CD8+ T lymphocyte is a main source of interferon-gamma production in Takayasu’s arteritis

Abstract Interferon-gamma (IFN-γ) is a cytokine involved in the pathogenesis of Takayasu’s arteritis (TAK). However, the source of IFN-γ in TAK patients is not fully clear. We aimed to investigate the source of IFN-γ in TAK. 60 TAK patients and 35 health controls were enrolled. The lymphocyte subset...

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Autores principales:	Yan-Long Ren, Tao-Tao Li, Wei Cui, Li-Min Zhao, Na Gao, Hua Liao, Jiang-Hui Zhang, Jun-Ming Zhu, Zhi-Yu Qiao, Shi-Chao Guo, Li-Li Pan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/83c8575454c34d4db7b552f7e80e11e4
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spelling	oai:doaj.org-article:83c8575454c34d4db7b552f7e80e11e42021-12-02T19:02:35ZCD8+ T lymphocyte is a main source of interferon-gamma production in Takayasu’s arteritis10.1038/s41598-021-96632-w2045-2322https://doaj.org/article/83c8575454c34d4db7b552f7e80e11e42021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96632-whttps://doaj.org/toc/2045-2322Abstract Interferon-gamma (IFN-γ) is a cytokine involved in the pathogenesis of Takayasu’s arteritis (TAK). However, the source of IFN-γ in TAK patients is not fully clear. We aimed to investigate the source of IFN-γ in TAK. 60 TAK patients and 35 health controls were enrolled. The lymphocyte subsets of peripheral blood were detected by flow cytometry, cytokines were detected by Bio-plex. The correlation among lymphocyte subsets, cytokines and disease activity indexes was analyzed by person correlation. The level of serum IFN-γ in TAK patients was significantly increased (P < 0.05). The percentage of CD3+IFN-γ+ cells in peripheral blood CD3+ cells was significantly higher in TAK patients than that of healthy control group (P = 0.002). A higher proportion of CD3+CD8+IFN-γ+ cells/CD3+IFN-γ+ cells (40.23 ± 11.98% vs 35.12 ± 11.51%, P = 0.049), and a significantly lower CD3+CD4+IFN-γ+/ CD3+CD8+IFN-γ+ ratio (1.34 ± 0.62% vs 1.80 ± 1.33%, P = 0.027) were showed in the TAK group than that of control group. The CD3+CD8+IFN-γ+/CD3+IFN-γ+ ratio was positively correlated with CD3+IFN-γ+cells/ CD3+cells ratio (r = 0.430, P = 0.001), serum IFN-γ level (r = 0.318, P = 0.040) and IL-17 level (r = 0.326, P = 0.031). It was negatively correlated with CD3+CD4+IFN-γ+/CD3+IFN-γ+ ratio (r = − 0.845, P < 0.001). IFN-γ secreted by CD3+CD8 + T cells is an important source of serum IFN-γ in TAK patients.Yan-Long RenTao-Tao LiWei CuiLi-Min ZhaoNa GaoHua LiaoJiang-Hui ZhangJun-Ming ZhuZhi-Yu QiaoShi-Chao GuoLi-Li PanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yan-Long Ren Tao-Tao Li Wei Cui Li-Min Zhao Na Gao Hua Liao Jiang-Hui Zhang Jun-Ming Zhu Zhi-Yu Qiao Shi-Chao Guo Li-Li Pan CD8+ T lymphocyte is a main source of interferon-gamma production in Takayasu’s arteritis
description	Abstract Interferon-gamma (IFN-γ) is a cytokine involved in the pathogenesis of Takayasu’s arteritis (TAK). However, the source of IFN-γ in TAK patients is not fully clear. We aimed to investigate the source of IFN-γ in TAK. 60 TAK patients and 35 health controls were enrolled. The lymphocyte subsets of peripheral blood were detected by flow cytometry, cytokines were detected by Bio-plex. The correlation among lymphocyte subsets, cytokines and disease activity indexes was analyzed by person correlation. The level of serum IFN-γ in TAK patients was significantly increased (P < 0.05). The percentage of CD3+IFN-γ+ cells in peripheral blood CD3+ cells was significantly higher in TAK patients than that of healthy control group (P = 0.002). A higher proportion of CD3+CD8+IFN-γ+ cells/CD3+IFN-γ+ cells (40.23 ± 11.98% vs 35.12 ± 11.51%, P = 0.049), and a significantly lower CD3+CD4+IFN-γ+/ CD3+CD8+IFN-γ+ ratio (1.34 ± 0.62% vs 1.80 ± 1.33%, P = 0.027) were showed in the TAK group than that of control group. The CD3+CD8+IFN-γ+/CD3+IFN-γ+ ratio was positively correlated with CD3+IFN-γ+cells/ CD3+cells ratio (r = 0.430, P = 0.001), serum IFN-γ level (r = 0.318, P = 0.040) and IL-17 level (r = 0.326, P = 0.031). It was negatively correlated with CD3+CD4+IFN-γ+/CD3+IFN-γ+ ratio (r = − 0.845, P < 0.001). IFN-γ secreted by CD3+CD8 + T cells is an important source of serum IFN-γ in TAK patients.
format	article
author	Yan-Long Ren Tao-Tao Li Wei Cui Li-Min Zhao Na Gao Hua Liao Jiang-Hui Zhang Jun-Ming Zhu Zhi-Yu Qiao Shi-Chao Guo Li-Li Pan
author_facet	Yan-Long Ren Tao-Tao Li Wei Cui Li-Min Zhao Na Gao Hua Liao Jiang-Hui Zhang Jun-Ming Zhu Zhi-Yu Qiao Shi-Chao Guo Li-Li Pan
author_sort	Yan-Long Ren
title	CD8+ T lymphocyte is a main source of interferon-gamma production in Takayasu’s arteritis
title_short	CD8+ T lymphocyte is a main source of interferon-gamma production in Takayasu’s arteritis
title_full	CD8+ T lymphocyte is a main source of interferon-gamma production in Takayasu’s arteritis
title_fullStr	CD8+ T lymphocyte is a main source of interferon-gamma production in Takayasu’s arteritis
title_full_unstemmed	CD8+ T lymphocyte is a main source of interferon-gamma production in Takayasu’s arteritis
title_sort	cd8+ t lymphocyte is a main source of interferon-gamma production in takayasu’s arteritis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/83c8575454c34d4db7b552f7e80e11e4
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CD8+ T lymphocyte is a main source of interferon-gamma production in Takayasu’s arteritis

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