and is commonly used to treat anemia. Here Hu et al. find that P38α/JNK signaling restrains erythropoiesis independently of EPO by regulating epigenetic silencing of the proapoptotic protein Bim, and thus identify putative targets for the treatment of a...

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Autores principales:	Ping Hu, Angel R. Nebreda, Helmut Hanenberg, Garrett H. Kinnebrew, Mircea Ivan, Mervin C. Yoder, Marie-Dominique Filippi, Hal E. Broxmeyer, Reuben Kapur
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/83c7d281d7c544558201dc263cf809c2
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spelling	oai:doaj.org-article:83c7d281d7c544558201dc263cf809c22021-12-02T14:39:21ZP38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim10.1038/s41467-018-05955-22041-1723https://doaj.org/article/83c7d281d7c544558201dc263cf809c22018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05955-2https://doaj.org/toc/2041-1723Erythropoietin (EPO) stimulates erythropoiesis and is commonly used to treat anemia. Here Hu et al. find that P38α/JNK signaling restrains erythropoiesis independently of EPO by regulating epigenetic silencing of the proapoptotic protein Bim, and thus identify putative targets for the treatment of anemic disorders resistant to EPO.Ping HuAngel R. NebredaHelmut HanenbergGarrett H. KinnebrewMircea IvanMervin C. YoderMarie-Dominique FilippiHal E. BroxmeyerReuben KapurNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ping Hu Angel R. Nebreda Helmut Hanenberg Garrett H. Kinnebrew Mircea Ivan Mervin C. Yoder Marie-Dominique Filippi Hal E. Broxmeyer Reuben Kapur P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim
description	Erythropoietin (EPO) stimulates erythropoiesis and is commonly used to treat anemia. Here Hu et al. find that P38α/JNK signaling restrains erythropoiesis independently of EPO by regulating epigenetic silencing of the proapoptotic protein Bim, and thus identify putative targets for the treatment of anemic disorders resistant to EPO.
format	article
author	Ping Hu Angel R. Nebreda Helmut Hanenberg Garrett H. Kinnebrew Mircea Ivan Mervin C. Yoder Marie-Dominique Filippi Hal E. Broxmeyer Reuben Kapur
author_facet	Ping Hu Angel R. Nebreda Helmut Hanenberg Garrett H. Kinnebrew Mircea Ivan Mervin C. Yoder Marie-Dominique Filippi Hal E. Broxmeyer Reuben Kapur
author_sort	Ping Hu
title	P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim
title_short	P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim
title_full	P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim
title_fullStr	P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim
title_full_unstemmed	P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim
title_sort	p38α/jnk signaling restrains erythropoiesis by suppressing ezh2-mediated epigenetic silencing of bim
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/83c7d281d7c544558201dc263cf809c2
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P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim

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